The Relationship between Obesity and the High Probability of Dementia Based on the Body Mass Index and Waist Circumference
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Background: For an early detection and prevention of dementia, there are growing concerns about the high-risk group for dementia and mild cognitive impairment. With an increase of obesity and its complications, obesity has become a major public health problem. Therefore, the aim of this study was to investigate the relationship between obesity and the high probability of dementia. Methods: This study was done with subjects aged 60 to 89 years who visited a health promotion center, from April 1, 2008 to April 30, 2008. A total of 293 subjects (164 males and 129 females) were included in the evaluation of cognitive function using the Korean version of the Seven Minutes Screen test. Logistic regression models were used to analyze the association between obesity and the high-risk group for dementia. Results: Among a total of 293 subjects, 71 subjects (29 males and 42 females) had a high probability of dementia. When compared to normal body mass index (BMI) group, overweight and obesity groups had about a 2.2-fold and 2.4-fold higher probability of dementia (95% confidence interval [CI], 0.97 to 4.99 and 95% CI, 1.07 to 5.46, respectively). When compared to non-obese and non-abdominal obesity group, non-obese and abdominal obesity group and obese and abdominal obesity group had about a 1.5-fold and 2.0-fold higher probability of dementia (95% CI, 0.59 to 3.95 and 95% CI, 1.09 to 3.84, respectively). Conclusion: This study shows that as the BMI increased, subjects had a higher probability of dementia; additionally, it suggests that abdominal obesity could be related to a higher probability of dementia
Abstract
Background: For an early detection and prevention of dementia, there are growing concerns about the high-risk group for dementia and mild cognitive impairment. With an increase of obesity and its complications, obesity has become a major public health problem. Therefore, the aim of this study was to investigate the relationship between obesity and the high probability of dementia. Methods: This study was done with subjects aged 60 to 89 years who visited a health promotion center, from April 1, 2008 to April 30, 2008. A total of 293 subjects (164 males and 129 females) were included in the evaluation of cognitive function using the Korean version of the Seven Minutes Screen test. Logistic regression models were used to analyze the association between obesity and the high-risk group for dementia. Results: Among a total of 293 subjects, 71 subjects (29 males and 42 females) had a high probability of dementia. When compared to normal body mass index (BMI) group, overweight and obesity groups had about a 2.2-fold and 2.4-fold higher probability of dementia (95% confidence interval [CI], 0.97 to 4.99 and 95% CI, 1.07 to 5.46, respectively). When compared to non-obese and non-abdominal obesity group, non-obese and abdominal obesity group and obese and abdominal obesity group had about a 1.5-fold and 2.0-fold higher probability of dementia (95% CI, 0.59 to 3.95 and 95% CI, 1.09 to 3.84, respectively). Conclusion: This study shows that as the BMI increased, subjects had a higher probability of dementia; additionally, it suggests that abdominal obesity could be related to a higher probability of dementia
참고문헌 (29)
- Suh GH, "Dementia in Korea: trend and projection", J Korean Geriatr Psychiatry, 6, pp.79~87 (2002)
- Qaseem A, "Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians", Ann Intern Med, 148, pp.370~378 (2008)
- Suh GH, "Drug therapy for Alzheimer's disease", J Korean Med Assoc, 50, pp.369~374 (2007)
- Petersen RC, "Mild cognitive impairment: clinical characterization and outcome", Arch Neurol, 56, pp.303~308 (1999)
- Bowen J, "Progression to dementia in patients with isolated memory loss", Lancet, 349, pp.763~765 (1997)
- Braak H, "Spectrum of pathology. In: Petersen RC, editor. Mild cognitive impairment: aging to Alzheimer’s disease", pp.149~189 (2003), Oxford University Press
- 한설희, "알츠하이머병의 새로운 약물치료", 대한의사협회지, 52(11), pp.1059~1068 (2009), 대한의사협회
- Petersen RC, "Mild cognitive impairment: an overview", CNS Spectr, 13, pp.45~53 (2008)
- Haan MN, "Can dementia be prevented? Brain aging in a population-based context", Annu Rev Public Health, 25, pp.1~24 (2004)
- Whitmer RA, "Central obesity and increased risk of dementia more than three decades later", Neurology, 71, pp.1057~1064 (2008)
- 박민선, "한국판 7분 치매 선별 검사의 타당도 연구", Korean Journal of Family Medicine, 23(2), pp.5~739 (2002), 대한가정의학회
- Chobanian AV, "The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report", JAMA, 289, pp.2560~2572 (2003)
- National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), "Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report", Circulation, 106, pp.3143~3421 (2002)
- Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, "Report of the expert committee on the diagnosis and classification of diabetes mellitus", Diabetes Care, 26(1), pp.S5~S20 (2003)
- 박민선, "한국형 7분 치매선별검사의 정상 규준 연구", 대한신경과학회지, 20(3), pp.252~259 (2002), 대한신경과학회
- Solomon PR, "A 7 minute neurocognitive screening battery highly sensitive to Alzheimer's disease", Arch Neurol, 55, pp.349~355 (1998)
- Kim DK, "Clinical efficacy of the 7-Minute Screen at primary care setting", J Korean Acad Fam Med, 21, pp.1131~1138 (2000)
- Bassett J, "World Health Organization, Regional Office for the Western Pacific; International Association for the Study of Obesity; International Obesity Task Force. The Asia Pacific perspective: redefining obesity and its treatment" (2000), Health Communications Australia
- Lee S, "Cut-off points of waist circumference for defining abdominal obesity in the Korean population", Korean J Obes, 15, pp.1~9 (2006)
- Selkoe DJ, "The origins of Alzheimer disease: a is for amyloid", JAMA, 283, pp.1615~1617 (2000)
- Lathe R, "Hormones and the hippocampus", J Endocrinol, 169, pp.205~231 (2001)
- Ren J, "Leptin and hyperleptinemia - from friend to foe for cardiovascular function", J Endocrinol, 181, pp.1~10 (2004)
- Fewlass DC, "Obesity-related leptin regulates Alzheimer's Abeta", FASEB J, 18, pp.1870~1878 (2004)
- Bjorntorp P, "Neuroendocrine abnormalities in visceral obesity", Int J Obes Relat Metab Disord, 24(2), pp.S80~S85 (2000)
- Vermeer SE, "Silent brain infarcts and the risk of dementia and cognitive decline", N Engl J Med, 348, pp.1215~1222 (2003)
- Waldstein SR, "Stress-induced blood pressure reactivity and silent cerebrovascular disease", Stroke, 35, pp.1294~1298 (2004)
- Honig LS, "Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center", Neurology, 64, pp.494~500 (2005)
- Poirier P, "Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism", Circulation, 113, pp.898~918 (2006)
- Jeong SK, "Interactive effect of obesity indexes on cognition", Dement Geriatr Cogn Disord, 19, pp.91~96 (2005)