Fractional Photothermolysis for Treatment of a Residual Discoid Lupus Erythematosus Lesion: A Case Report
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Cutaneous discoid lupus erythematosus (CDLE) is a chronic inflammatory skin disease often resulting in permanent scarring of the affected area. Fractional photothermolysis (FP) is a well-known inducer of tissue regeneration by wounding the skin in a fractional pattern, hence inducing a well defined, wound healing response. It has been used clinically to treat atrophic as well as hypertrophic scars and also fibrotic diseases like morphea since more than a decade. We report a case of a young female patient treated with three sessions of ablative FP for stable atrophic scars due to CDLE affection of the upper left and right cheeks. After the last treatment, no side effects were observed. At the 13-month follow-up visit, the treated atrophic scars showed satisfying improvement for the patient. Skin texture, relief, color, and overall cosmetic appearance were all rated as improved by three independent dermatologists. No signs of unwanted side effects were observed at any time point. This case report should be followed up with a larger case series or ideally a prospective randomized clinical trial to better establish FP as a safe and effective tool to treat reminiscent scars after CDLE.
Abstract
Cutaneous discoid lupus erythematosus (CDLE) is a chronic inflammatory skin disease often resulting in permanent scarring of the affected area. Fractional photothermolysis (FP) is a well-known inducer of tissue regeneration by wounding the skin in a fractional pattern, hence inducing a well defined, wound healing response. It has been used clinically to treat atrophic as well as hypertrophic scars and also fibrotic diseases like morphea since more than a decade. We report a case of a young female patient treated with three sessions of ablative FP for stable atrophic scars due to CDLE affection of the upper left and right cheeks. After the last treatment, no side effects were observed. At the 13-month follow-up visit, the treated atrophic scars showed satisfying improvement for the patient. Skin texture, relief, color, and overall cosmetic appearance were all rated as improved by three independent dermatologists. No signs of unwanted side effects were observed at any time point. This case report should be followed up with a larger case series or ideally a prospective randomized clinical trial to better establish FP as a safe and effective tool to treat reminiscent scars after CDLE.
참고문헌 (18)
- Stannard JN, "Cutaneous lupus erythematosus : updates on pathogenesis and associations with systemic lupus", Curr Opin Rheumatol, 28, pp.453~459 (2016)
- Tebbe B, "Epidemiology and socioeconomic impact of skin disease in lupus erythematosus", Lupus, 6, pp.96~104 (1997)
- Andersen LK, "Prevalence of skin and skin-related diseases in the rochester epidemiology project and a comparison with other published prevalence studies", Dermatology, 232, pp.344~352 (2016)
- Kuhn A, "Advances in the treatment of cutaneous lupus erythematosus", Lupus, 25, pp.830~837 (2016)
- Manstein D, "Fractional photothermolysis : a new concept for cutaneous remodeling using microscopic patterns of thermal injury", Lasers Surg Med, 34, pp.426~438 (2004)
- Laubach HJ, "Skin responses to fractional photothermolysis", Lasers Surg Med, 38, pp.142~149 (2006)
- Kineston D, "Use of a fractional ablative 10. 6-μm carbon dioxide laser in the treatment of a morphea-related contracture", Arch Dermatol, 147, pp.1148~1150 (2011)
- Brauer JA, "Laser therapy in the treatment of connective tissue diseases : a review", Dermatol Surg, 40, pp.1~13 (2014)
- Bolognia J, "Dermatology", pp.2776~ (2012), Elsevier
- WolffK, "Fitzpatrick’s dermatology in general medicine", pp.2748~ (2007), McGraw-Hill Medical
- Brás S, "Treatment of lupus erythematosus of the eyelids with pulsed dye laser", Lasers Med Sci, 33, pp.215~219 (2018)
- Henderson DL, "Laser treatment of discoid lupus(case report)", Lasers Surg Med, 6, pp.12~15 (1986)
- Walker SL, "Carbon dioxide laser resurfacing of facial scarring secondary to chronic discoid lupus erythematosus", Br J Dermatol, 143, pp.1101~1102 (2000)
- Verma SM, "The impact of skin damage due to cutaneous lupus on quality of life", Br J Dermatol, 170, pp.315~321 (2014)
- Alster TS, "The use of fractional laser photothermolysis for the treatment of atrophic scars", Dermatol Surg, 33, pp.295~299 (2007)
- Hasegawa T, "Clinical trial of a laser device called fractional photothermolysis system for acne scars", J Dermatol, 33, pp.623~627 (2006)
- Lehmann P, "Photodermatoses : diagnosis and treatment", Dtsch Arztebl Int, 108, pp.135~141 (2011)
- García-Montero P, "Usefulness of pulsed dye laser in cutaneous lupus erythematosus", Actas Dermosifiliogr(Engl Ed), 110, pp.398~399 (2019)