The Prevalence of Gallstone Disease Is Significantly Lower in Natives than in Migrants of Jeju Island
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Background: The eating habits of Jeju Island natives are quite different from those of the mainland people because of geographic isolation. Diet is a main factor affecting gallstone disease. We investigated the prevalence of gallstone disease in both Jeju Island natives and migrants and studied the risk factors affecting gallstone disease in the Jeju Island people.Methods: A total of 20,763 subjects who underwent medical checkups at the Health Promotion Center of Jeju Na-tional University Hospital in Korea from January 2003 to December 2015 were enrolled in the study. Ultrasonogra-phy was used to determine the presence of gallbladder stones. Body mass index and biochemical parameters, in-cluding liver function test results, lipid profiles, and fasting blood glucose levels, were verified, and data on age, birthplace, and sex were collected from medical records. Univariate and multivariate analyses were performed to identify risk factors affecting gallstone disease.Results: The prevalence of gallstone disease in the Jeju Island people was 4.0%: Jeju Island natives, 3.8% and mi-grants, 4.4% (P=0.047). After multivariate logistic regression analysis, the independent risk factors were older age, Jeju migrants, higher fasting blood glucose and alanine aminotransferase levels, and lower high-density lipoprotein cholesterol levels.Conclusion: The prevalence of gallstone disease was significantly lower in natives than in migrants from Jeju Is-land. Older age, Jeju migrants, higher fasting blood glucose and alanine aminotransferase levels, and lower high-density lipoprotein cholesterol levels contributed to gallstone disease prevalence in the Jeju Island people.
Abstract
Background: The eating habits of Jeju Island natives are quite different from those of the mainland people because of geographic isolation. Diet is a main factor affecting gallstone disease. We investigated the prevalence of gallstone disease in both Jeju Island natives and migrants and studied the risk factors affecting gallstone disease in the Jeju Island people.Methods: A total of 20,763 subjects who underwent medical checkups at the Health Promotion Center of Jeju Na-tional University Hospital in Korea from January 2003 to December 2015 were enrolled in the study. Ultrasonogra-phy was used to determine the presence of gallbladder stones. Body mass index and biochemical parameters, in-cluding liver function test results, lipid profiles, and fasting blood glucose levels, were verified, and data on age, birthplace, and sex were collected from medical records. Univariate and multivariate analyses were performed to identify risk factors affecting gallstone disease.Results: The prevalence of gallstone disease in the Jeju Island people was 4.0%: Jeju Island natives, 3.8% and mi-grants, 4.4% (P=0.047). After multivariate logistic regression analysis, the independent risk factors were older age, Jeju migrants, higher fasting blood glucose and alanine aminotransferase levels, and lower high-density lipoprotein cholesterol levels.Conclusion: The prevalence of gallstone disease was significantly lower in natives than in migrants from Jeju Is-land. Older age, Jeju migrants, higher fasting blood glucose and alanine aminotransferase levels, and lower high-density lipoprotein cholesterol levels contributed to gallstone disease prevalence in the Jeju Island people.
참고문헌 (30)
- Jorgensen T, "The epidemiology of gallstones in a 70-year-old Danish population", Scand J Gastroenterol, 25, pp.335~340 (1990)
- Shoda J, "Increase of deoxycholate in supersaturated bile of patients with cholesterol gallstone disease and its correlation with de novo syntheses of cholesterol and bile acids in liver, gallbladder emptying, and small intestinal transit", Hepatology, 21, pp.1291~1302 (1995)
- Angelico F, "Ten-year incidence and natural history of gallstone disease in a rural population of women in central Italy. The Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO)", Ital J Gastroenterol Hepatol, 29, pp.249~254 (1997)
- Barbara L, "A population study on the prevalence of gallstone disease: the Sirmione Study", Hepatology, 7, pp.913~917 (1987)[DOI]
- Berger MY, "Abdominal symptoms: do they predict gallstones?: a systematic review", Scand J Gastroenterol, 35, pp.70~76 (2000)[DOI]
- Jorgensen T, "Prevalence of gallstones in a Danish population", Am J Epidemiol, 126, pp.912~921 (1987)[DOI]
- Scragg RK, "Diet, alcohol, and relative weight in gall stone disease: a case-control study", Br Med J (Clin Res Ed), 288, pp.1113~1119 (1984)[DOI]
- Maclure KM, "Weight, diet, and the risk of symptomatic gallstones in middleaged women", N Engl J Med, 321, pp.563~569 (1989)[DOI]
- White paper on liver disease Korea 2013, "Korean Association for the Study of the Liver", ~ (2014)
- Cooperberg PL, "Real-time ultrasonography: diagnostic technique of choice in calculous gallbladder disease", N Engl J Med, 302, pp.1277~1279 (1980)[DOI]
- WHO Expert Consultation, "Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies", Lancet, 363, pp.157~163 (2004)[DOI]
- American Diabetes Association, "(2) Classification and diagnosis of diabetes", Diabetes Care, 38(Suppl), pp.S8~S16 (2015)
- Committee for Guidelines for Management of Dyslipidemia, "2015 Korean guidelines for management of dyslipidemia", J Lipid Atheroscler, 4, pp.61~92 (2015)[DOI]
- Sohn W, "Upper limit of normal serum alanine and aspartate aminotransferase levels in Korea", J Gastroenterol Hepatol, 28, pp.522~529 (2013)[DOI]
- Lee JK, "Prevalence and risk factors of gallstone in health screening people", Korean J Gastroenterol, 29, pp.85~92 (1997)
- Yi SY, "Clinical study on gallstone prevalence in general health screening people", Korean J Med, 47, pp.352~358 (1994)
- Hwang SW, "Associated factor of prevalence of asymptomatic gallstone", J Korean Acad Fam Med, 22, pp.1596~1602 (2001)
- 정윤진, "건강검진자에서 담낭 담석의 유병률과 위험인자", 대한내과학회지, 72(5), pp.480~490 (2007), 대한내과학회
- Misciagna G, "Diet, physical activity, and gallstones: a population-based, casecontrol study in southern Italy", Am J Clin Nutr, 69, pp.120~126 (1999)[DOI]
- Acalovschi M, "Cholesterol gallstones: from epidemiology to prevention", Postgrad Med J, 77, pp.221~229 (2001)[DOI]
- Einarsson K, "Influence of age on secretion of cholesterol and synthesis of bile acids by the liver", N Engl J Med, 313, pp.277~282 (1985)[DOI]
- Diehl AK, "Cholelithiasis and the insulin resistance syndrome", Hepatology, 31, pp.528~530 (2000)[DOI]
- Ruhl CE, "Association of diabetes, serum insulin, and Cpeptide with gallbladder disease", Hepatology, 31, pp.299~303 (2000)[DOI]
- Nepokroeff CM, "Regulation of the diurnal rhythm of rat liver beta-hydroxy-beta-methylglutaryl coenzmye A reductase activity by insulin, glucagon, cyclic AMP and hydrocortisone", Arch Biochem Biophys, 160, pp.387~396 (1974)[DOI]
- Yang LS, "A study on college student's understanding and preference of native foods in Cheju-do, Korea", Korean J Diet Cult, 5, pp.317~330 (1990)
- [URL]
- Mathur A, "High dietary carbohydrates decrease gallbladder volume and enhance cholesterol crystal formation", Surgery, 141, pp.654~659 (2007)[DOI]
- Thornton J, "Moderate alcohol intake reduces bile cholesterol saturation and raises HDL cholesterol", Lancet, 2, pp.819~822 (1983)
- Nestel PJ, "Effects of ethanol on bile acid and cholesterol metabolism", Am J Clin Nutr, 29, pp.1007~1015 (1976)[DOI]
- Probert CS, "Some determinants of wholegut transit time: a population-based study", QJM, 88, pp.311~315 (1995)