Relationship between Changes in Fatigue and Exercise by Follow-Up Period
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Background: Fatigue is one of the most common presenting symptoms in primary care in Korea. In this study, weaimed to determine the effect of exercise intervention on the severity of fatigue of unknown medical cause during aperiod of follow-up. Methods: We used the data collected from an outpatient fatigue clinic in Seoul National University Bundang Hospital. The study was conducted from March 3, 2010 to May 31, 2014. We measured the body mass index of each patientand evaluated variables including lifestyle factors (smoking, alcohol consumption, and regular exercise),quality of sleep, anxiety, depression, stress severity, and fatigue severity using questionnaires. A total of 152 participantswho completed questionnaires to determine changes in fatigue severity and the effect of exercise for each periodwere evaluated. We used univariate analysis to verify possible factors related to fatigue and then conductedmultivariate analysis using these factors and the literature. Results: Of 130 patients with the complaint of chronic fatigue for over 6 months, over 90 percent reported moderateor severe fatigue on the Fatigue Severity Scale and Brief Fatigue Inventory questionnaires. The fatigue severityscores decreased and fatigue improved over time. The amount of exercise was increased in the first month, but decreasedafterwards. Conclusion: There was no significant relationship between changes in the amount of exercise and fatigue severityin each follow-up period. Randomized controlled trials and a cohort study with a more detailed exercise protocolin an outpatient setting are needed in the future.
Abstract
Background: Fatigue is one of the most common presenting symptoms in primary care in Korea. In this study, weaimed to determine the effect of exercise intervention on the severity of fatigue of unknown medical cause during aperiod of follow-up. Methods: We used the data collected from an outpatient fatigue clinic in Seoul National University Bundang Hospital. The study was conducted from March 3, 2010 to May 31, 2014. We measured the body mass index of each patientand evaluated variables including lifestyle factors (smoking, alcohol consumption, and regular exercise),quality of sleep, anxiety, depression, stress severity, and fatigue severity using questionnaires. A total of 152 participantswho completed questionnaires to determine changes in fatigue severity and the effect of exercise for each periodwere evaluated. We used univariate analysis to verify possible factors related to fatigue and then conductedmultivariate analysis using these factors and the literature. Results: Of 130 patients with the complaint of chronic fatigue for over 6 months, over 90 percent reported moderateor severe fatigue on the Fatigue Severity Scale and Brief Fatigue Inventory questionnaires. The fatigue severityscores decreased and fatigue improved over time. The amount of exercise was increased in the first month, but decreasedafterwards. Conclusion: There was no significant relationship between changes in the amount of exercise and fatigue severityin each follow-up period. Randomized controlled trials and a cohort study with a more detailed exercise protocolin an outpatient setting are needed in the future.
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