Effects of Particulate Matter on Healthy Skin: A Comparative Study between High- and Low-Particulate Matter Periods
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background: The influence of airborne particulate matter (PM) on skin has primarily been studied in patients with skin diseases such as atopic dermatitis. Recently, the effect of PM on healthy human skin has gained attention. Objective: To evaluate the relationship between PM concentration and objective skin changes in healthy subjects. Methods: This prospective study enrolled 25 healthy volunteers without any skin disease. Data regarding daily meteorological parameters and air pollution were collected during a high-PM period and a low-PM period for 14 days. Environmental and lifestyle factors that might influence skin conditions of subjects were also collected during the study period. Biophysical parameters of the skin such as transepidermal water loss (TEWL), hydration, erythema index, and melanin index were measured. Pores, wrinkles, sebum, and skin tone were evaluated using a facial analysis system. Results: Mean TEWL value during the high-PM period was significantly higher than that during the low-PM period (10.16 g/m2/h vs. 5.99 g/m2/h; p=0.0005). Mean erythema index was significantly higher in the high- PM period than that in the low-PM period (4.3 vs. 3.42; p=0.038). For facial analysis system indices, uniformity of skin tone was higher in the low-PM period than that in the high-PM period (p＜0.0001). In addition, with increasing PM10 and PM2.5, TEWL also showed increase when other environmental components were constant (regression coefficient [RC]=0.1529, p＜0.0001 for PM10; RC=0.2055, p=0.0153 for PM2.5). Conclusion: Increased PM concentrations may contribute to disturbed barrier function, increased facial erythema, and uneven skin tone even in healthy human skin.
Abstract
Background: The influence of airborne particulate matter (PM) on skin has primarily been studied in patients with skin diseases such as atopic dermatitis. Recently, the effect of PM on healthy human skin has gained attention. Objective: To evaluate the relationship between PM concentration and objective skin changes in healthy subjects. Methods: This prospective study enrolled 25 healthy volunteers without any skin disease. Data regarding daily meteorological parameters and air pollution were collected during a high-PM period and a low-PM period for 14 days. Environmental and lifestyle factors that might influence skin conditions of subjects were also collected during the study period. Biophysical parameters of the skin such as transepidermal water loss (TEWL), hydration, erythema index, and melanin index were measured. Pores, wrinkles, sebum, and skin tone were evaluated using a facial analysis system. Results: Mean TEWL value during the high-PM period was significantly higher than that during the low-PM period (10.16 g/m2/h vs. 5.99 g/m2/h; p=0.0005). Mean erythema index was significantly higher in the high- PM period than that in the low-PM period (4.3 vs. 3.42; p=0.038). For facial analysis system indices, uniformity of skin tone was higher in the low-PM period than that in the high-PM period (p＜0.0001). In addition, with increasing PM10 and PM2.5, TEWL also showed increase when other environmental components were constant (regression coefficient [RC]=0.1529, p＜0.0001 for PM10; RC=0.2055, p=0.0153 for PM2.5). Conclusion: Increased PM concentrations may contribute to disturbed barrier function, increased facial erythema, and uneven skin tone even in healthy human skin.
참고문헌 (27)
- Schwarze PE, "Particulate matter properties and health effects : consistency of epidemiological and toxicological studies", Hum Exp Toxicol, 25, pp.559~579 (2006)
- 노주환, "Short-term Effects of Ambient Air Pollution on Emergency Department Visits for Asthma: An Assessment of Effect Modification by Prior Allergic Disease History", 예방의학회지, 49(5), pp.329~341 (2016), 대한예방의학회
- Ngoc LTN, "Systematic review and meta-analysis of human skin diseases due to particulate matter", Int J Environ Res Public Health, 14, pp.1458~ (2017)
- Pope CA 3rd, "Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution", JAMA, 287, pp.1132~1141 (2002)
- Dominici F, "Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases", JAMA, 295, pp.1127~1134 (2006)
- Mustafic H, "Main air pollutants and myocardial infarction : a systematic review and meta-analysis", JAMA, 307, pp.713~721 (2012)
- Peng F, "Exposure to fine particulate matter associated with senile lentigo in Chinese women : a cross-sectional study", J Eur Acad Dermatol Venereol, 31, pp.355~360 (2017)
- Wyzga RE, "Long-term particulate matter exposure : attributing health effects to individual PM components", J Air Waste Manag Assoc, 65, pp.523~543 (2015)
- Vierkötter A, "Airborne particle exposure and extrinsic skin aging", J Invest Dermatol, 130, pp.2719~2726 (2010)
- Kim J, "Symptoms of atopic dermatitis are influenced by outdoor air pollution", J Allergy Clin Immunol, 132, pp.495~498 (2013)
- Watanabe M, "Association of short-term exposure to ambient fine particulate matter with skin symptoms in schoolchildren : a panel study in a rural area of Western Japan", Int J Environ Res Public Health, 14, pp.299~ (2017)
- Oh I, "Association between particulate matter concentration and symptoms of atopic dermatitis in children living in an industrial urban area of South Korea", Environ Res, 160, pp.462~468 (2018)
- Otani S, "The relationship between skin symptoms and allergic reactions to Asian dust", Int J Environ Res Public Health, 9, pp.4606~4614 (2012)
- Park JH, "Effects of particulate matter on healthy human skin: a panel study using a smartphone application measuring daily skin condition", J Eur Acad Dermatol Venereol, 33, pp.1363~1368 (2019)
- Jin Q, "Spatio-temporal variations of PM2.5 emission in China from 2005 to 2014", Chemosphere, 183, pp.429~436 (2017)
- Choi SH, "Behavior of particulate matter during high concentration episodes in Seoul", Environ Sci Pollut Res Int, 21, pp.5972~5982 (2014)
- Piérard GE, "EEMCO guidance for the in vivo assessment of skin greasiness. The EEMCO Group", Skin Pharmacol Appl Skin Physiol, 13, pp.372~389 (2000)
- Rogiers V, "EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences", Skin Pharmacol Appl Skin Physiol, 14, pp.117~128 (2001)
- Kim YM, "The effects of particulate matter on atopic dermatitis symptoms are influenced by weather type: application of spatial synoptic classification (SSC)", Int J Hyg Environ Health, 221, pp.823~829 (2018)
- Kim KH, "Airborne iron across major urban centers in South Korea between 1991 and 2012", Sci Total Environ, 550, pp.309~320 (2016)
- Larese Filon F, "Nanoparticles skin absorption : new aspects for a safety profile evaluation", Regul Toxicol Pharmacol, 72, pp.310~322 (2015)
- Kim KE, "Air pollution and skin diseases:adverse effects of airborne particulate matter on various skin diseases", Life Sci, 152, pp.126~134 (2016)
- Araviiskaia E, "The impact of airborne pollution on skin", J Eur Acad Dermatol Venereol, 33, pp.1496~1505 (2019)
- Afaq F, "Aryl hydrocarbon receptor is an ozone sensor in human skin", J Invest Dermatol, 129, pp.2396~2403 (2009)
- Li A, "Associations between air pollution, climate factors and outpatient visits for eczema in West China Hospital, Chengdu, south-western China: a time series analysis", J Eur Acad Dermatol Venereol, 32, pp.486~494 (2018)
- Fuller CH, "Indoor and outdoor measurements of particle number concentration in near-highway homes", J Expo Sci Environ Epidemiol, 23, pp.506~512 (2013)
- Lee JY, "Indoor-to-outdoor particle concentration ratio model for human exposure analysis", Atmos Environ, 127, pp.100~106 (2016)