만성 비암성 통증 환자의 아편유사제 사용
Prescribing Opioids for Chronic Pain
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Opioids are effective analgesics, but they are often difficult to use properly, due mainly to adverse events, such as constipation, respiratory depression, addiction, tolerance, and opioid induced hyperalgesia. In the past, the problem of opioids around the world was usually caused by drugs traded illegally, so there was no need for medical and social attention in Korea. On the other hand, with the dramatic increase in the therapeutic use of opioids, which commenced more than a decade ago, problems caused by legally prescribed drugs have emerged, and now a more serious opioid crisis is being experienced than in the days of illegal drugs. A growing number of patients are chronically prescribed opioids, and a growing number of health care providers and hospitals suffer from problems related to chronic prescription. Currently, in Korea, it is the time to pay serious attention to achieve the safe and effective use of prescribed opioids. This paper consists of the following parts. 1) A summary of the issues related to chronic pain, opioids, and problems associated with the use of opioids. 2) Some case examples the authors’ experienced. 3) Simple guidelines on the use of opioids in the treatment of chronic non-cancer pain are proposed based on the author’s experience and existing literature. These guidelines are by no means comprehensive, and hopefully in the future, related experts will join forces to develop better guidelines.
Abstract
Opioids are effective analgesics, but they are often difficult to use properly, due mainly to adverse events, such as constipation, respiratory depression, addiction, tolerance, and opioid induced hyperalgesia. In the past, the problem of opioids around the world was usually caused by drugs traded illegally, so there was no need for medical and social attention in Korea. On the other hand, with the dramatic increase in the therapeutic use of opioids, which commenced more than a decade ago, problems caused by legally prescribed drugs have emerged, and now a more serious opioid crisis is being experienced than in the days of illegal drugs. A growing number of patients are chronically prescribed opioids, and a growing number of health care providers and hospitals suffer from problems related to chronic prescription. Currently, in Korea, it is the time to pay serious attention to achieve the safe and effective use of prescribed opioids. This paper consists of the following parts. 1) A summary of the issues related to chronic pain, opioids, and problems associated with the use of opioids. 2) Some case examples the authors’ experienced. 3) Simple guidelines on the use of opioids in the treatment of chronic non-cancer pain are proposed based on the author’s experience and existing literature. These guidelines are by no means comprehensive, and hopefully in the future, related experts will join forces to develop better guidelines.
참고문헌 (63)
- Moulin DE, "Chronic pain in Canada--prevalence, treatment, impact and the role of opioid analgesia", Pain Res Manag, 7, pp.179~184 (2002)
- Volkow ND, "Opioid abuse in chronic pain--misconceptions and mitigation strategies", N Engl J Med, 374, pp.1253~1263 (2016)
- 조윤숙, "단일 상급종합병원에서 마약성 진통제의 최근 13년간 사용 경향 조사", 약 학 회 지, 58(4), pp.268~276 (2014), 대한약학회
- "A nurse at Seoul National University Hospital tricked her into taking drugs for patients" (2018)[URL]
- Breivik H, "Survey of chronic pain in Europe : prevalence, impact on daily life, and treatment", Eur J Pain, 10, pp.287~333 (2006)
- Merskey H, "Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms" (1994), IASP Press
- Vlaeyen JW, "The fear-avoidance model of pain", Pain, 157, pp.1588~1589 (2016)
- Merskey H, "Chronic pain: a health policy perspective", pp.19~28 (2008), Wiley-Blackwell
- 윤덕미, "질병의 특성에 따른 진통제의 선택", 대한의사협회지, 54(7), pp.739~746 (2011), 대한의사협회
- Lee YW, "Opioid therapy for chronic nonmaliganat pain", Hanyang Med Rev, 31, pp.70~75 (2011)
- Merskey H, "The definition of pain", Eur Psychiatry, 6, pp.153~159 (1991)
- Gatchel RJ, "The biopsychosocial approach to chronic pain : scientific advances and future directions", Psychol Bull, 133, pp.581~624 (2007)
- Baron R, "Mechanisms of disease : neuropathic pain--a clinical perspective", Nat Clin Pract Neurol, 2, pp.95~106 (2006)
- D’Costa RAFJ, "Cancer pain", pp.109~119 (2013), Springer
- 박수석, "약물요법", 암성 통증 관리-아편유사제, 2010, pp.53(3), 250~257[DOI]
- Lutfy K, "Buprenorphine : a unique drug with complex pharmacology", Curr Neuropharmacol, 2, pp.395~402 (2004)
- Johnson RE, "A controlled trial of buprenorphine treatment for opioid dependence", JAMA, 267, pp.2750~2755 (1992)
- O’Brien CP, "Naltrexone in the treatment of alcoholism : a clinical review", Alcohol, 13, pp.35~39 (1996)
- Chang HM, "Management of chronic pain and opioid dependence with buprenorphine", naloxone, 2018, pp.72, 454~
- Chen KY, "Buprenorphine-naloxone therapy in pain management", Anesthesiology, 120, pp.1262~1274 (2014)
- Furlan AD, "Opioids for chronic noncancer pain : a meta-analysis of effectiveness and side effects", CMAJ, 174, pp.1589~1594 (2006)
- Huxtable CA, "Acute pain management in opioid-tolerant patients : a growing challenge", Anaesth Intensive Care, 39, pp.804~823 (2011)
- Esfahlan AJ, "Burn pain and patients’responses", Burns, 36, pp.1129~1133 (2010)
- Dowell D, "CDC guideline for prescribing opioids for chronic pain--United States, 2016", JAMA, 315, pp.1624~1645 (2016)
- McQuay H, "Oxford textbook of surgery", pp.3521~3532 (2000), Oxford University Press
- 손근숙, "암성통증 약물치료의 최신 경향", 대한의사협회지, 55(7), pp.666~675 (2012), 대한의사협회[DOI]
- "Adult cancer pain. Plymouth Meeting" (2012)[URL]
- Portenoy RK, "Treatment of cancer pain", Lancet, 377, pp.2236~2247 (2011)
- Noble M, "Long-term opioid management for chronic noncancer pain", Cochrane Database Syst Rev, pp.CD006605~ (2010)
- Eriksen J, "Critical issues on opioids in chronic non-cancer pain : an epidemiological study", Pain, 125, pp.172~179 (2006)
- Jadad AR, "The WHO analgesic ladder for cancer pain management. Stepping up the quality of its evaluation", JAMA, 274, pp.1870~1873 (1995)
- Chou R, "The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop", Ann Intern Med, 162, pp.276~286 (2015)
- Manchikanti L, "A systematic review of randomized trials of long-term opioid management for chronic non-cancer pain", Pain Physician, 14, pp.91~121 (2011)
- Busse JW, "Opioids for chronic noncancer pain : a systematic review and metaanalysis", JAMA, 320, pp.2448~2460 (2018)
- Holzer P, "Opioid-induced bowel dysfunction in cancer-related pain : causes, consequences, and a novel approach for its management", J Opioid Manag, 5, pp.145~151 (2009)
- Lötsch J, "Fatal respiratory depression after multiple intravenous morphine injections", Clin Pharmacokinet, 45, pp.1051~1060 (2006)
- Calcaterra S, "National trends in pharmaceutical opioid related overdose deaths compared to other substance related overdose deaths : 1999-2009", Drug Alcohol Depend, 131, pp.263~270 (2013)
- Ladapo JA, "Physician prescribing of opioids to patients at increased risk of overdose from benzodiazepine use in the United States", JAMA Psychiatry, 75, pp.623~630 (2018)
- Bodkin JA, "Buprenorphine treatment of refractory depression", J Clin Psychopharmacol, 15, pp.49~57 (1995)
- Nyhuis PW, "Does the antidepressive response to opiate treatment describe a subtype of depression?", Eur Neuropsychopharmacol, 16(Suppl 4), pp.S309~ (2006)
- Miller M, "Prescription opioid duration of action and the risk of unintentional overdose among patients receiving opioid therapy", JAMA Intern Med, 175, pp.608~615 (2015)
- American Psychiatric Association, "Diagnostic and statistical manual of mental disorders" (2013), APA Publishing
- Park SY, "What is addiction(I) : pathophysiology and therapeutic implications", J Korean Acad Addict Psychiatry, 18, pp.3~16 (2014)
- Wesson DR, "The Clinical Opiate Withdrawal Scale(COWS)", J Psychoactive Drugs, 35, pp.253~259 (2003)
- Kosten TR, "Management of drug and alcohol withdrawal", N Engl J Med, 348, pp.1786~1795 (2003)
- Berna C, "Tapering long-term opioid therapy in chronic noncancer pain : evidence and recommendations for everyday practice", Mayo Clin Proc, 90, pp.828~842 (2015)
- Gowing L, "Alpha2-adrenergic agonists for the management of opioid withdrawal", Cochrane Database Syst Rev, pp.CD002024~ (2014)
- Angst MS, "Opioid-induced hyperalgesia : a qualitative systematic review", Anesthesiology, 104, pp.570~587 (2006)
- Sørensen J, "Cancer pain", pp.131~142 (2013), Springer-Verlag
- Arout CA, "Targeting opioid-induced hyperalgesia in clinical treatment : neurobiological considerations", CNS Drugs, 29, pp.465~486 (2015)
- Benyamin R, "Opioid complications and side effects", Pain Physician, 11(2 Suppl), pp.S105~S120 (2008)
- Juni A, "Morphine hyperalgesia in mice is unrelated to opioid activity, analgesia, or tolerance : evidence for multiple diverse hyperalgesic systems", Brain Res, 1070, pp.35~44 (2006)
- Suzan E, "A negative correlation between hyperalgesia and analgesia in patients with chronic radicular pain : is hydromorphone therapy a double-edged sword", Pain Physician, 16, pp.65~76 (2013)
- Kayan S, "Morphine-induced hyperalgesia in rats tested on the hot plate", J Pharmacol Exp Ther, 177, pp.509~513 (1971)
- Woolf CJ, "Central sensitization: implications for the diagnosis and treatment of pain", Pain, 152(3 Suppl), pp.S2~S15 (2011)
- Vanderah TW, "Mechanisms of opioid-induced pain and antinociceptive tolerance : descending facilitation and spinal dynorphin", Pain, 92, pp.5~9 (2001)
- Vanderah TW, "Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance", J Neurosci, 21, pp.279~286 (2001)
- Li X, "Hyperalgesia during opioid abstinence : mediation by glutamate and substance p", Anesth Analg, 95, pp.979~984 (2002)
- Ji RR, "Central sensitization and LTP : do pain and memory share similar mechanisms", Trends Neurosci, 26, pp.696~705 (2003)
- Mao J, "Opioid-induced abnormal pain sensitivity : implications in clinical opioid therapy", Pain, 100, pp.213~217 (2002)
- Ackerman WE 3rd, "Paroxysmal opioid-induced pain and hyperalgesia", J Ky Med Assoc, 104, pp.419~423 (2006)
- Meyer-Rosberg K, "A comparison of the SF-36 and Nottingham Health Profile in patients with chronic neuropathic pain", Eur J Pain, 5, pp.391~403 (2001)
- 이경규, "만성 통증 환자에서의 정신약물학적 치료", 대한정신약물학회지, 19(2), pp.77~84 (2008), 대한정신약물학회