Metoclopramide for Milk Production in Lactating Women: A Systematic Review and Meta-Analysis
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Background: Breastfeeding is recognized as the optimal form of nutrition for the physical and neurological devel-opment of infants and is considered the most significant way to prevent child mortality. This study aimed to assess the effectiveness of metoclopramide for enhancing milk production in lactating women.Methods: We searched the Cochrane Central Register of Controlled Trials and MEDLINE for randomized con-trolled trials comparing metoclopramide with a placebo, no treatment, or other galactagogue drugs. We included breastfeeding women with term or preterm infants.Results: We retrieved 164 records from our search of the electronic databases and 20 records from other sources. Eight trials involving 342 lactating women that used metoclopramide were included in this review after assessing the eligibility criteria. The meta-analysis of these trials revealed that metoclopramide did not increase the milk vol-ume of the intervention groups compared to that of the control groups. There was a significant increase in the se-rum concentrations of prolactin when the mothers were administered metoclopramide. No significant adverse events were reported.Conclusion: Metoclopramide did not improve milk production in lactating women. Therefore, we do not recom-mend using metoclopramide to increase milk production in lactating women.
Abstract
Background: Breastfeeding is recognized as the optimal form of nutrition for the physical and neurological devel-opment of infants and is considered the most significant way to prevent child mortality. This study aimed to assess the effectiveness of metoclopramide for enhancing milk production in lactating women.Methods: We searched the Cochrane Central Register of Controlled Trials and MEDLINE for randomized con-trolled trials comparing metoclopramide with a placebo, no treatment, or other galactagogue drugs. We included breastfeeding women with term or preterm infants.Results: We retrieved 164 records from our search of the electronic databases and 20 records from other sources. Eight trials involving 342 lactating women that used metoclopramide were included in this review after assessing the eligibility criteria. The meta-analysis of these trials revealed that metoclopramide did not increase the milk vol-ume of the intervention groups compared to that of the control groups. There was a significant increase in the se-rum concentrations of prolactin when the mothers were administered metoclopramide. No significant adverse events were reported.Conclusion: Metoclopramide did not improve milk production in lactating women. Therefore, we do not recom-mend using metoclopramide to increase milk production in lactating women.
참고문헌 (25)
- Bhandari N, "Mainstreaming nutrition into maternal and child health programmes: scaling up of exclusive breastfeeding", Matern Child Nutr, 4(Suppl 1), pp.5~23 (2008)
- World Health Organization, "Global strategy for infant and young child feeding", World Health Organization, ~ (2003)
- Amir LH, "Managing common breastfeeding problems in the community", BMJ, 348, pp.g2954~ (2014)
- Stuebe AM, "Enabling women to achieve their breastfeeding goals", Obstet Gynecol, 123, pp.643~652 (2014)
- Wagner EA, "Breastfeeding concerns at 3 and 7 days postpartum and feeding status at 2months", Pediatrics, 132, pp.e865~e875 (2013)
- Powers NG, "Slow weight gain and low milk supply in the breastfeeding dyad", Clin Perinatol, 26, pp.399~430 (1999)
- Amir LH, "Breastfeeding : managing ‘supply’ difficulties", Aust Fam Physician, 35, pp.686~689 (2006)
- Academy Of Breastfeeding Medicine Protocol Committee, "ABM Clinical Protocol #9: use of galactogogues in initiating or augmenting the rate of maternal milk secretion (first revision January 2011)", Breastfeed Med, 6, pp.41~49 (2011)
- Gabay MP, "Galactogogues : medications that induce lactation", J Hum Lact, 18, pp.274~279 (2002)
- Sousa PL, "Letter : Metoclopramide and breast-feeding", Br Med J, 1, pp.512~ (1975)
- Anderson PO, "The galactogogue bandwagon", J Hum Lact, 29, pp.7~10 (2013)
- Higgins JP, "The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials", BMJ, 343, pp.d5928~ (2011)
- Ehrenkranz RA, "Metoclopramide effect on faltering milk production by mothers of premature infants", Pediatrics, 78, pp.614~620 (1986)
- Toppare MF, "Metoclopramide for breast milk production", Nutr Res, 14, pp.1019~1029 (1994)
- Lewis PJ, "Controlled trial of metoclopramide in the initiation of breast feeding", Br J Clin Pharmacol, 9, pp.217~219 (1980)
- Osouli Tabrizi S, "The effect of metoclopramide on prolactin levels in breastfeeding mothers : a systematic review and meta-analysis", Int J Pediatr, 5, pp.5827~5838 (2017)
- de Gezelle H, "Metoclopramide and breast milk", Eur J Obstet Gynecol Reprod Biol, 15, pp.31~36 (1983)
- Fife S, "Metoclopramide to augment lactation, does it work?: a randomized trial", J Matern Fetal Neonatal Med, 24, pp.1317~1320 (2011)
- Guzman V, "Improvement of defective lactation by using oral metoclopramide", Acta Obstet Gynecol Scand, 58, pp.53~55 (1979)
- Hansen WF, "Metoclopramide effect on breastfeeding the preterm infant : a randomized trial", Obstet Gynecol, 105, pp.383~389 (2005)
- Ingram J, "Metoclopramide or domperidone for increasing maternal breast milk output:a randomised controlled trial", Arch Dis Child Fetal Neonatal Ed, 97, pp.F241~F245 (2012)
- Kauppila A, "Metoclopramide and breast feeding : efficacy and anterior pituitary responses of the mother and the child", Eur J Obstet Gynecol Reprod Biol, 19, pp.19~22 (1985)
- Sakha K, "Training for perfect breastfeeding or metoclopramide: which one can promote lactation in nursing mothers?", Breastfeed Med, 3, pp.120~123 (2008)
- Seema, "Relactation : an effective intervention to promote exclusive breastfeeding", J Trop Pediatr, 43, pp.213~216 (1997)
- Foong SC, "Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants", Cochrane Database Syst Rev, 5, pp.CD011505~ (2020)