Impact of Pediatric Alopecia Areata on Quality of Life of Patients and Their Family Members: A Nationwide Multicenter Questionnaire Study
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Background: Pediatric alopecia areata (AA) can affect the quality of life (QoL) of patients and their family members. Research on the QoL and burden on family members in pediat- ric AA is limited. Objective: This nationwide multicenter questionnaire study described the QoL and burden of the family members of patients with pediatric AA. Methods: This nationwide multicenter questionnaire study enrolled AA patients between the ages of 5 and 18 years from March 1, 2017 to February 28, 2018. Enrolled patients and their parents completed the modified Children’s Dermatology Life Quality Index (CDLQI) and the modified Dermatitis Family Impact (mDFI). The disease severity was measured using the Severity of Alopecia Tool (SALT) survey scores. Results: A total of 268 patients with AA from 22 hospitals participated in this study. Our study found that the efficacy and satisfaction of previous treatments of AA decreased as the severity of the disease increased. The use of home-based therapies and traditional medicines increased with the increasing severity of the disease, but the efficacy felt by patients was limited. CDLQI and mDFI scores were higher in patients with extensive AA than those with mild to moderate AA. The economic and time burden of the family mem- bers also increased as the severity of the disease increased. Conclusion: The severity of the AA is indirectly proportional to the QoL of patients and their family members and directly proportional to the burden. Physicians need to under- stand these characteristics of pediatric AA and provide appropriate intervention to pa- tients and their family members.
Abstract
Background: Pediatric alopecia areata (AA) can affect the quality of life (QoL) of patients and their family members. Research on the QoL and burden on family members in pediat- ric AA is limited. Objective: This nationwide multicenter questionnaire study described the QoL and burden of the family members of patients with pediatric AA. Methods: This nationwide multicenter questionnaire study enrolled AA patients between the ages of 5 and 18 years from March 1, 2017 to February 28, 2018. Enrolled patients and their parents completed the modified Children’s Dermatology Life Quality Index (CDLQI) and the modified Dermatitis Family Impact (mDFI). The disease severity was measured using the Severity of Alopecia Tool (SALT) survey scores. Results: A total of 268 patients with AA from 22 hospitals participated in this study. Our study found that the efficacy and satisfaction of previous treatments of AA decreased as the severity of the disease increased. The use of home-based therapies and traditional medicines increased with the increasing severity of the disease, but the efficacy felt by patients was limited. CDLQI and mDFI scores were higher in patients with extensive AA than those with mild to moderate AA. The economic and time burden of the family mem- bers also increased as the severity of the disease increased. Conclusion: The severity of the AA is indirectly proportional to the QoL of patients and their family members and directly proportional to the burden. Physicians need to under- stand these characteristics of pediatric AA and provide appropriate intervention to pa- tients and their family members.
참고문헌 (23)
- Simakou T, "Alopecia areata : a multifactorial autoimmune condition", J Autoimmun, 98, pp.74~85 (2019)
- Olsen EA, "Alopecia areata investigational assessment guidelines : Part II. National alopecia areata foundation", J Am Acad Dermatol, 51, pp.440~447 (2004)
- Toussi A, "Psychosocial and psychiatric comorbidities and health-related quality of life in alopecia areata : a systematic review", J Am Acad Dermatol, 85, pp.162~175 (2021)
- 전명수, "Quality of Life with Alopecia Areata versus Androgenetic Alopecia Assessed Using Hair Specific Skindex-29", Annals of Dermatology, 30(3), pp.388~391 (2018), 대한피부과학회
- Putterman E, "Severity of disease and quality of life in parents of children with alopecia areata, totalis, and universalis : a prospective, cross-sectional study", J Am Acad Dermatol, 80, pp.1389~1394 (2019)
- Pustišek N, "Quality of life in families with children with atopic dermatitis", Pediatr Dermatol, 33, pp.28~32 (2016)
- Poachanukoon O, "Pediatric Asthma Quality of Life Questionnaire(PAQLQ) : validation among asthmatic children in Thailand", Pediatr Allergy Immunol, 17, pp.207~212 (2006)
- Lewis-Jones MS, "The Children’s Dermatology Life Quality Index(CDLQI) : initial validation and practical use", Br J Dermatol, 132, pp.942~949 (1995)
- Lawson V, "The family impact of childhood atopic dermatitis : the dermatitis family impact questionnaire", Br J Dermatol, 138, pp.107~113 (1998)
- Janković S, "Quality of life in patients with alopecia areata : a hospital-based cross-sectional study", J Eur Acad Dermatol Venereol, 30, pp.840~846 (2016)
- Olsen JR, "Quality of life impact of childhood skin conditions measured using the Children’s Dermatology Life Quality Index(CDLQI) : a meta-analysis", Br J Dermatol, 174, pp.853~861 (2016)
- Dodington SR, "The Dermatitis Family Impact questionnaire : a review of its measurement properties and clinical application", Br J Dermatol, 169, pp.31~46 (2013)
- 박창근, "유？소아기 아토피피부염이 환아의 삶의 질과 가족에 미치는 영향", 대한피부과학회지, 45(5), pp.429~438 (2007), 대한피부과학회
- Conic RZ, "Comorbidities in pediatric alopecia areata", J Eur Acad Dermatol Venereol, 34, pp.2898~2901 (2020)
- Paller A, "Major comorbidities of atopic dermatitis : beyond allergic disorders", Am J Clin Dermatol, 19, pp.821~838 (2018)
- Hoffmann R, "Topical immunotherapy in alopecia areata. What, how, and why?", Dermatol Clin, 14, pp.739~744 (1996)
- Auriemma M, "Cytokines and T cells in atopic dermatitis", Eur Cytokine Netw, 24, pp.37~44 (2013)
- 유혜린, "Factors Associated with Severity of Alopecia Areata", Annals of Dermatology, 29(5), pp.565~570 (2017), 대한피부과학회
- Ražnatović Ðurović M, "Impact of atopic dermatitis on the quality of life of children and their families", Ital J Dermatol Venerol, 156, pp.29~35 (2021)
- de Jager ME, "A crosssectional study using the Children’s Dermatology Life Quality Index(CDLQI)in childhood psoriasis : negative effect on quality of life and moderate correlation of CDLQI with severity scores", Br J Dermatol, 163, pp.1099~1101 (2010)
- Beattie PE, "An audit of the impact of a consultation with a paediatric dermatology team on quality of life in infants with atopic eczema and their families : further validation of the infants’ dermatitis quality of life index and dermatitis family impact score", Br J Dermatol, 155, pp.1249~1255 (2006)
- de Vere Hunt I, "A qualitative exploration of the experiences of adolescents with alopecia areata and their messages for healthcare professionals", Br J Dermatol, 184, pp.557~559 (2021)
- Li SJ, "Association of outof-pocket health care costs and financial burden for patients with alopecia areata", JAMA Dermatol, 155, pp.493~494 (2019)