본문 바로가기
KERD
논문KCI 등재

어류 경구백신 현황과 전망

Edible vaccine for aquacultured fish: present and prospect

김미나|박주영|차재호|정화지|박은준
한국식물생명공학회 (Korean Society for Plant Biotechnology)|2010.09|Journal of Plant Biotechnology|제37권 제3호|pp. 269-274

2

조회

0

다운로드

2

인용

0

참고문헌

주제분류농학

초록

As the capture fishing industry has declined, the aquaculture industry has become an important source of seafood. With this tendency all fish farming will be performed by large-scale farms where the fish are cultivated in much high density and as a result the incidence of infectious diseases increases. Therefore, vaccination has become an increasingly important part of aquaculture as a cost effective method of controlling various diseases. The early fish vaccines were the formalin inactivated bacteria or virus cultures,which were administered by either immersion or injection. Recombinant DNA biotechnology allowed us to develop orally administrated DNA and ecombinant vaccines. In terms of the manufacturing process and cost,Lemna and Spirodela is the most efficient and reliable plant expression system for the production of edible vaccine.

Abstract

As the capture fishing industry has declined, the aquaculture industry has become an important source of seafood. With this tendency all fish farming will be performed by large-scale farms where the fish are cultivated in much high density and as a result the incidence of infectious diseases increases. Therefore, vaccination has become an increasingly important part of aquaculture as a cost effective method of controlling various diseases. The early fish vaccines were the formalin inactivated bacteria or virus cultures,which were administered by either immersion or injection. Recombinant DNA biotechnology allowed us to develop orally administrated DNA and ecombinant vaccines. In terms of the manufacturing process and cost,Lemna and Spirodela is the most efficient and reliable plant expression system for the production of edible vaccine.

참고문헌 (41)

  1. Allnutt FC, "Antigenicity of infectious pancreatic necrosis virus VP2 subviral particles expressed in yeast", Vaccine, 25, pp.4880~4888 (2007)
  2. Aviezer D, "A plant-derived recombinant human glucocerebrosidase enzyme-a preclinical and phase I investigation", PLoS One, 4(3), pp.e4792~ (2009)
  3. Caipang CMA, "Immunogenicity, retention and protective effects of the protein derivatives of formalininactivated red seabream iridovirus (RSIV) vaccine in red seabream, Pagrus major", Fish Shellfish Immunol, 20, pp.596~609 (2006)
  4. Caipang CMA, "Genetic vac cines protect red seabream, Pagrus major, upon challenge with red seabream iridovirus (RSIV)", Fish Shellfish Immunol, 21, pp.130~138 (2006)
  5. Chen Y, "Construction of a recombinant plasmid containing multi-copy CpG motifs and its effects on the innate immune responses of aquatic animals", Fish Shellfish Immunol, 23, pp.589~600 (2007)
  6. Davoodi-Semiromi A, "Chloroplastderived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery", Plant Biotechnol J, 8, pp.223~242 (2010)
  7. Floss DM, "Production of vaccines and therapeutic antibodies for veterinary applications in transgenic plants:an overview", Transgenic Res, 16, pp.315~332 (2007)
  8. Floss DM, "Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application", Trends Biotechnol, 28, pp.37~45 (2010)
  9. Frutos R, "Pharmaceutical proteins in plants. A strategic genetic engineering approach for the production of tuberculosis antigens", Ann N Y Acad Sci, 1149, pp.275~280 (2008)
  10. Fu LL, "Oral vaccination with envelope protein VP28 against white spot syndrome virus in Procambarus clarkii using Bacillus subtilis as delivery vehicles", Lett Appl Microbiol, 46, pp.581~586 (2008)
  11. de las Heras AI, "Immunogenic and protective effects of an oral DNA vaccine against infectious pancreatic necrosis virus in fish", Fish Shellfish Immunol, 28, pp.562~570 (2010)
  12. Jha RK, "Protection of Procambarus clarkii against white spot syndrome virus using recombinant oral vaccine expressed in Pichia pastoris", Fish Shellfish Immunol, 22, pp.295~307 (2007)
  13. Jorgensen JB, "CpG DNA induces protective antiviral immune responses in Atlantic salmon (Salmo salar L.)", J Virol, 77, pp.11471~11479 (2003)
  14. Komar C, "Understanding fish vaccination" (2004), AQUA Culture AsiaPacific Magazine
  15. Kurath G, "Biotechnology and DNA vaccines for aquatic animals", Rev Sci Tech, 27, pp.175~196 (2008)
  16. Lai H, "Monoclonal antibody produced in plants efficiently treats West Nile virus infection in mice", Proc Natl Acad Sci USA, 통권 : 107, pp.2419~2424 (2010)
  17. Lin JH, "An oral delivery system for recombinant subunit vaccine to fish", Dev Biol (Basel), 121, pp.175~180 (2005)
  18. Lombardi R, "High-level HIV-1 Nef transient expression in Nicotiana benthamiana using the P19 gene silencing suppressor protein of Artichoke Mottled Crinckle Virus", BMC Biotechnol, 9, pp.96~ (2009)
  19. Lorenzen N, "DNA vaccines for aquacultured fish", Rev Sci Tech, 24, pp.201~213 (2005)
  20. Martinez CA, "Exploring different strategies to express Dengue virus envelope protein in a plant system", Biotechnol Lett, 32, pp.867~875 (2010)
  21. Medrano G, "Efficient plant-based production of chicken interleukin-12 yields a strong immunostimulatory cytokine", J Interferon Cytokine Res, 30, pp.143~154 (2010)
  22. Ning JF, "Oral delivery of DNA vaccine encoding VP28 against white spot syndrome virus in crayfish by attenuated Salmonella typhimurium", Vaccine, 27, pp.1127~1135 (2009)
  23. Nochi T, "A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity", J Immunol, 183, pp.6538~6544 (2009)
  24. Pedersen GM, "Stimulation of type I IFN activity in Atlantic salmon (Salmo salar L.) leukocytes:synergistic effects of cationic proteins and CpG ODN", Fish Shellfish Immunol, 20, pp.503~518 (2006)
  25. Poobalane S, "Production and efficacy of an Aeromonas hydrophila recombinant S-layer protein vaccine for fish", Vaccine, 28, pp.3540~3547 (2010)
  26. Rajeshkumar S, "Oral delivery of DNA construct using chitosan nanoparticles to protect the shrimp from white spot syndrome virus (WSSV)", Fish Shellfish Immunol, 26, pp.429~437 (2008)
  27. Rival S, "Spirodela (duckweed) as an alternative production system for pharmaceuticals:a case study, aprotinin", Transgenic Res, 17, pp.503~513 (2008)
  28. Rodrigues AP, "Production and characterisation of alginate microparticles incorporating Aeromonas hydrophila designed for fish oral vaccination", Process Biochem, 41, pp.638~643 (2006)
  29. Romalde J, "Oral immunization using alginate microparticles as a useful strategy for booster vaccination against fish lactoccocosis", Aquaculture, 236, pp.119~129 (2004)
  30. Responsible use of vaccines and vaccination in fish production, "RUMA guidelines", Supported by the National Office of Animal Health (NOAH), ~ (2006)
  31. Shaaltiel Y, "Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system", Plant Biotechnol J, 5, pp.579~590 (2007)
  32. Sommerset I, "Protection against Atlantic halibut nodavirus in turbot is induced by recombinant capsid protein vaccination but not following DNA vaccination", Fish Shellfish Immunol, 18, pp.13~29 (2005)
  33. Stomp A-M, "The duckweeds:a valuable plant for biomanufacturing", Biotechnol Annu Rev, 11, pp.69~99 (2005)
  34. Stomp A-M, "Expression of biologically active polypeptide in duckweed. US patent 6815184", ~ (2004)
  35. Tian J, "Chitosan microspheres as candidate plasmid vaccine carrier for oral immunisation of Japanese flounder (Paralichthys livaceus)", Vet Immnol Immunopathol, 126, pp.220~229 (2008)
  36. Toranzo AE, "Present and future of aquaculture vaccines against fish bacterial diseases", Opinions Méditerranéennes, A, 86, pp.155~176 (2009)
  37. Vunsh R, "High expression of transgene protein in Spirodela", Plant Cell Rep, 26, pp.1511~1519 (2007)
  38. Wu H, "Toward the development of a plant-based vaccine against reovirus", Avian Dis, 53, pp.376~381 (2009)
  39. Yamamoto YT, "Genetic transformation of duckweed Lemna gibba and Lemna minor", In Vitro Cell Dev Biol, 37, pp.349~353 (2001)
  40. Zhu F, "Protection of Procambarus clarkii against white spot syndrome virus using inactivated WSSV", Fish Shellfish Immunol, 26, pp.685~690 (2009)
  41. 문진산, "어류 백신 품질관리 지침서. 국립수의과학검역원", ~ (2007)

관련 논문AI추천

국내 수산용 백신 개발 현황 및 발전 방향김명석, 김수진, 김태호, 조미영, 최혜승, 한현자한국수산과학회 · 한국수산과학회지2021 · 제54권 제4호세균성 질병 예방을 위한 식물 경구 백신 연구 동향 (총설)김용환, 김종범, 노경희, 박종석, 정영재, 조강진, 한범수한국식물생명공학회 · Journal of Plant Biotechnology2005 · 제32권 제4호Development and evaluation of an oral liposomal vaccine for the prevention of Edwardsiellosis in Anguilla japonica caused by Edwardsiella piscicidaAndre Kim, Byung-Chul Jeong, Chan-Il Park, Dong-Geun Lee, Jae Young Cha, Jun Cheul Ahn, Keun Woo Lee, Sang-Hyeon Lee, Won-Sik Woo, Young Jae Kim, Young Min Woo한국수산과학회 · Fisheries and Aquatic Sciences2025 · 제28권 제5호항원 생산 기반으로서의 식물 연구정혁, 김현순, 염정원, 전재흥한국식물생명공학회 · Journal of Plant Biotechnology2010 · 제37권 제3호바이러스 질병 예방을 위한 식물 경구 백신 연구 동향김용환, 김종범, 김형국, 박종석, 조강진, 하선화, 한범수한국식물생명공학회 · Journal of Plant Biotechnology2004 · 제31권 제2호The safety of live VHSV immersion vaccine at a temperature- controlled culture condition in juvenile olive flounder, Paralichthys olivaceus김수진, 오명주, 윤수영, 장요셉, Rahul Krishnan수산생명의학회 · 한국어병학회지2022 · 제35권 제2호

이 간행물의 다른 논문 (11건)

분자농업의 현황 및 전망김태금, 양문식pp. 243-249항원 생산 기반으로서의 식물 연구염정원, 전재흥, 김현순, 정혁pp. 250-261식물기반 치료용 항체생산박다영, 김현순, 전재홍, 소양강, 추영국, 고기성, 김영관pp. 262-268엽록체 형질전환 유래 분자 농업의 연구 동향이정희, 김석원, 정원중, 정화지, 민성란, 유장렬pp. 275-282경구백신의 효율적인 적용을 위한 면역 보조제 개발김주, 장용석, 서기원, 김새해pp. 283-291
원문 보기