직장암 환자에서 Oxaliplatin 투여로 인한 혈관부종 발생 증례 보고
Oxaliplatin Induced Angioedema in a Rectal Cancer Patient: A Clinical Case Report
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
We report an unusual case of angioedema induced by intravenous oxaliplatin in a patient with rectal cancer. Intravenous oxaliplatin was administered to the patient according to FOLFOX regimen (oxaliplatin/leucovorin/5-fluorouracil)for the management of his colorectal carcinoma. The patient had been on FOLFOX regimen for several months without reporting any adverse effects, but he experienced angioedema suddenly during his 9^(th) cycle of chemotherapy. Angioedema was observed about 2 hours after the initiation of oxaliplatin infusion. Oxaliplatin was stopped then the patient became stable. This case report demonstrates that intravenous oxaliplatin may induce angioedema several hours after the initiation of oxaliplatin infusion in later cycles of chemotherapy.
Abstract
We report an unusual case of angioedema induced by intravenous oxaliplatin in a patient with rectal cancer. Intravenous oxaliplatin was administered to the patient according to FOLFOX regimen (oxaliplatin/leucovorin/5-fluorouracil)for the management of his colorectal carcinoma. The patient had been on FOLFOX regimen for several months without reporting any adverse effects, but he experienced angioedema suddenly during his 9^(th) cycle of chemotherapy. Angioedema was observed about 2 hours after the initiation of oxaliplatin infusion. Oxaliplatin was stopped then the patient became stable. This case report demonstrates that intravenous oxaliplatin may induce angioedema several hours after the initiation of oxaliplatin infusion in later cycles of chemotherapy.
참고문헌 (13)
- American Society of Health-System Pharmacists, "Oxaliplatin, In American Society of Health-System Pharmacists", pp.10~ (2011), AHFS Drug Information
- American Pharmacists Association, "Oxaliplatin, In American Pharmacists Association. Drug Information Handbook: Lexi- Comp®", pp.1160~1162 (2008)
- Becouarn Y, "Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients", J Clin Oncol, 16, pp.2739~2744 (1998)
- Eloxatin® prescribing information, (2009), LLC
- Andre T, "Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer", N Engl J Med, 350, pp.2343~2351 (2004)
- Thomas RR, "Hypersensitivity and idiosyncratic reactions to oxaliplatin", Cancer, 97, pp.2301~2307 (2003)
- Lenz G, "Adverse reactions to oxaliplatin: a retrospective study of 25 patients treated in one institution", Anti-cancer Drugs, 14, pp.731~733 (2003)
- Naranjo CA, "A method for estimating the probability of adverse drug reactions", Clin Pharmacol Ther, 30, pp.239~245 (1981)
- Levi F, "Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. International Organization for Cancer Chronotherapy", Lancet, 350, pp.681~686 (1997)
- Maindrault-Goebel F, "Allergic-type reactions to oxaliplatin: retrospective analysis of 42 patients", Eur J Cancer, 41, pp.2262~2267 (2005)
- Feldman LD, "Fluorouracil-associated dermatitis of the hands and feet", JAMA, 254, pp.3479~ (1985)
- Budd GT, "5-Fluorouracil and folinic acid in the treatment of metastatic colorectal cancer: a randomized comparison. A Southwest Oncology Group study", J Clin Oncol, 5, pp.272~277 (1987)
- Potenza S, "Severe respiratory symptoms to oxaliplatin infusion: a case report of delayed hypersensitivity reaction", Invest New Drugs, 28, pp.185~186 (2010)
