엽산과 시아노코발라민 투여로 회복된 경막내 화학요법과 연관된 척수병증
Intrathecal Chemotherapy Related Myelopathy Improved with Folate and Cyanocobalamin
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Intrathecal chemotherapy with methotrexate and cytarabine arabinoside is used for the treatment and prophylaxis of malignancies, but can induce myelopathy. We report the case of a 50-year-old woman with stomach cancer who developed myelopathy after administration of intrathecal cytarabine arabinoside and methotrexate. The patient’s neurologic status improved rapidly after the administration of folinate (15 mg) four times daily and cyanocobalamin (100 μg) once daily. The folate metabolites may be effective in the management of intrathecal-chemotherapy-induced myelopathy.
Abstract
Intrathecal chemotherapy with methotrexate and cytarabine arabinoside is used for the treatment and prophylaxis of malignancies, but can induce myelopathy. We report the case of a 50-year-old woman with stomach cancer who developed myelopathy after administration of intrathecal cytarabine arabinoside and methotrexate. The patient’s neurologic status improved rapidly after the administration of folinate (15 mg) four times daily and cyanocobalamin (100 μg) once daily. The folate metabolites may be effective in the management of intrathecal-chemotherapy-induced myelopathy.
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