A Pilot Genome-Wide Association Study Identifies Novel Markers of Metabolic Syndrome in Patients with Psoriasis
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Background: Recent studies have reported that psoriasis is associated with the development of metabolic syndrome. Genome-wide association studies have been used to discover gene variant markers that occur frequently in case group in relation to specific diseases. Objective: The aim of the present study was to investigate the variants of specific genes in- volved in metabolic syndrome associated with psoriasis. Methods: A total of 95 psoriasis patients were recruited and divided into two groups: one with metabolic syndrome (38 patients) and the other without (57 patients). After genotyp- ing, imputation, and quality checking, the association between the several single nucleotide polymorphisms and metabolic syndrome in psoriasis was tested, followed by gene set en- richment analysis. Results: We found 76 gene polymorphisms that conferred an increased risk for metabolic syn- drome in patients with psoriasis. Four single nucleotide polymorphisms (rs17154774 of FR- MD4A, rs77498336 of GPR116 , rs75949580 and rs187682251 of MAPK4) showed the strongest association between metabolic syndrome and psoriasis. The epidermal growth factor receptor protein was located at the center of the protein interactions for the gene polymorphisms. Conclusion: This study identified several previously unknown polymorphisms associated with metabolic syndrome in psoriasis. These results highlight the potential for future ge- netic studies to elucidate the development, and ultimately prevent the onset, of metabolic syndrome in patients with psoriasis.
Abstract
Background: Recent studies have reported that psoriasis is associated with the development of metabolic syndrome. Genome-wide association studies have been used to discover gene variant markers that occur frequently in case group in relation to specific diseases. Objective: The aim of the present study was to investigate the variants of specific genes in- volved in metabolic syndrome associated with psoriasis. Methods: A total of 95 psoriasis patients were recruited and divided into two groups: one with metabolic syndrome (38 patients) and the other without (57 patients). After genotyp- ing, imputation, and quality checking, the association between the several single nucleotide polymorphisms and metabolic syndrome in psoriasis was tested, followed by gene set en- richment analysis. Results: We found 76 gene polymorphisms that conferred an increased risk for metabolic syn- drome in patients with psoriasis. Four single nucleotide polymorphisms (rs17154774 of FR- MD4A, rs77498336 of GPR116 , rs75949580 and rs187682251 of MAPK4) showed the strongest association between metabolic syndrome and psoriasis. The epidermal growth factor receptor protein was located at the center of the protein interactions for the gene polymorphisms. Conclusion: This study identified several previously unknown polymorphisms associated with metabolic syndrome in psoriasis. These results highlight the potential for future ge- netic studies to elucidate the development, and ultimately prevent the onset, of metabolic syndrome in patients with psoriasis.
참고문헌 (34)
- Dand N, "Psoriasis and genetics", Acta Derm Venereol, 100, pp.adv00030~ (2020)
- Perera GK, "Psoriasis", Annu Rev Pathol, 7, pp.385~422 (2012)
- Kamiya K, "Risk factors for the development of psoriasis", Int J Mol Sci, 20, pp.4347~ (2019)
- Hao Y, "Metabolic syndrome and psoriasis : mechanisms and future directions", Front Immunol, 12, pp.711060~ (2021)
- Eckel RH, "The metabolic syndrome", Lancet, 365, pp.1415~1428 (2005)
- Armstrong AW, "Psoriasis and metabolic syndrome : a systematic review and meta-analysis of observational studies", J Am Acad Dermatol, 68, pp.654~662 (2013)
- Koebnick C, "The association of psoriasis and elevated blood lipids in overweight and obese children", J Pediatr, 159, pp.577~583 (2011)
- Gisondi P, "Psoriasis and the metabolic syndrome", Clin Dermatol, 36, pp.21~28 (2018)
- Capon F, "The genetic basis of psoriasis", Int J Mol Sci, 18, pp.2526~ (2017)
- Dehghan A, "Genome-wide association studies", Methods Mol Biol, 1793, pp.37~49 (2018)
- Ellinghaus E, "Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2", Nat Genet, 42, pp.991~995 (2010)
- Oh SW, "Genomewide association study of metabolic syndrome in Korean populations", PLoS One, 15, pp.e0227357~ (2020)
- Alberti KG, "The metabolic syndrome--a new worldwide definition", Lancet, 366, pp.1059~1062 (2005)
- Snekvik I, "Metabolic syndrome and risk of incident psoriasis : prospective data from the HUNT Study, Norway", Br J Dermatol, 180, pp.94~99 (2019)
- Langan SM, "Prevalence of metabolic syndrome in patients with psoriasis : a population-based study in the United Kingdom", J Invest Dermatol, 132(3 Pt 1), pp.556~562 (2012)
- Nisa N, "Prevalence of metabolic syndrome in patients with psoriasis", Indian J Dermatol Venereol Leprol, 76, pp.662~665 (2010)
- Danielsen K, "Elevated odds of metabolic syndrome in psoriasis : a population-based study of age and sex differences", Br J Dermatol, 172, pp.419~427 (2015)
- Liu Y, "Association of polymorphisms of metabolism-related genes with psoriasis vulgaris in Han Chinese", Biomed Res Int, 2021, pp.9920631~ (2021)
- Abdel Hay RM, "Association between the leptin gene 2548G", A polymorphism, the plasma leptin and the metabolic syndrome with psoriasis, 2011, pp.20, 715~719
- Wilkening S, "Is there still a need for candidate gene approaches in the era of genome-wide association studies?", Genomics, 93, pp.415~419 (2009)
- Patnala R, "Candidate gene association studies : a comprehensive guide to useful in silico tools", BMC Genet, 14, pp.39~ (2013)
- Tabor HK, "Candidate-gene approaches for studying complex genetic traits : practical considerations", Nat Rev Genet, 3, pp.391~397 (2002)
- Uffelmann E, "Genome-wide association studies", Nat Rev Methods Primers, 1, pp.59~ (2021)
- Ziegler A, "Study designs and methods post genome-wide association studies", Hum Genet, 131, pp.1525~1531 (2012)
- Ikenouchi J, "FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex", Proc Natl Acad Sci U S A, 107, pp.748~753 (2010)
- Hu J, "Small GTPase Arf6regulates diabetes-induced cholesterol accumulation in podocytes", J Cell Physiol, 234, pp.23559~23570 (2019)
- Yan X, "FRMD4A-cytohesin signaling modulates the cellular release of tau", J Cell Sci, 129, pp.2003~2015 (2016)
- Zhang S, "Identification of prognostic biomarkers for clear cell renal cell carcinoma(ccRCC)by transcriptomics", Ann Clin Lab Sci, 51, pp.597~608 (2021)
- Wang W, "MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT", mTOR signaling, 2019, pp.129, 1015~1029
- Lu W, "Identification of potential osteoporosis miRNA biomarkers using bioinformatics approaches", Comput Math Methods Med, 2021, pp.3562942~ (2021)
- Steri M, "Genetic variants in mRNA untranslated regions", Wiley Interdiscip Rev RNA, 9, pp.e1474~ (2018)
- Wee P, "Epidermal growth factor receptor cell proliferation signaling pathways", Cancers(Basel), 9, pp.52~ (2017)
- Wang S, "Recent advances on the roles of epidermal growth factor receptor in psoriasis", Am J Transl Res, 11, pp.520~528 (2019)
- 김지민, "Serum Soluble Epidermal Growth Factor Receptor Level Increase in Patients Newly Diagnosed with Type 2 Diabetes Mellitus", Diabetes and Metabolism Journal, 42(4), pp.343~347 (2018), 대한당뇨병학회[DOI]