성인의 일일 칼슘섭취량과 혈중 호모시스테인 농도와의 관계
The Relationship between Daily Calcium Intake and Plasma Homocysteine Concentrations in Adults
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연구배경: 혈중 호모시스테인이 상승할 경우 각종 심혈관계 질환의 위험이 증가하게 된다. 따라서 이를 예방하기 위해 혈중혈중 호모시스테인을 감소시킬 필요성이 대두되고 있고, 비타민 B12, folic acid 등이 효과적인 대안으로 제시되고 있고 최근에는 folic acid, 비타민 B12와 함께 칼슘을 강화시킨 물을 마셨을 때 혈중 호모시스테인 수치가 감소함을 밝힌 여러 연구들도 있다. 본 연구에서는 일일 칼슘섭취량과 혈중 호모시스테인과의 관계를 살펴보고자 하였다. 방법: 2006년 5월부터 2007년 4월까지 일개 대학병원 건강증진센터를 내원한 40세에서 69세까지의 636명의 대상자들 중 설문기입이 완전하지 못한 69명을 제외한 567명을 대상으로 하였다. 자기 기입식 설문과 문진을 통해 인구사회학적 특성과 칼슘섭취량을 알아보았고 신체 검진 및 계측을 통해 키와 체중을 측정하였다. 혈액 검사를 통하여 중성지방, 총 콜레스테롤, 고밀도 콜레스테롤, 저밀도 콜레스테롤, 크리아티닌 및 호모시스테인 농도를 측정하였다. 결과: 총 567명의 대상자들의 일일 칼슘섭취량은 770.1±266.3 mg이었고 평균 호모시스테인은 10.6±4.3 mol/L이었다. 다중회귀분석에서 호모시스테인은 체질량지수, 칼슘섭취량 및 혈중 크레아티닌 농도와 유의한 관계가 있었고 칼슘섭취량이 증가할수록 혈중 호모시스테인 농도가 감소하는 것으로 나타났다. 결론: 성인에서 칼슘섭취량이 증가할수록 혈관질환의 독립적인 위험인자 중 하나인 호모시스테인 수치가 낮아짐을 알았다. 실제로 칼슘섭취량의 증가가 호모시스테인 농도를 감소시킬 수 있을 지에 추가적인 연구가 수반되어야 하겠다.
Abstract
Background: Elevated plasma total homocysteine causes the risk of cardiovascular diseases. By reducing plasma total homocysteine may prevent cardiovascular diseases. Many studies showed that vitamin B12 and folic acid decrease homocysteine level when taken with calcium fortified drinking water. Our aim of this study was to demonstrate the association between plasma homocysteine concentrations and daily calcium intake. Methods: Among 636 adults aged 40-69 years who visited a health promotion center of a university hospital from May 2006 to April 2007, the study subjects were 567 who completed self-reported questionnaire. Self-reported calcium intake amount and their baseline health questionnaire were obtained. We measured height and weight by physical examination. Through blood test, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, plasma creatinine and homocysteine level were evaluated. Results: The mean daily calcium intake of entire subjects was 770.1 ± 266.3 mg. The mean plasma homocysteine concentration was 10.6 ± 4.3 μmol/L. The multiple regression analysis showed significant correlations between plasma homocysteine level and body mass index, plasma creatinine level and calcium intake. Plasma homocysteine level was inversely associated with dietary calcium intake. Conclusion: We found the calcium was inversely associated and homocysteine level an independent risk factor of cardiovascular diseases. However, further studies should be established to confirm if greater calcium intake may lower plasma homocysteine level.
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