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논문KCI 등재

저주파 반복적 경두개자기자극술 후 신경활성도의 변화

Changes in Neuronal Activity after Low Frequency Repetitive Transcranial Magnetic Stimulation

최경규|이향운|이민아|조현지|박기덕|김희진
대한신경과학회 (Korean Neurological Association)|2005.10|대한신경과학회지 (Journal of the Korean Neurological Association)|제23권 제5호|pp. 627-634

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참고문헌

주제분류신경과학

초록

Abstract

Backgrounds: A one Hz repetitive transcranial magnetic stimulation (rTMS) on the motor cortex is known to decrease motor cortical excitability locally, but the effects on distant areas or at different time points remain unclear. We investigated the spatiotemporal changes in cortical neuronal activity induced by local suprathreshold 1 Hz rTMS. Methods: Fourteen healthy subjects underwent daily rTMS for 5 consecutive days (1 Hz, 110% of resting motor threshold, 1800 stimuli) over the right temporal cortex (T4 of 10-20 international EEG system). EEG signals were collected at 19 electrodes baseline, before and after each rTMS session, and 2 weeks after the last rTMS session. Band powers of 2-4, 4-8, 8-13, 13-20, 20-40 Hz were calculated. Cross correlation (CC), mutual information (MI), and correlation dimension (D2), the maximum Lyapunov exponent (Lmax) were tested to investigate changes of EEG dynamics of synchronization and complexity. Wilcoxin signed ranks test was used for statistical analysis. Results: One Hz rTMS immediately caused a significant increase in alpha, gamma, theta band powers and the Lmax (p<0.0001 to 0.041, p<0.0001 to 0.038, respectively) in ipsilateral and contralateral hemispheres after daily rTMS. CC and MI decreased after daily rTMS sessions at the right frontocentrotemporal and left frontotemporal areas (p<0.001 to 0.041). Conclusions: These findings suggest that focal 1 Hz rTMS can induce a short-term increase in the neuronal complexity and de-synchronization of local neuronal networks at stimulated and distant cortical areas. These findings raise a possibility of therapeutic applications of low frequency rTMS in patients with an abnormally excitable brain cortex such as epilepsy or movement disorders.

참고문헌 (36)

  1. "Stimulation of cerebral cortex in the intact human subject", 285, pp.227~ (1980)
  2. "Flip side of synaptic plasticity:long-term depression mechanisms in the hippocampus", 4, pp.127~135 (1994)
  3. "Synaptic plasticity.Mucking up movements", 372, pp.218~219 (1994)
  4. "Decreased corticospinal excitability after after subthreshold 1 Hz rTMS over lateral premotor cortex", 57, pp.449~455 (2001)
  5. "Functional connectivity of human premotor and motor cortex explored with repetitive transcranial magnetic stimulation", 22, pp.554~561 (2002)
  6. "Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation", 48, pp.1398~1403 (1997)
  7. "Interhemispheric inhibition in patients with multiple sclerosis", 109, pp.230~237 (1998)
  8. "Response to rapid-rate transcranial magnetic stimulation of the human motor cortex", 117, pp.847~858 (1994)
  9. "An introduction to bispectral analysis for the electroencephalogram", 10, pp.329~404 (1994)
  10. "Usefulness of non-linear EEG analysis", 97, pp.13~19 (1998)
  11. "Dynamics of brain electrical activity", 2, pp.99~118 (1989)
  12. "Nonlinear EEG analysis and its potential role in epileptology", 41 suppl 3 (2000)
  13. "Transcranial magnetic stimulation in neurology", 2, pp.145~156 (2003)
  14. "The cortical silent period:intrinsic variability and relation to the waveform of the transcranial magnetic stimulation pulse", 115, pp.1076~1082 (2004)
  15. "Advances in quantitative electroencephalogram analysis methods", 6, pp.453~495 (2004)
  16. "Nonlinear dynamic characteristics of electroencephalography in a high-dose pilocarpine-induced status epilepticus model", 54, pp.179~188 (2003)
  17. "Nonlinear analysis of EEG in various mental states of normal person", 18, pp.581~588 (2000)
  18. "Use and safety of a new repetitive transcranial magnetic stimulator", 101, pp.412~417 (1996)
  19. "Are the after-effects of low-frequency rTMS on motor cortex excitability due to changes in the efficacy of cortical synapses", pp.2138~2145
  20. "Effects of low frequency and low intensity repetitive paired pulse stimulation of the primary motor cortex", 115, pp.1259~1263 (2004)
  21. "Modeling of magnetic field stimulation of bent neurons", 41, pp.1092~1095 (1994)
  22. "Transcranial magnetic stimulation:a revolution in clinical neurophysiology", 19, pp.253~254 (2002)
  23. "NMDA-receptor-dependent synaptic plasticity:multiple forms and mechanisms", 16, pp.521~527 (1993)
  24. "Transcranial magnetic stimulation induces alterations in brain monoamines", 104, pp.191~197 (1997)
  25. "Chronic repetitive transcranial magnetic stimulation alters beta-adrenergic and 5-HT2 receptor characteristics in rat brain", pp.78~83
  26. "Changes in 5-HT1A and NMDA binding sites by a single rapid transcranial magnetic stimulation procedure in rats", 826, pp.309~312 (1999)
  27. "Simulation of EEG:dynamic changes in synaptic efficacy,cerebral rhythms,and dissipative and generative activity in cortex", 81, pp.131~147 (1999)
  28. "Nonlinear analysis of EEG after repetitive transcranial magnetic stimulation", 19, pp.16~23 (2002)
  29. "Spatio-temporal dynamics of the primary epileptogenic area in temporal lobe epilepsy characterized by neuronal complexity loss", 95, pp.108~117 (1995)
  30. "Comparison of human ictal,interictal and normal non-linear component analyses", 111, pp.1282~1292 (2000)
  31. "Neuroactive amino acids in focally epileptic human brain:a review", 24, pp.1387~1395 (1999)
  32. "Glutamate receptors and transporters in genetic and acquired models of epilepsy", 36, pp.189~204 (1999)
  33. "Transcranial magnetic stimulation in epileptic patients:usefulness and safety", 40, pp.1132~1133 (1990)
  34. "Transcranial magnetic stimulation:its current role in epilepsy research", 30, pp.11~30 (1998)
  35. "Low-frequency repetitive transcranial magnetic stimulation improves intractable epilepsy", 353, pp.2209~ (1999)
  36. "Transcranial magnetic stimulation for the treatment of seizures:a controlled study", 59, pp.560~562 (2002)

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