Diagnostic Pearls of Vulvar Epidermolytic Acanthoma: Case Report
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Epidermolytic acanthomas (EA) are uncommon benign tumors clinically presenting as single to multiple papules. Histologically, EA display hyperkeratosis, hypergranulosis, acan- thosis, and epidermal degeneration—also known as epidermolytic hyperkeratosis (EH). EA may be misdiagnosed as condyloma both clinically and histopathologically when located on the genitalia. Thus, this diagnosis carries a significant psychological burden and must remain in the differential when initially considering genital warts. We utilize the case of a 62-year old female referred to dermatology for a 5-year history of multiple pruritic and hy- popigmented vulvar papules—misdiagnosed as genital warts—to highlight the impact of differentiating EA from genital warts. This patient was initially misdiagnosed with common genital warts at her gynecologist’s office and treated unsuccessfully for years. A shave biopsy was performed and histology revealed EH, consistent with EA.
Abstract
Epidermolytic acanthomas (EA) are uncommon benign tumors clinically presenting as single to multiple papules. Histologically, EA display hyperkeratosis, hypergranulosis, acan- thosis, and epidermal degeneration—also known as epidermolytic hyperkeratosis (EH). EA may be misdiagnosed as condyloma both clinically and histopathologically when located on the genitalia. Thus, this diagnosis carries a significant psychological burden and must remain in the differential when initially considering genital warts. We utilize the case of a 62-year old female referred to dermatology for a 5-year history of multiple pruritic and hy- popigmented vulvar papules—misdiagnosed as genital warts—to highlight the impact of differentiating EA from genital warts. This patient was initially misdiagnosed with common genital warts at her gynecologist’s office and treated unsuccessfully for years. A shave biopsy was performed and histology revealed EH, consistent with EA.
참고문헌 (20)
- Fletcher JW, "Presentation of epidermolytic acanthomas as multiple tan papules on the vulva", Proc(Bayl Univ Med Cent), 29, pp.198~199 (2016)
- Shapiro L, "Isolated epidermolytic acanthoma. A solitary tumor showing granular degeneration", Arch Dermatol, 101, pp.220~223 (1970)
- Niizuma K, "Isolated epidermolytic acanthoma. A histological study", Dermatologica, 159, pp.30~36 (1979)
- Roy SF, "Solitary and multiple epidermolytic acanthoma : a demographic and clinical study of 131cases", J Cutan Pathol, 46, pp.305~309 (2019)
- Lee TJ, "Multiple epidermolytic acanthomas mimicking condyloma : a retrospective study of 8 cases", Int J Dermatol, 57, pp.28~33 (2018)
- Egozi-Reinman E, "Epidermolytic acanthoma of the genitalia does not show mutations in KRT1 or KRT10", Am J Dermatopathol, 38, pp.164~165 (2016)
- Irwin S, "Multiple epidermolytic acanthomas : rare vulval lesions which may be mistaken for viral warts", Int J Gynecol Pathol, 39, pp.93~96 (2020)
- Hijazi MM, "Multiple localized epidermolytic acanthomas of the vulva associated with vulvar pruritus : a case report", Am J Dermatopathol, 37, pp.e49~ (2015)
- Swann MH, "Localized epidermolytic hyperkeratosis of the female external genitalia", J Cutan Pathol, 30, pp.379~381 (2003)
- High WA, "Localized epidermolytic hyperkeratosis of the female genitalia : a case report and review of an underappreciated disorder of women", MedGenMed, 7, pp.33~ (2005)
- Thomas M, "Linear epidermolytic acanthoma of vulva : an unusual presentation", Indian J Dermatol Venereol Leprol, 76, pp.49~51 (2010)
- Moulonguet I, "Multiple epidermolytic acanthomas of the genitalia", Ann Dermatol Venereol, 144, pp.295~300 (2017)
- Quinn TR, "Epidermolytic hyperkeratosis in the lower female genital tract : an uncommon simulant of mucocutaneous papillomavirus infection--a report of two cases", Int J Gynecol Pathol, 16, pp.163~168 (1997)
- Russell P, "Localised epidermolytic hyperkeratosis of the vulva : a case of mistaken identity", Pathology, 42, pp.483~485 (2010)
- Dupont A, "a case report", Dermatopathology(Basel), 6, pp.23~27 (2019)
- Chung M, "Verrucous papules on the scrotum", JAAD Case Rep, 6, pp.13~15 (2019)
- Ho J, "Mimickers of classic acantholytic diseases", J Dermatol, 44, pp.232~242 (2017)
- Bogale SR, "Epidermolytic acanthoma of the scrotum : a rare mimicker of condyloma acuminatum", Dermatol Online J, 17, pp.6~ (2011)
- Heller DS, "Benign papular lesions of the vulva", J Low Genit Tract Dis, 16, pp.296~305 (2012)
- Kukreja T, "Multiple epidermolytic acanthomas must not be confused with genital human papillomavirus infection", Acta Derm Venereol, 89, pp.169~171 (2009)