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한국 성인 남녀에서 헬리코박터 파이로리감염과 대사증후군과의 관련성

The Association between Helicobacter Pylori Infection and Metabolic Syndrome in Korean Men and Women

최정헌|김창섭|김문찬|정태흠
대한가정의학회 (The Korean Academy Of Family Medicine)|2010.02|Korean Journal of Family Medicine|제31권 제2호|pp. 124-133

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참고문헌

키워드

헬리코박터 파이로리; IgG항체; 대사증후군Helicobacter Pylori; IgG Antibody; Metabolic Syndrome
주제분류가정의학

초록

연구배경: 대사증후군은 심혈관질환과 당뇨병의 위험성을 증가시키는 대사이상의 조합이며 헬리코박터 감염이 대사증후군의 발생과 관련될 가능성이 있어서 이를 규명하기 위해 연구를 시행하였다. 방법: 2008년 3월부터 2009년 2월 사이에 울산광역시의 한 대학병원의 건강증진센터에서 건강검진을 받은 성인 17,448명의 검진결과를 분석하였다. 대상자들을 남녀로 나누어 헬리코박터 파이로리 IgG항체 유무를 독립변수로 하고 대사증후군의 구성요소들을 각각 종속변수로 하여 선형 회귀분석을 이용하여 분석하였고 대사증후군유무를 종속변수로 하여 로지스틱 회귀분석을 이용하여 분석하였다. 결과: 남자에서 헬리코박터 감염이 있을 때 고밀도 지단백콜레스테롤이 유의하게 감소되었으나(회귀계수, -0.02; 95% 신뢰구간, -0.03--0.004; P=0.01) 헬리코박터 감염과 대사증후군유무 사이에는 남녀모두에서 유의한 관련성이 없었다(남 교차비, 1.01; 95% 신뢰구간, 0.90-1.14; P=0.81; 여 교차비, 0.75; 95% 신뢰구간, 0.55-1.02; P=0.06). 결론: 헬리코박터 파이로리 감염은 남자에서 고밀도 지단백콜레스테롤의 감소와 유의한 관련성이 있었으나 대사증후군의 존재와는 남녀모두에서 유의한 관련성이 없었다.

Abstract

Background: Metabolic syndrome is a cluster of metabolic abnormalities leading diabetes and cardiovascular diseases. Helicobacter pylori (H. pylori) infection is suggested to be a risk factor of cardiovascular diseases. We aimed to investigate the association between H. pylori infection and metabolic syndrome. Methods: This study was designed with Korean adults having a health check-up in a university hospital in Ulsan from March 2008 to February 2009. The subjects were 17,448 over 20 years old. The analysis was undertaken according to sex separately. The association of H. pylori seropositivity (IgG) with metabolic syndrome components was investigated by multiple linear regression analysis. The association of H. pylori seropositivity with metabolic syndrome was investigated by multiple logistic regression analysis. Results: H. pylori seropositivity was significantly inversely associated with high density lipoprotein cholesterol in men (Coefficient, -0.02; 95% confidence interval [CI], -0.03 to -0.004; P = 0.01). However, H. pylori seropositivity was not significantly associated with metabolic syndrome in both men and women (OR, 1.01; 95% CI, 0.90 to 1.14; P = 0.81 for men; OR, 0.75; 95% CI, 0.55 to 1.02; P = 0.06 for women). Conclusion: H. pylori infection was significantly negatively associated with high density lipoprotein cholesterol in men, but not significantly associated with metabolic syndrome in both men and women.

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