Association between Processed Meat Protein Consumption and Incident Osteoporosis in Adults Aged 50 Years and Older: A Prospective Cohort Study Based on Korean Genome and Epidemiology Study Data (2005–2020)
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Background: Osteoporosis is one of the inevitable diseases affecting an aging society, substantially impacting the quality of life of its population. Protein intake has been shown to be beneficial in reducing the incidence of osteoporosis, and the effects of both animal and vegetable proteins have been studied. However, the relationship between processed meat consumption and osteoporosis has not been studied in Korea. Therefore, we aimed to analyze the correlation between processed meat consumption and incident osteoporosis in adults. Methods: Our analysis included 1,260 adults aged 50 years and older from the Korean Genome and Epidemiology Study (KoGES), recruited between 2005 and 2020. Participants were categorized into two groups according to their processed meat intake, assessed using a semi-quantitative 103-food item food frequency questionnaire. Diagnosis of osteoporosis was based on questionnaire answers. Multiple Cox hazard regression analyses were conducted to examine the association between processed meat intake and incident osteoporosis. Results: During an average follow-up period of 8.8 years, 230 participants developed osteoporosis. According to the Cox proportional regression models, the hazard ratio (95% confidence interval) of incident osteoporosis in the high intake group was 0.62 (0.41–0.94), compared to the low intake group after adjusting for confounding variables. Conclusion: These findings reveal that processed meat protein intake is inversely related to the incidence of osteoporosis in adults aged 50 years and older. This in turn suggests that processed meat intake can be proposed as an additional strategy to prevent osteoporosis.
Abstract
Background: Osteoporosis is one of the inevitable diseases affecting an aging society, substantially impacting the quality of life of its population. Protein intake has been shown to be beneficial in reducing the incidence of osteoporosis, and the effects of both animal and vegetable proteins have been studied. However, the relationship between processed meat consumption and osteoporosis has not been studied in Korea. Therefore, we aimed to analyze the correlation between processed meat consumption and incident osteoporosis in adults. Methods: Our analysis included 1,260 adults aged 50 years and older from the Korean Genome and Epidemiology Study (KoGES), recruited between 2005 and 2020. Participants were categorized into two groups according to their processed meat intake, assessed using a semi-quantitative 103-food item food frequency questionnaire. Diagnosis of osteoporosis was based on questionnaire answers. Multiple Cox hazard regression analyses were conducted to examine the association between processed meat intake and incident osteoporosis. Results: During an average follow-up period of 8.8 years, 230 participants developed osteoporosis. According to the Cox proportional regression models, the hazard ratio (95% confidence interval) of incident osteoporosis in the high intake group was 0.62 (0.41–0.94), compared to the low intake group after adjusting for confounding variables. Conclusion: These findings reveal that processed meat protein intake is inversely related to the incidence of osteoporosis in adults aged 50 years and older. This in turn suggests that processed meat intake can be proposed as an additional strategy to prevent osteoporosis.
참고문헌 (20)
- Kanis JA, "Assessment of fracture risk and its application to screening for postmenopausal osteoporosis : synopsis of a WHO report. WHO Study Group", Osteoporos Int, 4, pp.368~381 (1994)
- Ha YC, "Epidemiology of osteoporosis in Korea", J Korean Med Assoc, 59, pp.836~841 (2016)
- Abelow BJ, "Cross-cultural association between dietary animal protein and hip fracture : a hypothesis", Calcif Tissue Int, 50, pp.14~18 (1992)
- Heaney RP, "Amount and type of protein influences bone health", Am J Clin Nutr, 87, pp.1567~ (2008)
- Hannan MT, "Effect of dietary protein on bone loss in elderly men and women : the Framingham Osteoporosis Study", J Bone Miner Res, 15, pp.2504~2512 (2000)
- Sellmeyer DE, "A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group", Am J Clin Nutr, 73, pp.118~122 (2001)
- Shams-White MM, "Animal versus plant protein and adult bone health : a systematic review and meta-analysis from the National Osteoporosis Foundation", PLoS One, 13, pp.e0192459~ (2018)
- Ham H, "Trends in dietary protein intake and its adequacy among Korean adults : data from the 2010-2019 Korea National Health and Nutrition Examination Survey(KNHANES)", Korean J Community Nutr, 27, pp.47~60 (2022)
- Rohrmann S, "Processed meat : the real villain?", Proc Nutr Soc, 75, pp.233~241 (2016)
- Kim Y, "Cohort profile : the Korean Genome and Epidemiology Study(KoGES)consortium", Int J Epidemiol, 46, pp.e20~ (2017)
- Ahn Y, "Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study", Eur J Clin Nutr, 61, pp.1435~1441 (2007)
- Craig CL, "International Physical Activity Questionnaire : 12-country reliability and validity", Med Sci Sports Exerc, 35, pp.1381~1395 (2003)
- Ainsworth BE, "Compendium of physical activities : an update of activity codes and MET intensities", Med Sci Sports Exerc, 32, pp.S498~S504 (2000)
- Kim J, "The relationship between platelet count and bone mineral density : results from two independent population-based studies", Arch Osteoporos, 15, pp.43~ (2020)
- Qing GZ, "The relationship of frequency of meat consumption and osteoporosis in Chinese postmenopausal women", Int J Clin Exp Med, 8, pp.21130~21137 (2015)
- IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, "Red meat and processed meat" (2018), International Agency for Research on Cancer
- Research on preparing a proper intake plan for red meat and processed meat, "Lee JK", Ministry of Food and Drug Safety, ~ (2016)
- Park SJ, "Dietary patterns and osteoporosis risk in postmenopausal Korean women", Osong Public Health Res Perspect, 3, pp.199~205 (2012)
- Munoz-Garach A, "Nutrients and dietary patterns related to osteoporosis", Nutrients, 12, pp.1986~ (2020)
- Larkin FA, "Comparison of estimated nutrient intakes by food frequency and dietary records in adults", J Am Diet Assoc, 89, pp.215~223 (1989)