Laparoscopic Cholecystectomy 수술 후 Sugammadex와 Neostigmine 간에 첫 자발호흡과 부작용 발현 연구
Comparison of Sugammadex and Neostigmine on First Spontaneous Breathing and Adverse Effects for Laparoscopic Cholecystectomy
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Objective: The purpose of the study was to investigate the time from the injection of muscle relaxants to the first spontaneousrespiration between sugammadex and conventional reversal for patients undergoing laparoscopic cholecystectomy. Methods: Thisstudy was retrospectively conducted on patients who were diagnosed with gallbladder stone (N802) between January 2014 andApril 2017. The data were collected from the electronic medical records of a total of 186 patients (84 patients in the neostigminegroup and 102 patients in the sugammadex group). Results: The time required for the first spontaneous respiration in thesugammadex group was shorter than that in the neostigmine group (3.6 min vs 4.9 min; p<0.05). After the injection of intermediatemuscle relaxants, the comparison of heart rate and mean arterial pressure in the sugammadex and neostigmine groups revealedthat the heart rate in the neostigmine group was higher than in the sugammadex group after 5 min (p<0.05). The mean arterialpressure in the neostigmine group was higher than in the sugammadex group after 10 min (p<0.05). A significant adverse effect oftachycardia was observed in the neostigmine group (p<0.05), but the frequency of rescue antiemetic in the sugammadex group wassignificantly higher than in the neostigmine group (p<0.05). Conclusion: In this study, the unwanted effect of neostigmine group wastachycardia; therefore, in the case of patients with hemodynamic instability, sugammadex is recommended. At 12 hours after theinjection of sugammadex to patients, more antiemetics were required than in the neostigmine group; therefore, more researchshould be conducted on postoperative nausea and vomiting.
Abstract
Objective: The purpose of the study was to investigate the time from the injection of muscle relaxants to the first spontaneousrespiration between sugammadex and conventional reversal for patients undergoing laparoscopic cholecystectomy. Methods: Thisstudy was retrospectively conducted on patients who were diagnosed with gallbladder stone (N802) between January 2014 andApril 2017. The data were collected from the electronic medical records of a total of 186 patients (84 patients in the neostigminegroup and 102 patients in the sugammadex group). Results: The time required for the first spontaneous respiration in thesugammadex group was shorter than that in the neostigmine group (3.6 min vs 4.9 min; p<0.05). After the injection of intermediatemuscle relaxants, the comparison of heart rate and mean arterial pressure in the sugammadex and neostigmine groups revealedthat the heart rate in the neostigmine group was higher than in the sugammadex group after 5 min (p<0.05). The mean arterialpressure in the neostigmine group was higher than in the sugammadex group after 10 min (p<0.05). A significant adverse effect oftachycardia was observed in the neostigmine group (p<0.05), but the frequency of rescue antiemetic in the sugammadex group wassignificantly higher than in the neostigmine group (p<0.05). Conclusion: In this study, the unwanted effect of neostigmine group wastachycardia; therefore, in the case of patients with hemodynamic instability, sugammadex is recommended. At 12 hours after theinjection of sugammadex to patients, more antiemetics were required than in the neostigmine group; therefore, more researchshould be conducted on postoperative nausea and vomiting.
참고문헌 (12)
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