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Association of Metabolic Comorbidities with Pediatric Psoriasis: A Systematic Review and Meta-Analysis

조성진|김예은|조수익
대한피부과학회 (Korean Dermalogical Association)|2021.06|Annals of Dermatology|제33권 제3호|pp. 203-213|DOI 10.5021/ad.2021.33.3.203

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키워드

HypertensionObesityMetabolic syndromeDiabetes mellitusPsoriasis
주제분류피부과학

초록

Background: An evident relationship has been shown between psoriasis and metabolic comorbidities. However, the results in pediatric psoriasis vary from study to study, and no meta-analysis exists on the association of metabolic comorbidities with pediatric psoriasis. Objective: To evaluate the association between psoriasis and metabolic comorbidities in pediatric patients. Methods: We searched articles published in PubMed, EMBASE, and Cochrane Library databases from inception to April 30, 2019. All observational studies reporting the prevalence of obesity or metabolic comorbidities in pediatric patients with psoriasis were included. Results: The meta-analysis included 16 unique studies meeting the inclusion criteria. The pooled odds ratios in pediatric patients with psoriasis was 2.40 (95% confidence interval [CI], 1.60∼3.59) for obesity (13 studies), 2.73 (95% CI, 1.79∼ 4.17) for hypertension (8 studies), 2.01 (95% CI, 1.09∼3.73) for diabetes mellitus (8 studies), 1.67 (95% CI, 1.42∼1.97) for dyslipidemia (7 studies), and 7.49 (95% CI, 1.86∼30.07) for metabolic syndrome (4 studies). Conclusion: Pediatric patients with psoriasis showed a significantly higher prevalence of obesity, hypertension, diabetes, dyslipidemia, and metabolic syndrome. Adequate monitoring and timely management of metabolic comorbidities should be considered in these patients.

Abstract

Background: An evident relationship has been shown between psoriasis and metabolic comorbidities. However, the results in pediatric psoriasis vary from study to study, and no meta-analysis exists on the association of metabolic comorbidities with pediatric psoriasis. Objective: To evaluate the association between psoriasis and metabolic comorbidities in pediatric patients. Methods: We searched articles published in PubMed, EMBASE, and Cochrane Library databases from inception to April 30, 2019. All observational studies reporting the prevalence of obesity or metabolic comorbidities in pediatric patients with psoriasis were included. Results: The meta-analysis included 16 unique studies meeting the inclusion criteria. The pooled odds ratios in pediatric patients with psoriasis was 2.40 (95% confidence interval [CI], 1.60∼3.59) for obesity (13 studies), 2.73 (95% CI, 1.79∼ 4.17) for hypertension (8 studies), 2.01 (95% CI, 1.09∼3.73) for diabetes mellitus (8 studies), 1.67 (95% CI, 1.42∼1.97) for dyslipidemia (7 studies), and 7.49 (95% CI, 1.86∼30.07) for metabolic syndrome (4 studies). Conclusion: Pediatric patients with psoriasis showed a significantly higher prevalence of obesity, hypertension, diabetes, dyslipidemia, and metabolic syndrome. Adequate monitoring and timely management of metabolic comorbidities should be considered in these patients.

참고문헌 (65)

  1. Parisi R, "Global epidemiology of psoriasis: a systematic review of incidence and prevalence", J Invest Dermatol, 133, pp.377~385 (2013)
  2. Yeung H, "Psoriasis severity and the prevalence of major medical comorbidity : a population-based study", JAMA Dermatol, 149, pp.1173~1179 (2013)
  3. Brauchli YB, "Psoriasis and the risk of incident diabetes mellitus : a population-based study", Br J Dermatol, 159, pp.1331~1337 (2008)
  4. Brauchli YB, "Psoriasis and risk of incident myocardial infarction, stroke or transient ischaemic attack: an inception cohort study with a nested case-control analysis", Br J Dermatol, 160, pp.1048~1056 (2009)
  5. Baeta IG, "Comorbidities and cardiovascular risk factors in patients with psoriasis", An Bras Dermatol, 89, pp.735~744 (2014)
  6. Obunai K, "Cardiovascular morbidity and mortality of the metabolic syndrome", Med Clin North Am, 91, pp.1169~1184 (2007)
  7. Burden-Teh E, "The epidemiology of childhood psoriasis : a scoping review", Br J Dermatol, 174, pp.1242~1257 (2016)
  8. Horton DB, "Antibiotic exposure, infection, and the development of pediatric psoriasis: a nested case-control study", JAMA Dermatol, 152, pp.191~199 (2016)
  9. US Preventive Services Task Force, "Screening for obesity in children and adolescents: US Preventive Services Task Force recommendation statement", JAMA, 317, pp.2417~2426 (2017)
  10. Halpern A, "Metabolic syndrome, dyslipidemia, hypertension and type 2 diabetes in youth:from diagnosis to treatment", Diabetol Metab Syndr, 2, pp.55~ (2010)
  11. Kimball AB, "Risks of developing psychiatric disorders in pediatric patients with psoriasis", J Am Acad Dermatol, 67, pp.651~657 (2012)
  12. Torres T, "Cardiovascular comorbidities in childhood psoriasis", Eur J Dermatol, 24, pp.229~235 (2014)
  13. Augustin M, "Epidemiology and comorbidity in children with psoriasis and atopic eczema", Dermatology, 231, pp.35~40 (2015)
  14. Osier E, "Pediatric psoriasis comorbidity screening guidelines", JAMA Dermatol, 153, pp.698~704 (2017)
  15. Takeshita J, "Psoriasis and comorbid diseases : epidemiology", J Am Acad Dermatol, 76, pp.377~390 (2017)
  16. Armstrong AW, "The association between psoriasis and obesity : a systematic review and meta-analysis of observational studies", Nutr Diabetes, 2, pp.e54~ (2012)
  17. Armstrong AW, "The association between psoriasis and hypertension : a systematic review and meta-analysis of observational studies", J Hypertens, 31, pp.433~442 (2013)
  18. Armstrong AW, "Psoriasis and the risk of diabetes mellitus : a systematic review and metaanalysis", JAMA Dermatol, 149, pp.84~91 (2013)
  19. Armstrong AW, "Psoriasis and metabolic syndrome : a systematic review and meta-analysis of observational studies", J Am Acad Dermatol, 68, pp.654~662 (2013)
  20. Stroup DF, "Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group", JAMA, 283, pp.2008~2012 (2000)
  21. Miller IM, "Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors", J Am Acad Dermatol, 69, pp.1014~1024 (2013)
  22. Egger M, "Bias in meta-analysis detected by a simple, graphical test", BMJ, 315, pp.629~634 (1997)
  23. Zhu KJ, "Relationship of the body mass index and childhood psoriasis in a Chinese Han population : a hospital-based study", J Dermatol, 39, pp.181~183 (2012)
  24. Paller AS, "Association of pediatric psoriasis severity with excess and central adiposity : an international crosssectional study", JAMA Dermatol, 149, pp.166~176 (2013)
  25. Mahé E, "Psoriasis and obesity in French children: a case-control, multicentre study", Br J Dermatol, 172, pp.1593~1600 (2015)
  26. Tom WL, "Characterization of lipoprotein composition and function in pediatric psoriasis reveals a more atherogenic profile", J Invest Dermatol, 136, pp.67~73 (2016)
  27. Lee A, "Association between pediatric psoriasis and waist-to-height ratio in the absence of obesity : a multicenter Australian study", JAMA Dermatol, 152, pp.1314~1319 (2016)
  28. Choon SE, "Clinico-epidemiological profile, including body mass index of Malaysian children with psoriasis", Med J Malaysia, 71, pp.171~176 (2016)
  29. Kwa L, "Cardiovascular comorbidities of pediatric psoriasis among hospitalized children in the United States", J Am Acad Dermatol, 77, pp.1023~1029 (2017)
  30. Ergun T, "Prevalence of obesity in paediatric psoriasis and its impact on disease severity and progression", Australas J Dermatol, 58, pp.e182~e187 (2017)
  31. Hunjan MK, "Association between obesity and pediatric psoriasis", Pediatr Dermatol, 35, pp.e304~e305 (2018)
  32. Paller AS, "A retrospective cohort study to evaluate the development of comorbidities, including psychiatric comorbidities, among a pediatric psoriasis population", Pediatr Dermatol, 36, pp.290~297 (2019)
  33. Caroppo F, "High blood pressure in normal-weight children with psoriasis", Acta Derm Venereol, 99, pp.329~330 (2019)
  34. Cohen AD, "Psoriasis and diabetes : a populationbased cross-sectional study", J Eur Acad Dermatol Venereol, 22, pp.585~589 (2008)
  35. Goldminz AM, "Prevalence of the metabolic syndrome in children with psoriatic disease", Pediatr Dermatol, 30, pp.700~705 (2013)
  36. Tollefson MM, "Association of psoriasis with comorbidity development in children with psoriasis", JAMA Dermatol, 154, pp.286~292 (2018)
  37. de Ferranti SD, "Prevalence of the metabolic syndrome in American adolescents : findings from the Third National Health and Nutrition Examination Survey", Circulation, 110, pp.2494~2497 (2004)
  38. Zimmet P, "The metabolic syndrome in children and adolescents-an IDF consensus report", Pediatr Diabetes, 8, pp.299~306 (2007)
  39. Ma C, "The association between psoriasis and dyslipidaemia : a systematic review", Br J Dermatol, 168, pp.486~495 (2013)
  40. Lønnberg AS, "Association of psoriasis with the risk for type 2diabetes mellitus and obesity", JAMA Dermatol, 152, pp.761~767 (2016)
  41. Gisondi P, "Psoriasis and the metabolic syndrome", Clin Dermatol, 36, pp.21~28 (2018)
  42. Lu Y, "Association of cardiovascular and metabolic disease genes with psoriasis", J Invest Dermatol, 133, pp.836~839 (2013)
  43. Boehncke WH, "The ‘psoriatic march’ : a concept of how severe psoriasis may drive cardiovascular comorbidity", Exp Dermatol, 20, pp.303~307 (2011)
  44. Armstrong EJ, "Psoriasis and major adverse cardiovascular events : a systematic review and meta-analysis of observational studies", J Am Heart Assoc, 2, pp.e000062~ (2013)
  45. Takeshita J, "Psoriasis and comorbid diseases : implications for management", J Am Acad Dermatol, 76, pp.393~403 (2017)
  46. Danielsen K, "Overweight and weight gain predict psoriasis development in a population-based cohort", Acta Derm Venereol, 97, pp.332~339 (2017)
  47. Naldi L, "Impact of body mass index and obesity on clinical response to systemic treatment for psoriasis. Evidence from the Psocare project", Dermatology, 217, pp.365~373 (2008)
  48. Puig L, "Obesity and psoriasis: body weight and body mass index influence the response to biological treatment", J Eur Acad Dermatol Venereol, 25, pp.1007~1011 (2011)
  49. Bronckers IM, "Psoriasis in children and adolescents: diagnosis, management and comorbidities", Paediatr Drugs, 17, pp.373~384 (2015)
  50. Badaoui A, "Psoriasis and metabolic and cardiovascular comorbidities in children : a systematic review", Arch Pediatr, 26, pp.86~94 (2019)
  51. Eichenfield LF, "Pediatric psoriasis : evolving perspectives", Pediatr Dermatol, 35, pp.170~181 (2018)
  52. Wild S, "Global prevalence of diabetes : estimates for the year 2000 and projections for 2030", Diabetes Care, 27, pp.1047~1053 (2004)
  53. Hansen ML, "Underdiagnosis of hypertension in children and adolescents", JAMA, 298, pp.874~879 (2007)
  54. Reilly JJ, "Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review", Int J Obes (Lond), 35, pp.891~898 (2011)
  55. Falkner B, "Hypertension in children and adolescents: epidemiology and natural history", Pediatr Nephrol, 25, pp.1219~1224 (2010)
  56. Pinhas-Hamiel O, "Acute and chronic complications of type 2 diabetes mellitus in children and adolescents", Lancet, 369, pp.1823~1831 (2007)
  57. Pappadis SL, "Hypertension in adolescents : a review of diagnosis and management", Curr Opin Pediatr, 15, pp.370~378 (2003)
  58. Wong J, "Timing is everything: age of onset influences long-term retinopathy risk in type 2 diabetes, independent of traditional risk factors", Diabetes Care, 31, pp.1985~1990 (2008)
  59. Donaghue KC, "qMicrovascular and macrovascular complications associated with diabetes in children and adolescents", Pediatr Diabetes, 10(Suppl 12), pp.195~203 (2009)
  60. Schmidt MD, "Childhood fitness reduces the long-term cardiometabolic risks associated with childhood obesity", Int J Obes(Lond), 40, pp.1134~1140 (2016)
  61. Cohen JB, "Cardiovascular and renal effects of weight reduction in obesity and the metabolic syndrome", Curr Hypertens Rep, 17, pp.34~ (2015)
  62. Eder L, "Association of tumor necrosis factor inhibitor treatment with reduced indices of subclinical atherosclerosis in patients with psoriatic disease", Arthritis Rheumatol, 70, pp.408~416 (2018)
  63. Hjuler KF, "Association between changes in coronary artery disease progression and treatment with biologic agents for severe psoriasis", JAMA Dermatol, 152, pp.1114~1121 (2016)
  64. Elnabawi YA, "Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis : results from a prospective observational study", Cardiovasc Res, 115, pp.721~728 (2019)
  65. Elnabawi YA, "Association of biologic therapy with coronary inflammation in patients with psoriasis as assessed by perivascular fat attenuation index", JAMA Cardiol, 4, pp.885~891 (2019)

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