본문 바로가기
KERD
논문KCI 등재

A Case Report of Rare Adverse Events Associated with Venlafaxine Administration: Hypoglycemia and Lactic Acidosis

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류가정의학

초록

We report the first case of hypoglycemia and lactic acidosis caused by the therapeutic doses of venlafaxine. A 19-year-old female patient had presyncope and she was taking venlafaxine 75 mg once a day because of major de-pression for a week and she had no history of any other drug use or disease. The blood gas analysis revealed hypo-glycemia and lactic acidosis. Patient was treated with dextrose infusion and oral diet. Although hypoglycemia and lactic acidosis have been reported in overdose of venlafaxine in the literature, these effects were observed in thera-peutic doses.

Abstract

We report the first case of hypoglycemia and lactic acidosis caused by the therapeutic doses of venlafaxine. A 19-year-old female patient had presyncope and she was taking venlafaxine 75 mg once a day because of major de-pression for a week and she had no history of any other drug use or disease. The blood gas analysis revealed hypo-glycemia and lactic acidosis. Patient was treated with dextrose infusion and oral diet. Although hypoglycemia and lactic acidosis have been reported in overdose of venlafaxine in the literature, these effects were observed in thera-peutic doses.

참고문헌 (10)

  1. Eldem I, "Venlafaxine intoxication in an adolescent presenting with severe lactic acidosis", Turk J Pediatr, 58, pp.200~202 (2016)
  2. Meertens JH, "Severe hypoglycemia following venlafaxine intoxication : a case report", J Clin Psychopharmacol, 27, pp.414~415 (2007)
  3. Brvar M, "Hypoglycemia in venlafaxine overdose : a hypothesis of increased glucose uptake", Eur J Clin Pharmacol, 71, pp.261~262 (2015)
  4. Francino MC, "Hypoglycaemia: a little known effect of Venlafaxine overdose", Clin Toxicol(Phila), 50, pp.215~217 (2012)
  5. Ling Y, "Persistent hypoglycemia in venlafaxine overdose", Arch Clin Med Case Rep, 3, pp.94~99 (2019)
  6. Derijks HJ, "The association between antidepressant use and disturbances in glucose homeostasis : evidence from spontaneous reports", Eur J Clin Pharmacol, 64, pp.531~538 (2008)
  7. Yamada J, "Serotonininduced hypoglycemia and increased serum insulin levels in mice", Life Sci, 45, pp.1931~1936 (1989)
  8. Chi TC, "Serotonin enhances beta-endorphin secretion to lower plasma glucose in streptozotocin-induced diabetic rats", Life Sci, 80, pp.1832~1838 (2007)
  9. Iragavarapu C, "Type B lactic acidosis associated with venlafaxine overdose", Am J Ther, 23, pp.e1082~e1094 (2016)
  10. Hroudova J, "Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers", Neuro Endocrinol Lett, 31, pp.336~342 (2010)

관련 논문AI추천

이 간행물의 다른 논문 (11건)