대사증후군과 염증관련인자로서 C-반응단백의 역할
The Role of C-reactive Protein as a Infl ammation-related Factor in Metabolic Syndrome
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연구배경: 대사증후군은 병태생리 상 인슐린저항성, 이상지 질혈증, 고혈압 및 복부비만 등 다양한 위험요인들의 군집으 로 보고되고 있으며, 동맥경화증 및 심혈관계 위험성 측면에 서 염증관련인자들과의 관계에 대한 연구 또한 다수 보고되 어왔다. 본 연구는 상관분석 및 요인분석을 통해 한국인의 대 사증후군에서 hs-CRP의 역할을 알아보았다. 방법: 2004년 5월부터 2005년 3월까지 일개 대학병원 건강증 진센터를 방문한 수진자 중 20세 이상 성인 중 순환기, 호흡 기, 내분비 질환 환자 및 흡연자는 제외한 3,348명(남 1,512명, 여 1,836명)을 대상으로 하였다. 대사증후군의 기준은 NCEP ATP-Ⅲ와 아시아-태평양 보고서의 허리둘레 기준에 따랐다. 통계적 분석은 상관분석 및 요인분석을 시행하였으며, 대사 증후군에서 hs-CRP의 역할 및 남녀 간의 차이를 살펴 보았다. 결과: 표본 집단 중 대사증후군은 총 412명(남 180명, 여 232 명)으로 유병률은 12.31%(남 11.90%, 여 12.64%)이었다. 상관 분석에서 hs-CRP는 여성에서는 인슐린저항성 등 대사관련 인 자들과 상관관계가 높게 나타났으나, 남성에서는 유의한 상 관관계가 없었다. 요인분석에서 남자의 경우 3개(비만요인, 혈압요인, 인슐린저항성요인), 여성의 경우 4개(비만요인, 혈 압요인, 인슐린저항성요인, 이상지질혈증요인)의 요인이 얻 어졌다. hs-CRP는 여성에서 이상지질혈증요인을 형성하고 있 었다. 결론: 대사증후군에 관련된 인자들과 요인분석을 시행하였 을 때 hs-CRP는 남성에서는 의미있는 요인에 포함되지 못했 고, 여성에서만 이상지질혈증 요인에 포함되었다.
Abstract
Background: The metabolic syndrome has been known as the cluster of insulin resistance, dyslipidemia, hypertension, and abdominal obesity. There have been many studies about the infl ammatory role in atherosclerosis and cardiovascular diseases, also. We aimed to elucidate the role of high sensitivity C-reactive protein (hs-CRP) as a infl ammation-related factor in metabolic syndrome in Korean adults by correlation and factor analysis. Methods: A cross sectional study was carried out in 1,512 men and 1,836 women (over 20 years old) who had an examination at a center for health promotion of an university hospital from May 2004 through March 2005. The NCEPATP Ⅲ definition and Asian-Pacific adjusted criteria were used to obtain the metabolic syndrome group. And we evaluated the role and gender difference of hs-CRP in metabolic syndrome by correlation and factor analysis. Results: In women, hs-CRP was statistically correlated with most metabolic variables, especially insulin resistance. In factor analysis, 3 factors (obesity, blood pressure, and insulin resistance) were obtained in men and 4 factors (obesity, blood pressure, insulin resistance, and dyslipidemia) in women, respectively. In women, hs-CRP was a part of dyslipidemia factor. Conclusion: In factor anaylsis of metabolic syndrome factors with hs-CRP, hs-CRP was not a signifi cant factor in men, but was included as a part of dyslipidemia factor in women.
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