Association between Body Mass Index, Waist Circumference and Prevalence of Microalbuminuria in Korean Adults of Age 30 Years and Older without Diabetes, Hypertension, Renal Failure, or Overt Proteinuria: The 2013 Korean National Health and Nutrition Examination Survey
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Microalbuminuria and obesity markers are known risk factors for cardiovascular or renal disease. This study aimed to evaluate the prevalence of microalbuminuria according to body mass index (BMI) and abdominal obesity criteria. Methods: The study subjects included 3,979 individuals aged 30 years or older who did not have diabetes, hypertension, renal failure, or overt proteinuria, from among those who participated in The Korean National Health and Nutrition Examination Survey in 2013, a cross-sectional, nationally representative, stratified survey. Microalbuminuria was defined as a urinary albumin to creatinine ratio of 30 to 300 mg/g. BMI and waist circumference were classified according to the Asia-Pacific criteria. Results: The prevalence of microalbuminuria was found to be 5.1%. In the normoalbuminuria group, 3.4%, 41.7%, 24%, 27.6%, and 3.2% of participants were included in the underweight, normal, overweight, obesity 1, and obesity 2 groups, respectively. These percentages in the microalbuminuria group were 7.1%, 34.5%, 19.2%, 28.6%, and 10.6%, respectively (P<0.001). The waist circumference in men was 21.4% in the normoalbuminuria group and 36.5% in the microalbuminuria group (P=0.004). Logistic regression analyses were performed to evaluate the relationship between the presence of microalbuminuria and BMI or waist circumference groups. The risk of microalbuminuria was significant only in the underweight group (odds ratio, 13.22; 95% confidence interval, 2.55–68.63; P=0.002) after adjusting for confounding factors, abdominal obesity was not significantly associated with microalbuminuria. Conclusion: The prevalence of microalbuminuria in a general population in Korea was associated with underweight in men and was not associated with waist circumference in either men or women.
Abstract
Background: Microalbuminuria and obesity markers are known risk factors for cardiovascular or renal disease. This study aimed to evaluate the prevalence of microalbuminuria according to body mass index (BMI) and abdominal obesity criteria. Methods: The study subjects included 3,979 individuals aged 30 years or older who did not have diabetes, hypertension, renal failure, or overt proteinuria, from among those who participated in The Korean National Health and Nutrition Examination Survey in 2013, a cross-sectional, nationally representative, stratified survey. Microalbuminuria was defined as a urinary albumin to creatinine ratio of 30 to 300 mg/g. BMI and waist circumference were classified according to the Asia-Pacific criteria. Results: The prevalence of microalbuminuria was found to be 5.1%. In the normoalbuminuria group, 3.4%, 41.7%, 24%, 27.6%, and 3.2% of participants were included in the underweight, normal, overweight, obesity 1, and obesity 2 groups, respectively. These percentages in the microalbuminuria group were 7.1%, 34.5%, 19.2%, 28.6%, and 10.6%, respectively (P<0.001). The waist circumference in men was 21.4% in the normoalbuminuria group and 36.5% in the microalbuminuria group (P=0.004). Logistic regression analyses were performed to evaluate the relationship between the presence of microalbuminuria and BMI or waist circumference groups. The risk of microalbuminuria was significant only in the underweight group (odds ratio, 13.22; 95% confidence interval, 2.55–68.63; P=0.002) after adjusting for confounding factors, abdominal obesity was not significantly associated with microalbuminuria. Conclusion: The prevalence of microalbuminuria in a general population in Korea was associated with underweight in men and was not associated with waist circumference in either men or women.
참고문헌 (31)
- Estacio RO, "Relation of reduction in urinary albumin excretion to ten-year cardiovascular mortality in patients with type 2 diabetes and systemic hypertension", Am J Cardiol, 109, pp.1743~1748 (2012)
- Thoenes M, "Abdominal obesity is associated with microalbuminuria and an elevated cardiovascular risk profile in patients with hypertension", Vasc Health Risk Manag, 5, pp.577~585 (2009)
- Jones CA, "Microalbuminuria in the US population: third National Health and Nutrition Examination Survey", Am J Kidney Dis, 39, pp.445~459 (2002)
- Adachi H, "Microalbuminuria is an independent prognostic information for cardiovascular disease", Atherosclerosis, 237, pp.106~107 (2014)
- De Jong PE, "From secondary to primary prevention of progressive renal disease: the case for screening for albuminuria", Kidney Int, 66, pp.2109~2118 (2004)
- Hillege HL, "Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population", Circulation, 106, pp.1777~1782 (2002)
- Tamba S, "Relationship between visceral fat accumulation and urinary albumin-creatinine ratio in middle-aged Japanese men", Atherosclerosis, 211, pp.601~605 (2010)
- 김원술, "일개 종합검진 남성 수진자에서 미세알부민뇨의 위험인자로서의 복부비만", Korean Journal of Health Promotion, 6(2), pp.114~119 (2006), 대한임상건강증진학회
- Chang Y, "Abdominal obesity, systolic blood pressure, and microalbuminuria in normotensive and euglycemic Korean men", Int J Obes (Lond), 30, pp.800~804 (2006)
- Pinto-Sietsma SJ, "A central body fat distribution is related to renal function impairment, even in lean subjects", Am J Kidney Dis, 41, pp.733~741 (2003)
- Choi KH, "Prevalence and clinical characteristics of microalbuminuria in Koreans", Korean J Med, 70, pp.605~607 (2006)
- 김은란, "한국인에서 미세단백뇨의 유병률 및 임상적 특성", 대한내과학회지, 70(6), pp.617~626 (2006), 대한내과학회
- 이현영, "유지 혈액투석 환자에서 영양실조-염증 점수와 동맥경화의 연관성", 대한내과학회지, 71(6), pp.635~645 (2006), 대한내과학회
- Jang CM, "The association between underweight and the development of albuminuria is different between sexes in relatively healthy Korean subjects", Nephrol Dial Transplant, 29, pp.2106~2113 (2014)
- Sato Y, "Ushaped association between body mass index and proteinuria in a large Japanese general population sample", Clin Exp Nephrol, 18, pp.75~86 (2014)
- Golledge J, "Body mass index is inversely associated with mortality in patients with peripheral vascular disease", Atherosclerosis, 229, pp.549~555 (2013)
- The 2013 Korea National Health and Nutrition Examination Survey, "Ministry of Health and Welfare", Ministry of Health and Welfare, ~ (2013)
- The Asia-Pacific perspective: redefining obesity and its treatment, "Bassett J", Health Communications Australia, ~ (2000)
- Levey AS, "A more accurate method to estimate glomerular filtration rate from serum creatinine:a new prediction equation. Modification of Diet in Renal Disease Study Group", Ann Intern Med, 130, pp.461~470 (1999)
- Park H, "Cut-off values of waist circumference for abdominal obesity among Koreans", J Korean Med Assoc, 48, pp.1165~1172 (2005)
- Cirillo M, "Low muscular mass and overestimation of microalbuminuria by urinary albumin", creatinine ratio, 2006, pp.47, 56~61
- Brenner BM, "Congenital oligonephropathy and the etiology of adult hypertension and progressive renal injury", Am J Kidney Dis, 23, pp.171~175 (1994)
- Luyckx VA, "Low birth weight, nephron number, and kidney disease", Kidney Int Suppl, 97, pp.S68~S77 (2005)
- Menon V, "Relationship between C-reactive protein, albumin, and cardiovascular disease in patients with chronic kidney disease", Am J Kidney Dis, 42, pp.44~52 (2003)
- Bashir S, "Role of C-reactive protein as a marker for microalbuminuria in type 2 diabetics", J Ayub Med Coll Abbottabad, 26, pp.32~34 (2014)
- Sharma S, "Microalbuminuria and C-reactive protein as a predictor of coronary artery disease in patients of acute chest pain", J Cardiovasc Dis Res, 4, pp.37~39 (2013)
- Kaizu Y, "Association between inflammatory mediators and muscle mass in long-term hemodialysis patients", Am J Kidney Dis, 42, pp.295~302 (2003)
- Abramson JL, "Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults", Arch Intern Med, 162, pp.1286~1292 (2002)
- Yamada M, "Age-dependent changes in skeletal muscle mass and visceral fat area in Japanese adults from 40 to 79 years-of-age", Geriatr Gerontol Int, 14(Suppl 1), pp.8~14 (2014)
- Park JH, "Female hormone and obesity", Korean J Health Promot Dis Prev, 4, pp.S208~S213 (2004)
- Matsushita Y, "Adiponectin and visceral fat associate with cardiovascular risk factors", Obesity (Silver Spring), 22, pp.287~291 (2014)