신생아의 급성신손상
Acute Kidney Injury in the Newborn: Etiology, Pathophysiology and Diagnosis
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Acute kidney injury (AKI), formerly referred to as acute renal failure (ARF) is defined as the sudden impairment of kidney function (estimated from the glomerular filtration rate [GFR]) that results in the lack of excretion of waste products. More than 30 definitions of AKI exist in the literature, most of which are based on serum creatinine. Lack of a uniform and multidimensional AKI definition has led to failure to recognize significant renal injury, delays in treatment, and inability to generalize single-study results. The RIFLE criteria were developed to standardize the diagnosis of ARF and in the process the term AKI has been proposed to encompass the entire spectrum of the syndrome from minor changes in renal function to requirement for renal replacement therapy. Large prospective studies are needed to test definitions and to better understand risk factors, incidence, independent outcomes, and mechanisms that lead to poor short- and long-term outcomes. Early biomarkers of AKI need to be explored in critically ill neonates.
Abstract
Acute kidney injury (AKI), formerly referred to as acute renal failure (ARF) is defined as the sudden impairment of kidney function (estimated from the glomerular filtration rate [GFR]) that results in the lack of excretion of waste products. More than 30 definitions of AKI exist in the literature, most of which are based on serum creatinine. Lack of a uniform and multidimensional AKI definition has led to failure to recognize significant renal injury, delays in treatment, and inability to generalize single-study results. The RIFLE criteria were developed to standardize the diagnosis of ARF and in the process the term AKI has been proposed to encompass the entire spectrum of the syndrome from minor changes in renal function to requirement for renal replacement therapy. Large prospective studies are needed to test definitions and to better understand risk factors, incidence, independent outcomes, and mechanisms that lead to poor short- and long-term outcomes. Early biomarkers of AKI need to be explored in critically ill neonates.
참고문헌 (25)
- Askenazi DJ, "Acute kidney injury in critically ill newborns: what do we know? What do we need to learn?", Pediatr Nephrol, 24, pp.265~274 (2009)
- Bellomo R, "Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group", Crit Care, 8, pp.204~212 (2004)
- Akcan-Arikan A, "Modified RIFLE criteria in critically ill children with acute kidney injury", Kidney Int, 71, pp.1028~1035 (2007)
- Plotz FB, "Pediatric acute kidney injury in the ICU: an independent evaluation of pRIFLE criteria", Intensive Care Med, 34, pp.1713~1717 (2008)
- Abrahamson DR, "Glomerulogenesis in the developing kidney", Semin Nephrol, 11, pp.375~389 (1991)
- Karlowicz MG, "Nonoliguric and oliguric acute renal failure in asphyxiated term neonates", Pediatr Nephrol, 9, pp.718~722 (1995)
- Olavarria F, "Renal function in full-term newborns following neonatal asphyxia. A prospective study", Clin Pediatr (Phila), 26, pp.334~338 (1987)
- Andreoli SP, "Acute renal failure in the newborn", Semin Perinatol, 28, pp.112~123 (2004)
- Moghal NE, "A review of acute renal failure in children: incidence, etiology and outcome", Clin Nephrol, 49, pp.91~95 (1998)
- Brion LP, "A simple estimate of glomerular filtration rate in low birth weight infants during the first year of life: noninvasive assessment of body composition and growth", J Pediatr, 109, pp.698~707 (1986)
- Schwartz GJ, "Glomerular filtration rate measurement and estimation in chronic kidney disease", Pediatr Nephrol, 22, pp.1839~1848 (2007)
- Gallini F, "Progression of renal function in preterm neonates with gestational age < or = 32 weeks", Pediatr Nephrol, 15, pp.119~124 (2000)
- Vieux R, "Glomerular filtration rate reference values in very preterm infants", Pediatrics, 125, pp.1186~1192 (2010)
- Hentschel R, "Renal insufficiency in the neonatal period", Clin Nephrol, 46, pp.54~58 (1996)
- Devarajan P, "Update on mechanisms of ischemic acute kidney injury", J Am Soc Nephrol, 17, pp.1503~1520 (2006)
- Bonventre JV, "Recent advances in the pathophysiology of ischemic acute renal failure", J Am Soc Nephrol, 14, pp.2199~2210 (2003)
- Devarajan P, "Cellular and molecular derangements in acute tubular necrosis", Curr Opin Pediatr, 17, pp.193~199 (2005)
- Gupta IR, "Spontaneous resolution of upper urinary tract obstruction in an anuric premature neonate", Pediatr Nephrol, 10, pp.544~545 (1996)
- Naughton CA, "Drug-induced nephrotoxicity", Am Fam Physician, 78, pp.743~750 (2008)
- Akcay A, "Mediators of inflammation in acute kidney injury", Mediators Inflamm, 2009, pp.13702~ (2009)
- Schrier RW, "Acute renal failure and sepsis", N Engl J Med, 351, pp.159~169 (2004)
- Coca SG, "Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review", Kidney Int, 73, pp.1008~1016 (2008)
- Ronco C, "Oliguria, creatinine and other biomarkers of acute kidney injury", Contrib Nephrol, 164, pp.118~127 (2010)
- Edelstein CL, "Biomarkers of acute kidney injury", Adv Chronic Kidney Dis, 15, pp.222~234 (2008)
- Srisawat N, "Recovery from acute kidney injury: determinants and predictors", Contrib Nephrol, 165, pp.284~291 (2010)