Augmentation Index로 측정한 동맥 경직도와 흡연 여부와의 관련성
Smoking Status and Augmentation Index in Korean Male Subjects
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연구배경: 흡연은 심혈관 질환의 주요한 위험 인자이다. 동맥의 경직도는 심혈관 질환의 발생과 예후의 예측인자로 알려져 있으며, 파형증가지수(augmentation index, AIx)는 비침습적으로 측정이 가능한 동맥 경직도의 지표이다. 본 연구는 한국인 남성을 대상으로 AIx를 측정해 흡연 여부가 동맥 경직도에 미치는 영향을 알아보았다. 방법: 본 단면 조사 연구는 심혈관계 질환이 없는 남성 70명을 대상으로 하였다. 흡연 중인 남성 35명과 비흡연 남성 35명에서 AIx를 측정하여 두 군에서의 AIx의 차이를 Student't-test로 비교하였다. AIx에 영향을 미치는 인자인 연령, 신장, 맥박수와 평균동맥압(mean arterial pressure, MAP)을 보정해 흡연 여부가 독립적으로 AIx에 미치는 영향을 다중 회귀 분석으로 알아보았다. 결과: AIx는 흡연군에서 19.4±12.9%, 비흡연군에서 9.7±12.8%로 유의한 차이를 보였다(P＜0.05). 다중 회귀 분석 결과, 흡연 여부는 AIx에 영향을 주는 유의한 독립적인 변수였다(β=0.350, P＜0.001). 결론: 흡연은 심혈관 질환의 지표인 동맥 경직도의 증가와 관련이 있다.
Abstract
Smoking Status and Augmentation Index in Korean Male SubjectsEui Jeong Woo, M.D., Hong Soo Lee, M.D.†, Sang Hwa Lee, M.D., Kyung Won Shim, M.D., Sooa Kim, M.D., Young A Oh, M.D., Myoung Jin Lee, M.D. Background: Smoking is a major risk factor of cardiovascular morbidity and mortality. Arterial stiffness has been identified as an important determinant of cardiovascular risk. Augmentation index is an indicator of arterial stiffness, which can be quantified noninvasively. The goal of this study was to assess the effect of current smoking status on augmentation index (AIx) in Korean male subjects. Methods: A total of 70 males without clinical cardiovascular diseases were studied in this cross sectional study. AIx was measured in 35 current smokers and 35 nonsmokers by recording pressure waveforms using radial applanation tonometry in a SphygmoCor device. Results: Augmentation index was significantly higher in the current smokers (19.4±12.9% vs. 9.7±12.8%; P＜0.05). A multiple regression model confirmed that smoking status was independently associated with arterial stiffness (β=0.350, P＜0.001). Conclusion: Current smoking is associated with increased augmentation index, which is a marker of cardiovascular disease. Further studies are required to investigate clinical applications of arterial stiffness. (J Korean Acad Fam Med 2007;28:748-753)
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