한국 소아 청소년의 대사증후군 유병률 - IDF 소아 청소년 대사증후군 진단기준에 의하여
Prevalence of the Metabolic Syndrome in Korean Children and Adolescents according to the International Diabetes Federation Definition in Children and Adolescents
2
조회
0
다운로드
19
인용
0
참고문헌
키워드
초록
연구배경: 소아 청소년 비만과 비만 관련 대사 이상의 증가 로 많은 소아 청소년들이 심혈관계 질환의 위험에 노출되 어 있다. 대사증후군은 심혈관계 질환의 위험이 증가된 소아 를 확인하는데 유용한 개념이다. 그러나 소아 청소년 대사증 후군에 대한 확립된 진단기준이 없어, 소아 청소년 대사증후 군에 대한 연구를 진행하거나, 임상에 적용하는데 어려움이 있었다. 2007년에 주요 단체 중에서는 처음으로 International Diabetes Federation (IDF)에서 소아 청소년 대사증후군의 진단 기준을 발표하였다. 이에 본 연구는 새롭게 제시된 IDF 소아 청소년 대사증후군 진단기준을 사용하여 2005년 국민건강영 양조사에 참여한 10-19세 한국 소아와 청소년의 대사증후군 유병률을 알아보기 위해 수행되었다. 방법: 2005년 국민건강영양조사 검진조사에 참여한 10-19세 소아 청소년 931명을 대상으로 IDF 소아청소년 대사증후군 진단기준을 이용하여 대사증후군 및 대사증후군의 각 대사이 상들의 유병률을 계산하였다. 결과: 2005년 국민건강영양조사에 참여한 10-19세 한국 소 아 청소년의 대사증후군 유병률(±표준오차)은 2.0±0.5% (남 자: 3.1±0.8%, 여자: 0.8±0.4%)였다. 대사증후군으로 진단된 소 아 청소년의 약 95%가 비만아이었으며, 정상체중인 소아 청소 년은 단 한 명도 대사증후군으로 진단되지 않았다. 결론: 2005년 한국 소아 청소년의 IDF 진단기준에 의한 대사 증후군 유병률은 2.0±0.5%였다. IDF에서 제시한 소아 청소년 대사증군 진단기준은 심혈관계 질환의 위험이 증가된 소아 청소년을 확인하고, 예방 및 치료를 하는 데에 도움을 줄 것으로 생각된다. 그러나 IDF 소아 청소년 대사증후군 진단기준 및 각 대사이상의 절단값이 한국 소아 청소년에게 적합한 지에 대해서는 추후 연구가 진행되어야 할 것이다.
Abstract
Background: Many children and adolescents are exposed to the risk of cardiovascular diseases because of increase in obesity and obesity-related metabolic derangements in children and adolescents. The diagnosis of the metabolic syndrome is useful to identify these children with high cardiovascular risk. In 2007, the International Diabetes Federation (IDF) presented a new defi nition of the metabolic syndrome for children and adolescents. The aim of this study was to estimate the prevalence of the metabolic syndrome using the IDF pediatric defi nition in Korean children and adolescents. Methods: We used data from 931 participants aged 10-19 years in the Korean National Health and Nutrition Examination Survey 2005. The metabolic syndrome was diagnosed by the new IDF pediatric defi nition. Results: The prevalence of the metabolic syndrome in Korean children and adolescents aged 10-19 years was 2.0 ± 0.5% (boys: 3.1 ± 0.8%, girls: 0.8 ± 0.4%). Approximately 95% of children and adolescents with the metabolic syndrome was classifi ed with obesity and none of the normal-weighted participants were diagnosed with the metabolic syndrome. Conclusion: The prevalence of the metabolic syndrome in Korean children and adolescents was 2.0 ± 0.5%. It is expected that the new IDF pediatric defi nition will help to detect children with high cardiovascular risk early and to manage them properly. However, whether the IDF pediatric defi nition of the metabolic syndrome and cut-off points of its components are appropriate for Korean children and adolescents should be answered through future research.
참고문헌 (30)
- Reaven GM, "Banting lecture 1988. Role of insulin resistance in human diseas", Diabetes, 37, pp.1595~1607 (1988)
- Isomaa B, "Cardiovascular morbidity and mortality associated with the metabolic syndrome", Diabetes Care, 24, pp.683~689 (2001)
- Wilson PW, "Metabolic sydnrome as a precursor of cardiovascular disease and type 2 diabetes mellitus", Circulation, 112, pp.3066~3072 (2005)
- Lim S, "Korean National Health and Nutrition Examination Surveys. Changes in the characteristics of metabolic syndrome in Korea over the period 1998-2001 as determined by Korean National Health and Nutrition Examination Surveys", Diabetes Care, 28, pp.1810~1812 (2005)
- Ford ES, "Increasing prevalence of the metabolic syndrome among U.S. Adults", Diabetes Care, 27, pp.2444~2449 (2004)
- Alberti KG, "Defenition, diagnosis and classifi cation of diabetes mellitus and its complications. part 1: diagnosis and classifi cation of diabetes mellitus provisional report of a WHO consultation", Diabet Med, 15, pp.539~553 (1998)
- Alberti KG, "IDF Epidemiology Task Force Consensus Group. The metabolic syndrome: a new worldwide definition", Lancet, 366, pp.1059~1062 (2005)
- Grundy SM, "Diagnosis and management of the metabolic syndrome: an American Heart Association", National Heart, Lung, and Blood Institute Scientific Statement, 2005, pp.112, 2735~2752
- Popkin BM, "Is there a lag globally in overweight trends for children compared with adults?", Obesity, 14, pp.1846~1853 (2006)
- 박영신, "23년간 서울 지역 초·중·고등학생의 비만 추이", Korean Journal of Pediatrics, 47(3), pp.247~257 (2004), 대한소아과학회
- Styne DM, "Childhood and adolescent obesity. Prevalence and signifi cance", Pediatr Clin North Am, 48, pp.823~854 (2001)
- Srinivasan SR, "Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study", Metabolism, 45, pp.235~240 (1996)
- Webber LS, "Tracking of serum lipids and lipoproteins from childhood to adulthood. The Bogalusa Heart Study", Am J Epidemiol, 133, pp.884~899 (1991)
- Cook S, "Prevalence of a metabolic syndrome phenotype in adolescents:findings from the third National Health and Nutrition Examination Survey, 1988-1994", Arch Pediatr Adolesc Med, 157, pp.821~827 (2003)
- de Ferranti SD, "Prevalence of the metabolic syndrome in american adolescents: findings from the Third National Health and Nutrition Examination Survey", Cirulation, 110, pp.2494~2497 (2004)
- Cruz ML, "The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity", J Clin Endocrinol Metab, 89, pp.108~113 (2004)
- Seo SJ, "A study on the prevalence and the risk factors of metabolic syndrome in Korean children and adolescents", 박사, pp.2007
- Zimmet P, "The metabolic syndrome in children and adolescents", Lancet, 369, pp.2059~2061 (2007)
- Ford ES, "Prevalence of the metabolic syndrome among U.S. adolescents using the defi nition from the International Diabetes Federation", Diabetes Care, 31, pp.587~589 (2008)
- "The Third Korea National Health and Nutrition Examination Survey (KNHANES III), 2005" (2006)[URL]
- "The Korean Pediatric Society, The Committee for the Development of Growth Standard for Korean Children and Adolescents. 2007 Korean Children and Adolescent national growth chart : Commentary" (2007)[URL]
- Lee SY, "Appropriate waist circumference cutoff points for central obesity in Korean adults", Diabetes Res Clin Pract, 75, pp.72~80 (2007)
- 서민정, "한국 소아와 청소년에서 대사증후군의 유병률", 가정의학회지, 27(10), pp.798~806 (2006), 대한가정의학회
- Seong EJ, "A metabolic syndrome phenotype in Korean children & adolescents: prevalence and change in characteristics over the period 1998-2001", 박사, pp.2007
- Kahn R, "American Diabetes Association; European Association for the Study of Diabetes. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes", Diabetes Care, 28, pp.2289~2304 (2005)
- Yoon YS, "The new definition of metabolic syndrome by the international diabetes federation is less likely to identify metabolically abnormal but non-obese individuals than the defi nition by the revised national cholesterol education program: the Korea NHANES Study", Int J Obes (Lond), 31, pp.528~534 (2007)
- Khoo CM, "The impact of central obesity as a prerequisite for the diagnosis of metabolic syndrome", Obesity (Silver spring), 15, pp.262~269 (2007)
- Daniels SR, "Association of body fat distribution and cardiovascular risk factors in children and adolescents", Circulation, 99, pp.541~545 (1999)
- Li Y, "Prevalence of the metabolic syndrome in Chinese adolescents", Br J Nutr, 99, pp.565~570 (2008)
- Brambilla P, "Metabolic risk-factor clustering estimation in children: to draw a line across pediatric metabolic syndrome", Int J Obes (Lond), 31, pp.591~600 (2007)