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Highly Convenient and Large Scale Synthesis of 5-chloroindole and its 3-substituted Analogues

Laxminarayana Keetha|Vinodkumar Ramanatham|Sadanandam Palle|Mukkanti Khagga|Rajendiran Chinnapillai
대한화학회|2011.04|대한화학회지 (Journal of the Korean Chemical Society)|제55권 제2호|pp. 240-242

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참고문헌

키워드

5-haloindolescopper (I) chlorideN-methyl-2-pyrrolidonehalogen-halogen exchange염화 구리 (I)halogen-halogen 교환반응
주제분류화학

초록

A large scale and commercially feasible synthesis of 5-chloroindole and its 3-substituted analogues has been described via a halogen - halogen exchange reaction from 5-bromoindole and its derivatives using cuprous chloride and dipolar aprotic solvent N-methyl-2-pyrrolidone in one pot with good yields.

Abstract

CuCl과 N-methyl-2-pyrrolidone을 이용하여 5-bromoindole을 halogen - halogen 교환반응을 통하여 5-chloroindole계화합물을 합성하는 one-pot대량합성방법을 개발하였다.

참고문헌 (19)

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