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바이러스 질병 예방을 위한 식물 경구 백신 연구 동향

Recent Studies of Edible Plant Vaccine for Prophylactic Medicine against Virus-mediated Diseases

김용환|박종석|김종범|김형국|하선화|한범수|조강진
한국식물생명공학회 (Korean Society for Plant Biotechnology)|2004.06|Journal of Plant Biotechnology|제31권 제2호|pp. 151-161

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참고문헌

주제분류농학

초록

Abstract

Transgenic plants have been studied as delivery system for edible vaccine against various diseases. Edible plant vaccines have several potential advantages as follows: an inexpensive source of antigen, easy administration, reduced need for medical personnel, economical to mass produce and easy transport, heat-stable vaccine without refrigerator, generation of systemic and mucosal immunity and safe antigen without fetal animal-virus contaminants. The amount of recombinant antigens in transgenic plants ranged from 0.002 to 0.8% in total soluble protein, depending on promoters for the expression of interested genes and plants to be used for transformation. Throughout the last decade, edible plant vaccine made notable progresses that protect from challenges against virus or bacteria. However edible plant vaccines have still problems that could be solved. First, the strong promoter or inducible promoter or strategy of protein targeting could be solved to improve the low expression of antigens in transgenic plants. Second, the transformation technique of target plant should be developed to be able to eat uncooked. Third, marker-free vector could be constructed to be more safety. In this review we describe advances of edible plant vaccines, focusing on the yields depending on plants/promoters employed and the results of animal/clinical trials, and consider further research for the development of a new plant-derived vaccine.

참고문헌 (70)

  1. Arntzen CJ, "Pharmaceutical foodstuffs-oral immunization with transgenic plants", 4, pp.502~503 (1998)
  2. Avendano P, "Costs associated with office visits for diarrhea in infants and toddlers", pp.897~902 (1993)
  3. Barrett T, "Rinderpest: the disease and its impact on humans and animals", 53, pp.89~110 (1999)
  4. Biemelt S,, "Production of human papillomavirus type 16 virus-like particles in transgenic plants", 77, pp.9211~9220 (2003)
  5. Bouche FB, "Neutralising immunogenicity of a polyepitope antigen expressed in a transgenic food plant a novel antigen to protect against measles", 21, pp.2065~2072 (2003)
  6. Carrillo C,, "Protective immune response to foot-and-mouth disease virus with VP1 expressed in transgenic plants", 72, pp.1688~1690 (1998)
  7. Carrillo C,, "Induction of a virus-specific antibody response to foot and mouth disease virus using the structural protein VP1 expressed in transgenic potato plants", 14, pp.49~57 (2001)
  8. Castanon S,, "The effect of the promoter on expression of VP 60 gene from rabbit hemorrhagic disease virus in potato plants", 162, pp.87~95 (2002)
  9. Castanon S,, "Immunization with potato plants expressing VP60 protein protects against rabbit hemorrhagic disease virus", 73, pp.4452~4455 (1999)
  10. Chikwamba R,, "A functional antigen in a practical crop: LT-B producing maize protects mice against Escherichia coli heat labile enterotoxin (LT) and cholera toxin (CT", 11, pp.479~493 (2002)
  11. Davies G, "Foot and mouth disease", 73, pp.195~199 (2002)
  12. Fotisch K, "N- and O-linked oligosaccharides of allergenic glycoproteins", 18, pp.373~390 (2001)
  13. Gao Y,, "Oral immunization of animals with transgenic cherry tomatillo expressing HBsAg.", 9, pp.996~1002 (2003)
  14. Gil F,, "High-yield expression of a viral peptide vaccine in transgenic plants", 488, pp.13~17 (2001)
  15. Gomez N, "Expression of immunogenic glycoprotein S polypeptides from transmissible gastroenteritis coronavirus in transgenic plants", 249, pp.352~358 (1998)
  16. Gomez N,, "Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus", 145, pp.1725~1732 (2000)
  17. Hajdukiewicz PT, "Multiple pathways for Cre", lox-mediated recombination in plastids, 2001, pp.27, 161~170
  18. Haq TA, "Oral immunization with a recombinant bacterial antigen produced in transgenic plants", 268, pp.714~715 (1995)
  19. Hein MB, "Expression of cholera toxin subunits in plants", 792, pp.50~56 (1996)
  20. Huang Z,, "Plant-derived measles virus hemagglutinin protein induces neutralizing antibodies in mice", 19, pp.2163~2171 (2001)
  21. Jackson AC, "Update on rabies", 15, pp.327~331 (2002)
  22. Kao JH, "Global control of hepatitis B virus infection", 2, pp.395~403 (2002)
  23. Kapikian AZ,, "Norwalk group of viruses", pp.783~810 (1996)
  24. Kapusta J,, "A plant-derived edible vaccine against hepatitis B virus", 13, pp.1796~1799 (1999)
  25. Khandelwal A, "Expression of hemagglutinin protein of rinderpest virus in transgenic tobacco and immunogenicity of plant-derived protein in a mouse model", 308, pp.207~215 (2003)
  26. Kim HS, "Introduction of hog cholera virus gene into potato plants by Agrobacterium- mediated transformation and the analysis of its expression", 4, pp.155~161 (2002)
  27. Kong Q, "Oral immunization with hepatitis B surface antigen expressed in transgenic plants", 98, pp.11539~11544 (2001)
  28. Lee YS, "Development of transgenic carrot oral vaccine to project against diarrhea of piglets", 29, pp.287~293 (2002)
  29. Lerouge P,, "N-glycosylation of recombinant pharmaceutical glycoproteins produced in transgenic plants: towards an humanisation of plant N-glycans", 1, pp.347~354 (2000)
  30. Lerouge P,, "N-glycoprotein biosynthesis in plants: recent developments and future trends", 38, pp.31~48 (1998)
  31. Liu SJ, "A new viral disease in rabbits", 16, pp.253~255 (1984)
  32. Loeffler F, "Summarischer bericht", uber der ergebnisse der untersuchungen zur erforschung der maul-und klauenseuche, 1897, pp.22, 257~259
  33. Ma Y,, "Expression of ORF2 partial gene of hepatitis E virus in tomatoes and immunoactivity of expression products", 9, pp.2211~2215 (2003)
  34. Mackie PL, "The classification of viruses infecting the respiratory tract", 4, pp.84~90 (2003)
  35. Markowitz LE, "Duration of live measles vaccine-induced immunity", 9, pp.101~110 (1990)
  36. Marquet-Blouin E,, "Neutralizing immunogenicity of transgenic carrot (Daucus carota L.)-derived measles virus hemagglutinin", 51, pp.459~469 (2003)
  37. Martin-Alonso JM,, "Oral immunization using tuber extracts from transgenic potato plants expressing rabbit hemorrhagic disease virus capsid protein", 12, pp.127~130 (2003)
  38. Mason HS, "Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice", 93, pp.5335~5340 (1996)
  39. Mason HS, "Expression of hepatitis B surface antigen in transgenic plants", 89, pp.11745~11749 (1992)
  40. Mason PW, "Molecular basis of pathogenesis of FMDV", 91, pp.9~32 (2003)
  41. Matsumura T, "Production of immunogenic VP6 protein of bovine group A rotavirus in transgenic potato plants", 147, pp.1263~1270 (2002)
  42. Modelska A,, "Immunization against rabies with plant-derived antigen", 95, pp.2481~2485 (1998)
  43. Pan American Health Organization, "Global measles efforts.", 22, pp.5~ (2000)
  44. Parra F, "The amino terminal sequence of VP60 from rabbit hemorrhagic disease virus supports its putative subgenomic origin", 27, pp.219~228 (1993)
  45. Richter LJ, "Production of hepatitis B surface antigen in transgenic plants for oral immunization", 18, pp.1167~1171 (2000)
  46. Ribeiro RM, "Dynamics of hepatitis B virus infection", 4, pp.829~835 (2002)
  47. Sagi L,, "Genetic transformation of banana and plantain (Musa spp.) via particle bombardment", 13, pp.481~485 (1995)
  48. Sandhu JS,, "Oral immunization of mice with transgenic tomato fruit expressing respiratory syncytial virus-F protein induces a systemic immune response.", 9, pp.127~135 (2000)
  49. Sandhu JS,, "Enhanced expression of the humn respiratory syncytial virus-F gene in apple leaf protoplasts.", 18, pp.394~397 (1999)
  50. plants, , 2003, 651~658
  51. Smith ML, "Structural characterization of plant-derived hepatitis B surface antigen employed in oral immunization studies", 21, pp.4011~4021 (2003)
  52. Sojikul P, "A plant signal peptide-hepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells", 100, pp.2209~2214 (2003)
  53. Tacket CO, "Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato", 4, pp.607~609 (1998)
  54. Tacket CO, "Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes", pp.302~305 (2000)
  55. Taraporewala ZF, "Nonstructural proteins involved in genome packaging and replication of rotaviruses and other members of the Reoviridae", 101, pp.57~66 (2004)
  56. Yang YF, "Immunogenicity of transgenic plant-derived hepatitis B surface antigen", 92, pp.3358~3361 (1995)
  57. Tregoning JS,, "Expression of tetanus toxin Fragment C in tobacco chloroplasts", 31, pp.1174~1179 (2003)
  58. Tuboly T,, "Immunogenicity of porcine transmissible gastroenteritis virus spike protein expressed in plants", 18, pp.2023~2028 (2000)
  59. Turpen TH,, "Malarial epitopes expressed on the surface of recombinant tobacco mosaic virus", 13, pp.53~57 (1995)
  60. Wang XG, "Purified cholera toxin B subunit from transgenic tobacco plants possesses authentic antigenicity", 72, pp.490~494 (2001)
  61. Warzecha H, "Oral immunogenicity of human papillomavirus-like particles expressed in potato", 77, pp.8702~8711 (2003)
  62. Webster DE,, "Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine.", 76, pp.7910~7912 (2002)
  63. WHO, "Supplementary information on vaccine safety" (2000)
  64. Wigdorovitz A,, "Induction of a protective antibody response to foot and mouth disease virus in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viral structural protein VP1", 255, pp.347~353 (1999)
  65. Woldehiwet Z, "Rabies: recent developments", 73, pp.17~25 (2002)
  66. Wu YZ,, "Oral immunization with rotavirus VP7 expressed in transgenic potatoes induced high titers of mucosal neutralizing IgA", 313, pp.337~342 (2003)
  67. Yusibov V,, "Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine", 20, pp.3155~3164 (2002)
  68. Yusibov V,, "Antigens produced in plants by infection with chimeric plant viruses immunize against rabies virus and HIV-1.", 94, pp.5784~5788 (1997)
  69. Zhou JY,, "Expression of immunogenic S1 glycoprotein of infectious bronchitis virus in transgenic potatoes.", 77, pp.9090~9093 (2003)
  70. Zur Hausen H, "Papillomaviruses and cancer: from basic studies to clinical application", 2, pp.342~350 (2002)

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