Allergic Sensitization Pattern in the Korean Dermatologic Patients
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Background: Avoiding causative allergens is important for controlling the clinical courseof allergic diseases. Allergen sensitization is inf luenced by many factors including the envi-ronment and lifestyle. The socioeconomic development, climate, and lifestyle changes haveincreased the prevalence of allergic diseases worldwide. However, there is little informationabout changes in the trend of the common allergens over time. Objective: This study was aimed at identifying the trends of the common allergens in Koreaover a 10-year period based on the results of the multiple allergosorbent test chemilumines-cent assay (MAST-CLA). Methods: We retrospectively reviewed the medical records of 5,760 patients aged ≥18 yearswho visited the Dermatology Department at a tertiary hospital over a period of 10 years. Theserum total immunoglobulin (Ig) E and specific IgE levels to 41 allergens were determinedusing MAST-CLA, along with the clinical diagnosis, duration of illness, white blood cellcount and eosinophil percentage. Results: Dermatophagoides farinae, Dermatophagoides pteronyssinus , and house dust werethe most prevalent allergens during the 10 years period, but the percentage of higher classresponses has decreased in recent years. The number of patients sensitized to house dust(p<0.001), dogs (p =0.005), and cats (p<0.001) increased while that of patients sensitized tocockroaches (p<0.001) and storage mites (p<0.001) decreased over time. There were no sig-nificant changes in the total number of sensitizing allergens over time. Conclusion: The common allergens have changed over time. Based on the findings of thisstudy, physicians and patients should consider changing their strategies for disease preven-tion and management.
Abstract
Background: Avoiding causative allergens is important for controlling the clinical courseof allergic diseases. Allergen sensitization is inf luenced by many factors including the envi-ronment and lifestyle. The socioeconomic development, climate, and lifestyle changes haveincreased the prevalence of allergic diseases worldwide. However, there is little informationabout changes in the trend of the common allergens over time. Objective: This study was aimed at identifying the trends of the common allergens in Koreaover a 10-year period based on the results of the multiple allergosorbent test chemilumines-cent assay (MAST-CLA). Methods: We retrospectively reviewed the medical records of 5,760 patients aged ≥18 yearswho visited the Dermatology Department at a tertiary hospital over a period of 10 years. Theserum total immunoglobulin (Ig) E and specific IgE levels to 41 allergens were determinedusing MAST-CLA, along with the clinical diagnosis, duration of illness, white blood cellcount and eosinophil percentage. Results: Dermatophagoides farinae, Dermatophagoides pteronyssinus , and house dust werethe most prevalent allergens during the 10 years period, but the percentage of higher classresponses has decreased in recent years. The number of patients sensitized to house dust(p<0.001), dogs (p =0.005), and cats (p<0.001) increased while that of patients sensitized tocockroaches (p<0.001) and storage mites (p<0.001) decreased over time. There were no sig-nificant changes in the total number of sensitizing allergens over time. Conclusion: The common allergens have changed over time. Based on the findings of thisstudy, physicians and patients should consider changing their strategies for disease preven-tion and management.
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