고산 등반 이후 발생한 인지기능장애
Cognitive Dysfunction Following High Mountain Climbing
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Few studies have investigated cognitive impairment associated with globus pallidal lesion after acute mountain sickness (AMS). A 54-year-old mountaineer presented with a slowed response, social withdrawal, and apathy after exposure to high altitude. Neuropsychological evaluation revealed impairment in memory and frontal function. MRI revealed bilateral globus pallidal lesions and SPECT revealed decreased blood flow in the left temporal cortex. Symptoms and imaging findings were still impaired after 3 years. We speculate that globus pallidal lesions can cause cognitive dysfunction in AMS.
Abstract
Few studies have investigated cognitive impairment associated with globus pallidal lesion after acute mountain sickness (AMS). A 54-year-old mountaineer presented with a slowed response, social withdrawal, and apathy after exposure to high altitude. Neuropsychological evaluation revealed impairment in memory and frontal function. MRI revealed bilateral globus pallidal lesions and SPECT revealed decreased blood flow in the left temporal cortex. Symptoms and imaging findings were still impaired after 3 years. We speculate that globus pallidal lesions can cause cognitive dysfunction in AMS.
참고문헌 (10)
- Virues-Ortega J, "Neuropsychological functioning associated with high-altitude exposure", Neuropsycho Rev, 14, pp.197~221 (2004)
- Swaminath PV, "Parkinsonism and personality changes following an acute hypoxic insult during mountaineering", Mov Disord, 21, pp.1296~1297 (2006)
- Roach RC, "The Lake Louise acute mountain sickness scoring system. In Hypoxia and molecular medicine", pp.272~274 (1993), Burlington, VT: Queen City Printers
- Wilson MH, "The cerebral effects of ascent to high altitudes", Lancet Neurol, 8, pp.175~191 (2009)
- Shukitt-Hale B, "Hypobaric hypoxia impairs spatial memory in an elevation-dependent fashion", Behav Neural Biol, 62, pp.244~252 (1994)
- Hackett PH, "High-altitude cerebral edema evaluated with magnetic resonance imaging: clinical correlation and pathophysiology", JAMA, 280, pp.1920~1925 (1998)
- JeeHyangJeong, "Globus Pallidus Lesions Associated with High Mountain Climbing", Journal of Korean Medical Science, 17(6), pp.861~863 (2002), 대한의학회
- Hochachka PW, "Sherpa brain glucose metabolism and defense adaptations against chronic hypoxia", J Appl Physiol, 81, pp.1355~1361 (1996)
- Townes B, "Human cerebral function at extreme altitude. In High altitude and Man", pp.31~36 (1984), Bethesda American Physiological Society: Bethesda
- Regard M, "Persistent cognitive impairment in climbers after repeated exposure to extreme altitude", Neurol, 39, pp.210~213 (1989)