한국 성인에서의 음주와 hsCRP의 관련성
Association between Alcohol Consumption and hsCRP in Korean Adults
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연구배경: 심혈관 질환은 전체 사망원인의 21.2%로 주요 사망원인 중 하나이다. 많은 나라에서 적당량의 음주가 심혈관 질환의 발생을 줄인다는 연구가 보고되고 있으며, 심혈관 질환의 위험도를 객관적으로 평가할 수 있는 생화학적 염증표지자로 hsCRP (high sensitivity C-reactive protein)의 유용성이 인정받고 있다. 본 연구는 우리나라 성인에서 음주량와 hsCRP의 관련성에 대해서 조사하였다. 방법: 2006년 5월부터 6월까지 한 대학병원 종합건강검진센터를 방문한 남성 769명, 여성 449명, 총 1,218명을 대상으로 신체계측 및 혈압측정과 과거력, 현병력, 음주력에 대한 설문조사 및 hsCRP, 총콜레스테롤, 고밀도지단백, 중성지방을 측정하기 위해 혈액검사를 시행하였다. 대상자를 음주량과 음주횟수에 따라 남성에서는 4군, 여성에서는 3군으로 나누어 분석하였으며, 흡연, 혈압, 체질량지수, 나이, 총콜레스테롤, 중성지방, 고밀도지단백 등 hsCRP에 영향을 끼치는 요인을 보정한 후에 음주량이 hsCRP에 미치는 영향을 알아보기 위해 일반선형모델(GLM)을 이용한 공분산분석과 경향분석을 시행하였다. 결과: 음주량에 따른 분석 시에는 남성에서는 일주일에 1∼4잔을 마신 군에서 가장 낮은 hsCRP 값을 보였고 그 이전과 이후 다시 상승하는 U자형을 나타내었다(P for U-shape trend test=0.059). 여성에서는 음주량이 증가할수록 hsCRP 값은 감소하였다(P for linear trend test=0.0002). 결론: 남성에서 음주량과 hsCRP는 U자형의 관계를 보였으며, 여성에서는 반비례 관계를 나타냈다.
Abstract
Association between Alcohol Consumption and hsCRP in Korean AdultsYang Hyun Jo, M.D., Eun Young Choi, M.D.†, Yoo Seock Cheong, M.D., Eal Whan Park, M.D., Jae Hun Kim, M.D.* Background: Cardiovascular diseases are major cause of death. In many countries, several studies reported moderate alcohol drink reduces cardiovascular diseases. High sensitivity C-reactive protein (hsCRP) is useful as a biochemical marker that can evaluate the risk of cardiovascular diseases. This study investigated the association between alcohol consumption and hsCRP. Methods: The subjects included 769 men and 449 women who had visited a health promotion center in one university hospital from May 2006 to June 2006. They responded to self-reported questionnaire on past medical history, quantity and frequency of alcohol intake. Blood sample was taken to examine hsCRP, total cholesterol, HDL cholesterol, and triglyceride. The participants were classified into 4 groups in males and 3 groups in females by alcohol intake quantity. Using general linear model, analysis of covariance was done to evaluate the association between hsCRP and alcohol intake quantity after adjusting for smoking, body mass index, blood pressure, age, total cholesterol, HDL cholesterol, and triglycerides. Results: Men who had drunk 1∼4 drinks weekly had the lowest hsCRP. And a U-shaped correlation between alcohol intake quantity and hsCRP was found (P for U- shape trend test=0.059). In women, hsCRP decreased as the alcohol intake quantity increased (P for linear trend test= 0.0002). Conclusion: In Korean males, U-shaped relationship was found between hsCRP and alcohol intake quantity. In Korean females, inverse relationship was found between them. (J Korean Acad Fam Med 2007;28:768-773)
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