건강한 성인에서 인슐린양 성장 인자-1의 농도 및 관련 요인
Insulin-like Growth Factor 1 Level and Its Relating Factor in Korean Healthy Adults
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연구배경: 성장호르몬 결핍에 대한 진단 및 치료과정에서 성장호르몬 대신 생체지표로서 이용되는 인슐린양 성장 인자-1에 대해서 아직 한국인 정상 참고 범위 등의 연구가 미비한 실정이다. 이에 저자들은 건강한 성인을 대상으로 인슐린양 성장 인자-1 의 농도와 이에 관련된 요소들에 대해 알아보고자 하였다. 방법: 본 연구는 1998년 3월부터 2003년 12월 사이에, 일개 대학 병원에 내원한 20세 이상의 성인 중에 당뇨, 간장 질환, 신장 질환, 갑상선 질환, 뇌하수체 질환, 암 등의 질환이 있는 자를 제외한 10,681명(남: 5,418, 여: 5,263)을 대상으로 하였다. 12시간 이상의 금식 후 인슐린양 성장 인자-1의 농도 및 공복혈당, 총 콜레스테롤, 중성지방 등을 측정하였고 신체계측으로 체질량 지수, 허리둘레, 허리/엉덩이둘레 비 등을 측정하여 인슐린양 성장 인자-1의 연령대별 평균농도 및 관련 요인과의 상관관계를 살펴 보았다. 결과: 20대 이상의 건강한 성인에서 인슐린양 성장 인자-1의 농도는 남자(184.6 ± 86.3 ng/mL)가 여자(178.6 ± 91.8 ng/mL) 보다 높았다. 연령별로 나누어 보았을 때 20대에는 여자가 남자보다 인슐린양 성장 인자-1의 농도가 높았으나, 40대 이후에는 역전되었다. 남녀 모두 나이가 증가할수록 인슐린양 성장 인자-1의 농도가 유의하게 감소하였다. 혈중 인슐린양 성장 인자-1과의 관련 요인으로는 나이의 상관계수가 남자 -0.325, 여자 -0.463 로 가장 높았다. 나이와 체중을 보정한 후에는 남자는 크레아티닌, 총 단백, 알부민, 중성지방, 고밀도 콜레스테롤, 여자는 신장, 체질량 지수, 허리둘레, 허리/엉덩이둘레 비, 수축기혈압, 크레아티닌, 총 단백, 알부민, 중성지방, 고밀도 콜레스테롤 농도와 상관관계를 보였다. 결론: 인슐린양 성장 인자-1의 농도는 남녀 모두 20대 이후 연령증가에 따라 감소하였고, 40대 이후부터 여자의 인슐린양 성장 인자-1 농도가 남자보다 낮아졌다. 남녀 모두 인슐린양 성장인자-1과 나이가 가장 큰 상관계수를 보였다.
Abstract
Background: The concern about growth hormone, used for treatment of growth hormone deficiency, wasting diseases, is increasing recently. There is much to be desired about the study for the reference range of insulin-like growth factor-1 (IGF-1) of Korean healthy adults, because there was a lack of studies of IGF-1 level. The authors investigated the concentration of IGF-1 according to age groups, and its correlation factors in healthy adults in Korea. Methods: The subjects were 10,681 Korean healthy adults (5,263 females, 5,418 males) aged over 20 years, who visited the Department of Family Practice and Community Health in a university hospital from March 1998 to December 2003. We excluded the subjects with DM, liver diseases, renal diseases, thyroid diseases, and cancer. We measured the serum IGF-1, fasting glucose, lipid profile, serum albumin, protein, waist circumference, hip circumference, and body mass index. Results: IGF-1 level showed gender difference (184.6 ± 86.3 ng/mL for men, 178.6 ± 91.8 ng/mL for women) and decreased significantly with age. Age was the most reliable correlation factor with IGF-1 (R: -0.325 for men, R: -0.463 for women). After adjusting fot age and weight, IGF-1 showed correlations with total protein, albumin, creatinine, triglycerides, and HDL cholesterol for men and height, waist circumference, body mass index, waist-hip ratio, systolic blood pressure, total protein, albumin, creatinine, triglycerides, and HDL cholesterol for women. Conclusion: IGF-1 concentration decreased with age over 20 years old. It showed the highest correlation with age in both gender.
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