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Cardio-Ankle Vascular Index(CAVI), Ankle-Brachial Index(ABI)와 동맥경화 관련 요인과의 상관관계 연구

The Relationship between Cardio-Ankle Vascular Index (CAVI), Ankle-Brachial Index (ABI), and Factors Related to Arteriosclerosis

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Objectives: The cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) are non-invasive methods to evaluate cardiovascular disease and arteriosclerosis. This study investigated the relationship between CAVI, ABI, and factors related to arteriosclerosis. Methods: This study included 535 healthy adults who underwent health examinations in 2019. We analyzed the correlation between CAVI, ABI and clinical variables. Multiple regression analysis was performed on the independent clinical variables associated with CAVI and ABI. Results: The correlation analysis of CAVI showed that body mass index (BMI) and HDL-cholesterol (HDL-C) had a negative correlation, and the other variables had a significant positive correlation. The correlation analysis with ABI on the right side showed that age, diastolic blood pressure (DBP), gender, and LDL-cholesterol (LDL-C) had a significant positive correlation, while HDL-C had a significant negative correlation. There was no statistical significance on the left. In the multiple regression analysis, DBP, age, BMI, gender, and HDL-C were proved to be independent factors in CAVI (right) (R2=0.365); DBP, age, gender, BMI, fasting blood sugar, and total cholesterol in CAVI (left) (R2=0.357); and age, gender, DBP, and systolic blood pressure in ABI (right) (R2=0.133). There were no statistically significant factors in ABI (left). It could be inferred that smoking and drinking are determinants that play an important role in CAVI. Conclusion: CAVI showed a high correlation with gender, age, and blood pressure. A significant correlation between CAVI and serum lipid values could be observed, but this showed a low correlation coefficient. ABI showed a high correlation with age and DBP. These results support the use of CAVI and ABI as primary diagnostic devices in medical treatment.

Abstract

Objectives: The cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) are non-invasive methods to evaluate cardiovascular disease and arteriosclerosis. This study investigated the relationship between CAVI, ABI, and factors related to arteriosclerosis. Methods: This study included 535 healthy adults who underwent health examinations in 2019. We analyzed the correlation between CAVI, ABI and clinical variables. Multiple regression analysis was performed on the independent clinical variables associated with CAVI and ABI. Results: The correlation analysis of CAVI showed that body mass index (BMI) and HDL-cholesterol (HDL-C) had a negative correlation, and the other variables had a significant positive correlation. The correlation analysis with ABI on the right side showed that age, diastolic blood pressure (DBP), gender, and LDL-cholesterol (LDL-C) had a significant positive correlation, while HDL-C had a significant negative correlation. There was no statistical significance on the left. In the multiple regression analysis, DBP, age, BMI, gender, and HDL-C were proved to be independent factors in CAVI (right) (R2=0.365); DBP, age, gender, BMI, fasting blood sugar, and total cholesterol in CAVI (left) (R2=0.357); and age, gender, DBP, and systolic blood pressure in ABI (right) (R2=0.133). There were no statistically significant factors in ABI (left). It could be inferred that smoking and drinking are determinants that play an important role in CAVI. Conclusion: CAVI showed a high correlation with gender, age, and blood pressure. A significant correlation between CAVI and serum lipid values could be observed, but this showed a low correlation coefficient. ABI showed a high correlation with age and DBP. These results support the use of CAVI and ABI as primary diagnostic devices in medical treatment.

참고문헌 (46)

  1. Viles-Gonzalez JF, "Update in atherothrombotic disease", Mt Sinai J Med, 71(3), pp.197~208 (2004)
  2. Simons PCG, "Common carotid intima-media thickness and arterial stiffness:indicators of cardiovascular risk in high-risk patients. The SMART Study (Second Manifestations of ARTerial disease)", Circulation, 100(9), pp.951~957 (1999)
  3. Safar ME, "Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular disease", Circulation, 107(22), pp.2864~2869 (2003)
  4. O'Neal DN, "A cross-sectional study of effects of type 2 diabetes and other cardiovascular risk factor on structure and function of nonstenotic arteries of lower limbs", Diabetes care, 26(1), pp.199~205 (2003)
  5. Kezhu S, "The relationship of pulse wave velocities measured by oscillometric and tonometric methods and clinical application studies", Jpn J Appl physiol, 32(2), pp.81~86 (2002)
  6. Yamnashina A, "Validity, reproducibility, and clinicla significance of noninvasive brachial-ankle pulse wave velocity measurement", Hypertens Res, 25(3), pp.359~364 (2002)
  7. 고경덕, "급성뇌경색 환자와 정상인의 어혈병태 비교", 대한한방내과학회지, 23(3), pp.433~439 (2002), 대한한방내과학회
  8. Ibata J, "Cardio-anklevascular index measures arterial wall stiffness independent of blood pressure", Diabetes Res Clin Pract, 80(2), pp.265~270 (2008)
  9. Yambe T, "Brachio-ankle pulse wave velocity and cardio-ankle vascular index (CAVI)", Biomed Pharmacother, 58(1), pp.S95~8 (2004)
  10. Shirai K, "Cardio-ankle vascular index (CAVI) as a novel indicator of arterial stiffness:theory, evidence and perspectives", J Atheroscler Thromb, 18(11), pp.924~938 (2011)
  11. Saiki A, "The role of a novel arterial stiffness parameter, cardio-ankle vascular index (CAVI), as a surrogate marker for cardiovascular diseases", J Atheroscler Thromb, 23(2), pp.155~168 (2016)
  12. Shirai K, "A novel blood pressure-independent arterial wall stiffness parameter;cardio-ankle vascular index (CAVI)", J Atheroscler Thromb, 13(2), pp.101~107 (2006)
  13. Gómez-Marcos MÁ, "Cardio-ankle vascular index is associated with cardiovascular target organ damage and vascular structure and function in patients with diabetes or metabolic syndrome, LOD-DIABETES study:A case series report", Cardiovasc Diabetol, 14, pp.7~ (2015)
  14. Sun CK, "Cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness", Integr Blood Press Control, 6, pp.27~38 (2013)
  15. WOCN Clinical Practice Wound Subcommittee, "Ankle Brachial Index:quick reference guide for clinicians", J Wound Ostomy Continence Nurs, 39(2), pp.S21~9 (2012)
  16. Formosa C, "Screening for peripheral vascular disease in patients with type 2 diabetes in Malta in a primary care setting", Qual Prim Care, 20(6), pp.409~414 (2012)
  17. Sebastianski M, "Usefulness of the ankle-brachial index to predict high coronary SYNTAX scores, myocardium at risk, and incomplete coronary revascularization", Am J Cardiol, 114(11), pp.1745~1749 (2014)
  18. Criqui MH, "The ankle-brachial index and incident cardiovascular events in the MESA(Multi-Ethnic Study of Atherosclerosis)", J Am Coll Cardiol, 56(18), pp.1506~1512 (2010)
  19. Kubo T, "A simple oscillometric technique for determining new indices of arterial distensibility", Hypertens Res, 25(3), pp.351~358 (2002)
  20. Kweon Sun Seog, "Distribution of the Ankle-Brachial Index and Associated Cardiovascular Risk Factors in a Population of Middle-Aged and Elderly Koreans", Journal of Korean Medical Science, 20(3), pp.373~378 (2005), 대한의학회
  21. Kim HJ, "Utility of brachial-ankle pulse wave velocity, ABI, AI as independent predictor of cardiovascular disease in Korean type2 DM patients", pp.2005
  22. 정승환, "Pulse Wave Velocity(PWV)와 혈청지질수치를 포함한 심혈관 질환 위험 요인들과의 상관관계 연구", 대한한방내과학회지, 30(3), pp.525~533 (2009), 대한한방내과학회
  23. 김석민, "뇌졸중환자의 어혈병태모형과 CAVI, 심혈관질환 위험도간의 상호관계에 관한 임상적 연구", 대한한방내과학회지, 28(3), pp.421~433 (2007), 대한한방내과학회
  24. Statistics Korea, "2017 Cause of Death Statistics", ~ (2018)
  25. 신원준, "뇌경색 환자의 동맥경화와 한방변증과의 관련성 연구", 대한한방내과학회지, 27(1), pp.197~207 (2006), 대한한방내과학회
  26. Ko SG, "Effects of KanghwalSokdantang(KS) on LDL Oxidation in Macrophage Cell", Korean J Orient Int Med, 24(2), pp.203~212 (2003)
  27. 최유경, "혈부축어탕이 대식세포의 oxLDL 생성능에 미치는 영향", 대한한방내과학회지, 23(3), pp.406~414 (2002), 대한한방내과학회
  28. Cho HK, "The Effect of Dodamtang (DDT) on Brain damage and Hypertension", Korean J Orient Int Med, 22(4), pp.503~512 (2001)
  29. O'Rourke MF, "Clinical applications of arterial stiffness;definitions and reference values", Am J Hypertens, 15(5), pp.426~444 (2002)
  30. Lehmann ED, "Relation between number of cardiovascular risk factors", events and noninvasive Doppler ultrasound assessments of aortic compliance, 1998, pp.32(3), 565~569
  31. 신경아, "건강한 노인에서 심장-발목 혈관지수로 측정한 동맥 경직도와체질량 지수간의 상관관계", 대한임상검사과학회지, 51(3), pp.277~285 (2019), 대한임상검사과학회[DOI]
  32. Ohashi N, "The impact of visceral adipose tissue and high-molecular weight adiponectin on cardio-ankle vascular index in asymptomatic Japanese subjects", Metabolism, 58(7), pp.1023~1029 (2009)
  33. Koji Y, "Comparison of ankle- brachial pressure index and pulse wave velocity as markers of the presence of coronary artery disease in subjects with a high risk of atherosclerotic cardiovascular disease", Am J Cardiol, 94(7), pp.868~872 (2004)
  34. Doobay AV, "Sensitivity and specificity of the ankle-brachial index to predict future cardiovascular outcomes:a systematic review", Arterioscler Thromb Vasc Biol, 25(7), pp.1463~1469 (2005)
  35. Koivistoinen T, "Pulse wave velocity reference values in healthy adults aged 26-75 years", Clin Physiol Funct Imaging, 27(3), pp.191~196 (2007)
  36. "Lipid Research Clinics Program;The Lipid Research Clinics Coronary Primary Prevention Trial Results;II Reduction in the incidence of coronary heart disease due to cholesterol lowering", JAMA, 251(3), pp.351~364 (1984)
  37. Lee HJ, "The Change of Serum Lipid Profiles in Korea during 18 Years", Korean J Intern Med, 42(4), pp.500~514 (1992)
  38. Kannel WB, "Update on the role of cigarette smoking in coronary artery disease", Am Heart J, 101(3), pp.319~328 (1981)
  39. Noike H, "Changes in cardio-ankle vascular index in smoking cessation", J Atheroscler Thromb, 17(5), pp.517~525 (2010)
  40. Kubozono T, "Acute and chronic effects of smoking on arterial stiffness", Circ J, 75(3), pp.698~702 (2011)
  41. 현경예, "Comparison of Physiological Variables by Age Group in Drinking Men", 생명과학회지, 19(10), pp.1374~1381 (2009), 한국생명과학회
  42. 김은경, "갱년기 여성의 안면홍조와 맥파 전달 속도(PWV) 및 상완 발목 지수(ABI)의 상관성에 관한 연구", 대한한방부인과학회지, 23(1), pp.53~64 (2010), 대한한방부인과학회
  43. 주선영, "본태성 고혈압 청소년에서 pulse wave velocity와ankle brachial index에 대한 연구", Clinical and Experimental Pediatrics, 49(7), pp.769~776 (2006), 대한소아청소년과학회
  44. 김지혜, "비만 청소년에서 맥파 속도와 발목 상완 동맥압 지수에 대한 연구", Clinical and Experimental Pediatrics, 50(11), pp.1078~1084 (2007), 대한소아청소년과학회
  45. 김지혜, "정상 청소년에서 맥파 속도와 발목 상완 동맥압 지수에 대한 연구", Clinical and Experimental Pediatrics, 50(6), pp.549~555 (2007), 대한소아청소년과학회
  46. Lee JS, "The factors associated with arterial stiffness using the Cardio-Ankle Vascular Index (CAVI) of healthy adults in a University hospital screening center", pp.2013

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