정상 신기능 직장암 환자에서 Intravenous Tramadol 이회 투여 후 호흡곤란 발생 증례 보고
Respiratory Depression After the Second Dose of Intravenous Tramadol in a Rectal Cancer Patient with Normal Renal Function: A Clinical Case Report
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
We report an unusual case of respiratory depression and prolonged apnea after the second dose of 100-mg intravenous tramadol. Due to continuous pain at foley catheter keep site, intravenous tramadol was administered to the patient. Soon after the second dose of tramadol injection, the patient became apneic. The patient did not respond to verbal command and started exhibiting oxygen desaturation. The patient was quickly treated with 100% oxygen, and it took 4 hours for the spontaneous respiration to return to regular. This case report demonstrates that even two doses of tramadol administered intravenously may manifest as sudden and prolonged apnea. Respiratory depression with tramadol has been reported in patients with impaired renal functions and Cytochrome P(CYP) 2D6 gene duplication
Abstract
We report an unusual case of respiratory depression and prolonged apnea after the second dose of 100-mg intravenous tramadol. Due to continuous pain at foley catheter keep site, intravenous tramadol was administered to the patient. Soon after the second dose of tramadol injection, the patient became apneic. The patient did not respond to verbal command and started exhibiting oxygen desaturation. The patient was quickly treated with 100% oxygen, and it took 4 hours for the spontaneous respiration to return to regular. This case report demonstrates that even two doses of tramadol administered intravenously may manifest as sudden and prolonged apnea. Respiratory depression with tramadol has been reported in patients with impaired renal functions and Cytochrome P(CYP) 2D6 gene duplication
참고문헌 (12)
- Grond S, "Clinical pharmacology of tramadol", Clin Pharmacokinet, 43, pp.879~923 (2004)
- American Society of Health-System Pharmacists, "Tramadol hydrochloride, In: American Society of Health-System Pharmacists", AHFS Drug Information, 28 (2010)
- American Pharmacists Association, "Venlafaxine, in Drug Information Handbook", pp.1624~1627 (2008), Lexi- Comp®
- Naranjo CA, "A method for estimating the probability of adverse drug reactions", Clin Pharmacol Ther, 30, pp.239~245 (1981)
- Leppert W, "The impact of tramadol and dihydrocodeine treatment on quality of life of patients with cancer pain", Int J Clin Pract, 64, pp.1681~1687 (2010)
- Afshari R, "Tramadol overdose induced seizure, dramatic rise of CPK and acute renal failure", J Pak Med Assoc, 59, pp.178~ (2009)
- Stamer UM, "Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication", Anesth Analg, 107, pp.926~929 (2008)
- ng SK, "Respiratory depression following oral tramadol in a patient with impaired renal function", Pain, 71, pp.111~112 (1997)
- Pandey R, "Prolonged apnea after small single dose of intravenous tramadol", AANA J, 78, pp.110~112 (2010)
- Rollason V, "Pharmacogenetics of analgesics: toward the individualization of prescription", Pharmacogenomics, 9, pp.905~933 (2008)
- Stamer UM, "Impact of CYP2D6 genotype on ostoperative tramadol analgesia", Pain, 105, pp.231~238 (2003)
- Gholami K, "New guideline for tramadol usage following adverse drug reactions reported to the Iranian Pharmacovigilance Center", Pharmacoepidemiol Drug Saf, 16, pp.229~237 (2007)