Timolol 국소 도포를 이용한 영아 혈관종 치험 3례
Three Cases of Infantile Hemanioma Treated with Topical Timolol
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초록
영아 혈관종은 영유아기의 가장 흔한 종양으로, 대부분 1세 이후 자연 퇴축되는 것으로 알려져 있으나, 혈관증식이심한 경우에는 퇴축 후라도 위축된 반흔이 남는 수가 많다. 따라서, 미용적 측면에서 볼 때 증식기에 적극적으로 치료할 필요가 있다. 치료제로 corticosteroid, propranolol 등이 사용되기는 하나, 전신적인 부작용이 발생할 수 있다. 최근2-3년 사이에, 안과 영역에서 녹내장 치료제로 사용하는 0.5% Timolol maleate 점안액을 피부 병변에 적용하여 영아혈관종을 치료하고자 하는 연구 시도가 있어 왔고 또 좋은 결과를 보고하고 있다. 저자들은 증식이 심한 혈관종을 가진3명의 영아에게 timolol maleate 용액을 이용하여 치료한 사례를 경험하였기에 이를 보고하는 바이다.
Abstract
Infantile hemangioma is a common, benign tumor of infancy. Although systemicpropranolol was found to be effective in the treatment of infantile hemangioma, itsuse is often challenging for clinicians owing to its potential side effects. Recent smallstudies have suggested that the topical use of timolol maleate gel, a non-selectivebeta-adrenergic antagonist, might be effective for the treatment of superficial infantilehemangioma. Here, we report three cases of infantile hemangioma of different sizesand depths treated with the topical timolol maleate gel-forming solution.
참고문헌 (20)
- Kilcline C, "Infantile hemangiomas: how common are they? A systematic review of the medical literature", Pediatr Dermatol, 25, pp.168~173 (2008)
- George ME, "Adverse effects of systemic glucocorticosteroid therapy in infants with hemangiomas", Arch Dermatol, 140, pp.963~969 (2004)
- de Graaf M, "Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants", J Am Acad Dermatol, 65, pp.320~327 (2011)
- Worle H, "Interferon alpha-2a therapy in haemangiomas of infancy: spastic diplegia as a severe complication", Eur J Pediatr, 158, pp.344~ (1999)
- Chakkittakandiyil A, "Timolol maleate 0.5% or 0.1% gel-forming solution for infantile hemangiomas: a retrospective, multicenter, cohort study", Pediatr Dermatol, 29, pp.28~31 (2012)
- Guo S, "Topical treatment for capillary hemangioma of the eyelid using beta-blocker solution", Arch Ophthalmol, 128, pp.255~256 (2010)
- Ni N, "Topical timolol for periocular hemangioma: report of further study", Arch Ophthalmol, 129, pp.377~379 (2011)
- Pope E, "Topical timolol gel for infantile hemangiomas: a pilot study", Arch Dermatol, 146, pp.564~565 (2010)
- Semkova K, "Topical timolol maleate for treatment of infantile haemangiomas: preliminary results of a prospective study", Clin Exp Dermatol, 38, pp.143~146 (2013)
- Xue K, "Deep periocular infantile capillary hemangiomas responding to topical application of timolol maleate, 0.5%, drops", JAMA Ophthalmol, 131, pp.1246~1248 (2013)
- Blatt J, "beta-blockers for infantile hemangiomas: a single-institution experience", Clin Pediatr (Phila), 50, pp.757~763 (2011)
- Drolet BA, "Hemangiomas in children", N Engl J Med, 341, pp.173~181 (1999)
- Chang LC, "Growth characteristics of infantile hemangiomas:implications for management", Pediatrics, 122, pp.360~367 (2008)
- Zarem HA, "Induced resolution of cavernous hemangiomas following prednisolone therapy", Plast Reconstr Surg, 39, pp.76~83 (1967)
- Boon LM, "Complications of systemic corticosteroid therapy for problematic hemangioma", Plast Reconstr Surg, 104, pp.1616~1623 (1999)
- Lomenick JP, "Growth, bone mineral accretion, and adrenal function in glucocorticoid-treated infants with hemangiomas-- a retrospective study", Pediatr Dermatol, 23, pp.169~174 (2006)
- Leaute-Labreze C, "Propranolol for severe hemangiomas of infancy", N Engl J Med, 358, pp.2649~2651 (2008)
- D'Angelo G, "cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation", J Cell Biochem, 67, pp.353~366 (1997)
- Holland KE, "Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma", Arch Dermatol, 146, pp.775~778 (2010)
- Breur JM, "Hypoglycemia as a result of propranolol during treatment of infantile hemangioma: a case report", Pediatr Dermatol, 28, pp.169~171 (2011)