한국 남성에서 낮은 HDL-콜레스테롤혈증 유병률 및 그 관련요인 추세: 1998년에서 2005년까지 3개의 국민건강영양조사를 자료를 이용하여
Trend of Prevalence of Low HDL-Cholesterol and Related Factors in Korean Men: Using 3 Korean National Health and Nutrition Examination Survey Data (1998-2005)
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연구배경: 낮은 high density lipoproteins (HDL)-콜레스테롤혈증은 허혈성심질환을 일으키는 주요한 위험인자 중 하나이다. 본 연구에서는 1998년, 2001년, 2005년의 국민건강영양조사 자료를 이용하여 같은 기준치를 적용했을 때 한국 남성에서 낮은 HDL-콜레스테롤혈증의 유병률 변화 양상 및 그와 관련된 요인들의 추세도 살펴보아 향후 예방 관리 대책을 모색하는데 기초 자료로 삼고자 하였다. 방법: 1998년, 2001년, 2005년에 시행된 3개의 국민건강영양조사 자료를 분석하였으며 검진자료가 있는 30세에서 79세 나이의 남성이 연구에 포함되었다. 낮은 HDL-콜레스테롤혈증의 기준은 National Cholesterol Education Program Adult Treatment Panel III에서 제시한 40 mg/dL 미만인 경우로 하였으며, 관련 요인은 다변량로지스틱 회귀분석을 이용하였다. 낮은 HDL-콜레스테롤혈증 및 관련 요인에 대해 시계열적으로 유병률 추세를 살펴보았다. 결과: 한국 남성에서 낮은 HDL-콜레스테롤혈증의 유병률은1998년 26.3%에서 2001년 38.8%, 2005년 45.9%로 지속적으로증가하고 있었다. 유의한 관련 요인으로 나타난 흡연, 비음주,신체적 비활동, 비만, 고중성지방혈증의 시계열적 유병률 변화를 볼 때, 흡연 및 신체적 비활동, 고중성지방혈증의 빈도는2001년도에 비해 2005년도에 감소하고 있는 반면, 비음주와비만은 지속적으로 증가하고 있었다. 결론: 낮은 HDL-콜레스테롤혈증의 유병률은 점점 증가하여관리 대책이 필요한 시점이다. 다른 요인들에 비해 비음주와비만은 지속적으로 증가하고 있어 낮은 HDL-콜레스테롤혈증 유병률 증가에 비음주와 비만의 영향이 크다고 보여지며이의 예방을 위해서는 비만의 관리가 중요하다고 여겨진다.
Abstract
Background: Low high density lipoprotein-cholesterol (HDL-C) is one of the major risk factors for coronary heart disease. Using data from the Korean National Health and Nutrition Examination Survey (KNHANES), we assessed trend of the prevalence of low HDL-C and the factors which are associated with low HDL-C in Korean men. Methods: We analyzed three serial KNHANES data which were conducted in year 1998, 2001, and 2005. Among all survey participants, we included men aged 30-79 years with laboratory data. Low HDL-C was defined by serum HDL-C < 40mg⁄dL. We used multiple logistic regression analysis to assess the association between low HDL-C and related factors. We investigated trend of the prevalence of low HDL-C and associated factors among Korean men. Results: The prevalence of low HDL-C in Korean men was increasing from 26.3% (1998) to 38.8% (2001) and 45.9%(2005). Low HDL-C was associated with non-alcohol drinker, current smoking, sedentary physical activity, obesity and hypertriglyceridemia. The prevalence of current smoking decreased linearly. The prevalence of sedentary physical activity and hypertriglyceridemia increased from year 1998 to year 2001, but decreased from year 2001 to year 2005. However, the prevalence of non-alcohol drinker and obesity increased continuously. The patterns of the increasing prevalence of low HDL-C were compatible to the increasing prevalence of obesity according to age in Korean men. Conclusion: From year 1998 to year 2005, the prevalence of low HDL-C in Korean men has increased. Obesity and nonalcohol drinking might be contributing factors of increasing prevalence of low HDL-C in Korean men. Management of obesity is needed to prevent increasing the prevalence of low HDL-C among Korean men.
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