The Relationship between Aortic Knob Width and Metabolic Syndrome
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Both aortic knob width and metabolic syndrome are suggested to be related to atherosclerosis andcardiovascular diseases. However, the association between aortic knob width and metabolic syndrome is unknown. This study aimed to explore this relationship. Methods: Participants were 3,705 Korean adults aged 18–79 years who visited the health promotion center of ageneral hospital. Data on chest radiography, physical measurements, medical and social history, and blood testswere collected. We defined metabolic syndrome according to the National Cholesterol Education Program AdultTreatment Panel III criteria. A single reviewer measured aortic knob width on chest radiography. Results: Aortic knob width was significantly correlated with age; body mass index; waist circumference; systolicand diastolic blood pressures; total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoproteincholesterol, fasting glucose, glycated hemoglobin, insulin, and uric acid levels; and homeostatic model assessmentof insulin resistance values. Aortic knob width significantly increased as the number of metabolic syndromecomponents increased. Moreover, metabolic syndrome component values tended to increase across thequartile groups of aortic knob width after adjusting for age, exercise, smoking status, and alcohol use. Through receiveroperating characteristic curve analysis, we determined the clinically useful cutoff value for aortic knob widthto be 30.47 mm in premenopausal women. Conclusion: Aortic knob width was found to be significantly related to metabolic syndrome and its individual components.
Abstract
Background: Both aortic knob width and metabolic syndrome are suggested to be related to atherosclerosis andcardiovascular diseases. However, the association between aortic knob width and metabolic syndrome is unknown. This study aimed to explore this relationship. Methods: Participants were 3,705 Korean adults aged 18–79 years who visited the health promotion center of ageneral hospital. Data on chest radiography, physical measurements, medical and social history, and blood testswere collected. We defined metabolic syndrome according to the National Cholesterol Education Program AdultTreatment Panel III criteria. A single reviewer measured aortic knob width on chest radiography. Results: Aortic knob width was significantly correlated with age; body mass index; waist circumference; systolicand diastolic blood pressures; total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoproteincholesterol, fasting glucose, glycated hemoglobin, insulin, and uric acid levels; and homeostatic model assessmentof insulin resistance values. Aortic knob width significantly increased as the number of metabolic syndromecomponents increased. Moreover, metabolic syndrome component values tended to increase across thequartile groups of aortic knob width after adjusting for age, exercise, smoking status, and alcohol use. Through receiveroperating characteristic curve analysis, we determined the clinically useful cutoff value for aortic knob widthto be 30.47 mm in premenopausal women. Conclusion: Aortic knob width was found to be significantly related to metabolic syndrome and its individual components.
참고문헌 (25)
- Erbel R, "2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC)", Eur Heart J, 35, pp.2873~2926 (2014)[DOI]
- Erdem K, "Predictive value of aortic knob width for postoperative atrial fibrillation in coronary artery bypass surgery", Anadolu Kardiyol Derg, 14, pp.68~72 (2014)
- Rayner BL, "The chest radiograph: a useful investigation in the evaluation of hypertensive patients", Am J Hypertens, 17, pp.507~510 (2004)[DOI]
- Yun KH, "Clinical significance of aortic knob width and calcification in unstable angina", Circ J, 70, pp.1280~1283 (2006)[DOI]
- Anyanwu GE, "Transverse aortic arch diameters and relationship with heart size of Nigerians within the South East", Biomed Res, 18, pp.115~118 (2007)
- US Preventive Services Task Force, "Statin use for the primary prevention of cardiovascular disease in adults: US Preventive Services Task Force recommendation statement", JAMA, 316, pp.1997~2007 (2016)[DOI]
- Isomaa B, "Cardiovascular morbidity and mortality associated with the metabolic syndrome", Diabetes Care, 24, pp.683~689 (2001)[DOI]
- Korkmaz L, "Relationship of aortic knob width with cardio-ankle vascular stiffness index and its value in diagnosis of subclinical atherosclerosis in hypertensive patients: a study on diagnostic accuracy", Anadolu Kardiyol Derg, 12, pp.102~106 (2012)
- Erkan H, "Relation between carotid intima-media thickness and aortic knob width in patients with essential hypertension", Blood Press Monit, 16, pp.282~284 (2011)[DOI]
- Levey AS, "A new equation to estimate glomerular filtration rate", Ann Intern Med, 150, pp.604~612 (2009)[DOI]
- Matthews DR, "Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28, pp.412~419 (1985)[DOI]
- National Cholesterol Education Program (NCEP) Expert Panel on Detection, "Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report", Circulation, 106, pp.3143~3421 (2002)
- Lee SY, "Appropriate waist circumference cutoff points for central obesity in Korean adults", Diabetes Res Clin Pract, 75, pp.72~80 (2007)[DOI]
- Grundy SM, "Diagnosis and management of the metabolic syndrome: an American Heart Association", National Heart, Lung, and Blood Institute Scientific Statement, 2005, pp.112, 2735~2752
- Higaki T, "Usefulness of aortic knob width on chest radiography to predict central hemodynamics in patients with known or suspected coronary artery disease", Clin Exp Hypertens, 37, pp.440~444 (2015)[DOI]
- Torun E, "Clinical implications of chest X-ray parameters in evaluating patients with cardiac dyspnea", Eurasian J Med, 40, pp.133~136 (2008)
- Hanley JA, "Encyclopedia of biostatistics" (2005), John Wiley & Sons
- Hanley JA, "The meaning and use of the area under a receiver operating characteristic (ROC) curve", Radiology, 143, pp.29~36 (1982)[DOI]
- Milewicz DM, "Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction", Annu Rev Genomics Hum Genet, 9, pp.283~302 (2008)[DOI]
- Ray A, "Aortic knob diameter in chest X-ray and its relation with age, heart diameter and transverse diameter of thorax in a population of Bankura District of West Bengal, India: a cross sectional study", J Evol Med Dent Sci, 3, pp.8595~8600 (2014)
- Hiratzka LF, "2010 ACCF", AHA, ACR, pp.ASA, SCA[DOI]
- Safar ME, "Metabolic syndrome and age-related progression of aortic stiffness", J Am Coll Cardiol, 47, pp.72~75 (2006)[DOI]
- Shankar N, "Anatomical variations of the aortic knob in chest radiographs", Eur J Anat, 14, pp.25~30 (2010)
- Afsar B, "The relationship between aortic knob width and various demographic, clinical, and laboratory parameters in stable hemodialysis patients", Saudi J Kidney Dis Transpl, 25, pp.1178~1185 (2014)[DOI]
- Georgiopoulos G, "Metabolic syndrome, independent of its components, affects adversely cardiovascular morbidity in essential hypertensives", Atherosclerosis, 244, pp.66~72 (2016)[DOI]