Associations between Anemia and Glomerular Filtration Rate and Albuminuria in Korean Adults by Metabolic Syndrome Status: Analysis of KNHNES V-3 Data
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초록
The present study was conducted to explore relationships between anemia and estimated glomerular filtration rate (eGFR) and urine microalbumin/creatinine ratio (uACR) in Korean adults with or without metabolic syndrome (MetS). The data of 4,943 adults aged ≥20 years who participated in KNHNES V-3 (2012) were analyzed. In the non-MetS group, the odds ratio (OR) for anemia of those with a decreased eGFR {eGFR＜60 mL/min/1.73 m2, 3.85 (95% confidence interval [CI], 2.03∼ 7.30)} was significant as was the OR of those with decreased eGFR plus elevated uACR (eGFR＜60 mL/min/1.73 m2 and uACR≥30 mg/g, 5.81 [95% CI, 2.60∼13.02]). In the MetS group, ORs for anemia for those with an elevated uACR (2.18 [95% CI, 1.11∼4.27]), a decreased eGFR (3.74 [95% CI, 1.11∼ 12.55]), or a decreased eGFR plus an elevated uACR (16.79 [95% CI, 5.93∼47.57]) were significant. In conclusion, in non-MetS, anemia was associated with a low eGFR, whereas in MetS, anemia was associated with a low eGFR and an elevated uACR. In addition, the OR for anemia was greatly increased when eGFR was diminished and uACR was elevated regardless of MetS and MetS status.
Abstract
The present study was conducted to explore relationships between anemia and estimated glomerular filtration rate (eGFR) and urine microalbumin/creatinine ratio (uACR) in Korean adults with or without metabolic syndrome (MetS). The data of 4,943 adults aged ≥20 years who participated in KNHNES V-3 (2012) were analyzed. In the non-MetS group, the odds ratio (OR) for anemia of those with a decreased eGFR {eGFR＜60 mL/min/1.73 m2, 3.85 (95% confidence interval [CI], 2.03∼ 7.30)} was significant as was the OR of those with decreased eGFR plus elevated uACR (eGFR＜60 mL/min/1.73 m2 and uACR≥30 mg/g, 5.81 [95% CI, 2.60∼13.02]). In the MetS group, ORs for anemia for those with an elevated uACR (2.18 [95% CI, 1.11∼4.27]), a decreased eGFR (3.74 [95% CI, 1.11∼ 12.55]), or a decreased eGFR plus an elevated uACR (16.79 [95% CI, 5.93∼47.57]) were significant. In conclusion, in non-MetS, anemia was associated with a low eGFR, whereas in MetS, anemia was associated with a low eGFR and an elevated uACR. In addition, the OR for anemia was greatly increased when eGFR was diminished and uACR was elevated regardless of MetS and MetS status.
참고문헌 (39)
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