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Synthesis and Antimicrobial Activity of Dimethyl (2-cyanophenylamino) (Substituted Aryl) Methyl Phosphonates

C. Suresh Reddy|G. Chandra Sekhar Reddy|B. Siva Kumar|A. Uma Ravi Sankar|M. Veera Narayana Reddy
대한화학회|2008.12|대한화학회지 (Journal of the Korean Chemical Society)|제52권 제6호|pp. 657-662

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참고문헌

키워드

Antimicrobial Activity2-amino BenzonitrileDimethylphosphiteKabachnic-Fields Reactionα-aminophosphonic Acid Esters2-아미노 벤조니트릴디메틸아인산염Kabachnic-Fields 반응α-아미노포스포산 에스테르항균활성도
주제분류화학

초록

A new class of α-aminophosphonic acid esters (4a-l) have been synthesized by three component one-pot reaction with equimolar quantities of 2-amino benzonitrile (1), dimethylphosphite (3) and various aldehydes (2a-l) in dry toluene at reflux conditions via Kabachnic-Fields reaction in high yields (74-85%).The structure of title compounds has been established by elemental, IR, 1H, 13C, 31P and Mass spectral analysis. They were found to possess significant antimicrobial activity.

Abstract

A new class of α-aminophosphonic acid esters (4a-l) have been synthesized by three component one-pot reaction with equimolar quantities of 2-amino benzonitrile (1), dimethylphosphite (3) and various aldehydes (2a-l) in dry toluene at reflux conditions via Kabachnic-Fields reaction in high yields (74-85%).The structure of title compounds has been established by elemental, IR, 1H, 13C, 31P and Mass spectral analysis. They were found to possess significant antimicrobial activity.

참고문헌 (36)

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