The Association between Obesity Phenotypes and Early Renal Function Decline in Adults without Hypertension, Dyslipidemia, and Diabetes
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Background: The prevalence of chronic kidney disease is increasing worldwide. Several studies have suggested that obesity is associated with early renal dysfunction. However, little is known about the relationship between obe-sity phenotypes and early renal function decline. Therefore, this study aimed to identify the relationship between obesity phenotypes and early renal function decline in adults without hypertension, dyslipidemia, and diabetes.Methods: We conducted a cross-sectional analysis of clinical and anthropometric data from 1,219 patients who un-derwent a routine health checkup in 2014. We excluded adults with cardiovascular disease, renal disease, diabetes, hypertension, dyslipidemia, or low glomerular filtration rate (<60 mL/min/1.73 m2). Renal function was deter-mined according to the estimated glomerular filtration rate calculated using the Chronic Kidney Disease Epidemi-ology Collaboration creatinine-cystatin C equation.Results: Age, sex, body mass index, waist circumference, triglyceride, low-density lipoprotein, and fasting glucose had an association with the estimated glomerular filtration rate. After adjusting for age, sex, smoking status, and al-cohol intake, the odds ratios of the metabolically abnormal normal weight and metabolically abnormal obese phe-notypes for the presence of low estimated glomerular filtration rates were 1.807 (95% confidence interval, 1.009–3.236) and 1.834 (95% confidence interval, 1.162–2.895), compared with the metabolically healthy normal weight phenotype. However, the metabolically healthy obese phenotype did not show a significant association with early renal function decline.Conclusion: In this cross-sectional study, we confirmed the association between the metabolically abnormal nor-mal weight and metabolically abnormal obese phenotypes and early kidney function decline in adults without hy-pertension, dyslipidemia, and diabetes.
Abstract
Background: The prevalence of chronic kidney disease is increasing worldwide. Several studies have suggested that obesity is associated with early renal dysfunction. However, little is known about the relationship between obe-sity phenotypes and early renal function decline. Therefore, this study aimed to identify the relationship between obesity phenotypes and early renal function decline in adults without hypertension, dyslipidemia, and diabetes.Methods: We conducted a cross-sectional analysis of clinical and anthropometric data from 1,219 patients who un-derwent a routine health checkup in 2014. We excluded adults with cardiovascular disease, renal disease, diabetes, hypertension, dyslipidemia, or low glomerular filtration rate (<60 mL/min/1.73 m2). Renal function was deter-mined according to the estimated glomerular filtration rate calculated using the Chronic Kidney Disease Epidemi-ology Collaboration creatinine-cystatin C equation.Results: Age, sex, body mass index, waist circumference, triglyceride, low-density lipoprotein, and fasting glucose had an association with the estimated glomerular filtration rate. After adjusting for age, sex, smoking status, and al-cohol intake, the odds ratios of the metabolically abnormal normal weight and metabolically abnormal obese phe-notypes for the presence of low estimated glomerular filtration rates were 1.807 (95% confidence interval, 1.009–3.236) and 1.834 (95% confidence interval, 1.162–2.895), compared with the metabolically healthy normal weight phenotype. However, the metabolically healthy obese phenotype did not show a significant association with early renal function decline.Conclusion: In this cross-sectional study, we confirmed the association between the metabolically abnormal nor-mal weight and metabolically abnormal obese phenotypes and early kidney function decline in adults without hy-pertension, dyslipidemia, and diabetes.
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