파킨슨병 환자와 정상 노인의 음성비교
A Comparison of the Voice Differences of Patients with Idiopathic Parkinson's Disease and a Normal-Aging Group
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In view of the hypothesis that the effects of Parkinson disease on voice production can be detected before pharmacological intervention, the voice differences of patients with Idiopathic Parkinson's disease and a healthy aging group were diagnostically analyzed with the long term object of establishing, for clinical purposes, early disease-progression biomarkers. Fifteen patients with Idopathic Parkinson's disease (prior to pharmacological intervention) and a healthy control group of 15 were selected and every voice was recorded three times using praat (ver. 5022) with a headset mic. Relevant parameters - acoustic measure of /a/ phonation, F0 related parameters, MPT related parameters, articulatory ratio, VOT - were then analyzed by MANOVA. Significant differences were found in the F0 related (low F0, high F0, F0 range) and MPT related parameters. There were also significant differences in acoustic measurements (intensity, shimmer, HNR, jitter), AMR (/tʌ/,/kʌ/) and VOT (/ta/). The findings indicated that the voice production of patients with Idiopathic Parkinson's disease have normal pitch but bad quality. In particular, with slow articulatory ratios and VOT values, the tongue tip functioning of patients was lower than for the healthy group.
Abstract
In view of the hypothesis that the effects of Parkinson disease on voice production can be detected before pharmacological intervention, the voice differences of patients with Idiopathic Parkinson's disease and a healthy aging group were diagnostically analyzed with the long term object of establishing, for clinical purposes, early disease-progression biomarkers. Fifteen patients with Idopathic Parkinson's disease (prior to pharmacological intervention) and a healthy control group of 15 were selected and every voice was recorded three times using praat (ver. 5022) with a headset mic. Relevant parameters - acoustic measure of /a/ phonation, F0 related parameters, MPT related parameters, articulatory ratio, VOT - were then analyzed by MANOVA. Significant differences were found in the F0 related (low F0, high F0, F0 range) and MPT related parameters. There were also significant differences in acoustic measurements (intensity, shimmer, HNR, jitter), AMR (/tʌ/,/kʌ/) and VOT (/ta/). The findings indicated that the voice production of patients with Idiopathic Parkinson's disease have normal pitch but bad quality. In particular, with slow articulatory ratios and VOT values, the tongue tip functioning of patients was lower than for the healthy group.
참고문헌 (17)
- S. Pino, "Treatments for dysarthria in Parkinson's disease", Lancet Neurology, 3, pp.547~556 (2004)
- 이애영, "파킨슨씨병 환자의 행동신경학적 특성에 관한 연구", 박사, pp.1996
- 최선아, "한국 파킨슨병 환자의 진단전 상황", 대한신경과학지, 18(6), pp.687~693 (2000)
- T. Joseph, "임상약물백과사전 6판" (2005), 조윤커뮤니케이션
- J. R. Duffy, "Motor Speech Disorders: substrates, differential diagnosis and management" (2005), Mosby
- 대한이비인후과학회, "이비인후과학-두경부외과학" (2002), 일조각
- 배기훈, "노인 환자에서의 음성학적 특성", 대한음성언어의학회지, 16(2), pp.135~139 (2005)
- S. E. Linville, "Vocal Aging" (2001), Singular
- 이준영, "파킨슨병 환자 언어의 음성학적 분석", 석사, pp.2007
- 박성혜, "파킨슨병 화자의 양순 파열음 산출 능력에 관한 음향학적 연구", 석사, pp.2002
- 성지은, "시상하핵 뇌심부자극이 파킨슨병 환자들의 발성과 조음에 미치는 영향", 대한신경과학회지, 22(5), pp.472~477 (2004), 대한신경과학회
- B. Harel, "Acoustic characteristics of Parkinsonian speech: a potential biomarker of early disease progression and treatment", Journal of Neurolinguistics, 17, pp.439~453 (2004)
- K. Forest, "Kinematic, acoustic and perceptual analyses of connected speech produced by Parkinsonian and normal geriatric males", Journal of the Acoustical Society of America, 85, pp.2608~2622 (1989)
- A. Flint, "Acoustic analysis in the differentiation between Parkinson's Disease and major depression", Journal of Psycholinguistic Research, 21, pp.383~399 (1982)
- P. Kathe, "The Parkinson Larynx: Tremor and Videostroboscopic Findings", Journal of Voice, 10(4), pp.354~361 (1996)
- H. Braak, "Idiopathic Parkinson's disease: possible routes by the which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen", Journal of Neural Transmission, 110, pp.517~536 (2003)
- 성철재, "한국어 운율구조의 실험음성학적 연구: 지속시간과 관련하여", 국어학, 27, pp.179~201 (2004)