다형 홍반으로 발현한 신생아 루푸스와 역진단된 산모 루푸스 1례
A Case of Neonatal Lupus Erythematosus and Retrospectively Diagnosed with Asymtomatic Maternal Lupus Erythematosus
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
저자들은 다형 홍반과 구강 궤양으로 발현하였고 빈혈, 혈소판 감소증, 간기능 이상 등을 동반한 신생아 루푸스 환아의 확진과 신생아 진단을 통하여 무증상 산모 루푸스를 역으로 진단한1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.
Abstract
Neonatal lupus erythematosus (NLE) is a rare disease characterized by typical clinical features and the transplacental passage of maternal autoantibodies, particularly anti-SSA/Ro. The major clinical manifestations are cutaneous lupus lesions, congenital heart block, hematological disorders, and hepatobiliary diseases. We report a case of NLE presenting with multiple round and oval target-like erythematous skin lesions and abnormal liver function, born to a clinically asymptomatic mother whose diagnosis was made retrospectively only after her newborn’s diagnosis. Both the infant and the mother were positive for the anti-SSA/Ro and anti-SSB/La antibodies.
참고문헌 (20)
- McCuistion CH, "Possible discoid lupus erythematosus in newborn infant; report of a case with subsequent development of acute systemic lupus erythematosus in mother", AMA Arch Derm Syphilol, 70, pp.782~785 (1954)
- Laxer RM, "Liver disease in neonatal lupus erythematosus", J Pediatr, 116, pp.238~242 (1990)
- Rosh JR, "Intrahepatic cholestasis in neonatal lupus erythematosus", J Pediatr Gastroenterol Nutr, 17, pp.310~312 (1993)
- Lee LA, "Neonatal lupus liver disease", Lupus, 2, pp.333~338 (1993)
- Buyon JP, "Neonatal lupus", Curr Opin Rheumatol, 8, pp.485~490 (1996)
- Boh EE, "Neonatal lupus erythematosus", Clin Dermatol, 22, pp.125~128 (2004)
- Reichlin M, "Systemic lupus erythematosus. in Antibodies to ribonuclear proteins", Rheum Dis Clin North Am, 20, pp.29~43 (1994)
- Reed BR, "Autoantibodies to SS-A", Ro in infants with congenital heart block, 1983, pp.103, 889~891
- Lee LA, "Autoantibodies of neonatal lupus erythematosus", J Invest Dermatol, 102, pp.963~966 (1994)
- Tincani A, "Systemic lupus erythematosus in pregnancy", Lancet, 338, pp.756~757 (1991)
- Gimovsky ML, "Pregnancy outcome in women with systemic lupus erythematosus", Obstet Gynecol, 63, pp.686~692 (1984)
- Kleinman D, "Perinatal outcomes in women with systemic lupus erythematosus", J Perinatol, 18, pp.178~182 (1998)
- 신정현, "전신성 홍반성 루푸스와 임신의 상호 영향에 대한 연구", 대한내과학회지, 65(5), pp.511~519 (2003), 대한내과학회
- Kang HS, "The clinical characteristics and outcome of neonates born to systemic lupus erythematosus mothers", J Korean Soc Neonatol, 13, pp.139~148 (2006)
- Lee LA, "Neonatal lupus: clinical features and management", Paediatr Drugs, 6, pp.71~78 (2004)
- Park SH, "A case of neonatal lupus erythematosus with pancytopenia and bradycardia", J Korean Soc Neonatol, 8, pp.150~155 (2001)
- Tseng CE, "Neonatal lupus syndromes", Rheum Dis Clin North Am, 23, pp.31~54 (1997)
- Harris EN, "Anticardiolipin antibodies in autoimmune thrombocytopenic purpura", Br J Haematol, 59, pp.231~234 (1985)
- Burch JM, "Autoantibodies in mothers of children with neonatal liver disease", J Pediatr Gastroenterol Nutr, 37, pp.262~267 (2003)
- Geggel RL, "Postnatal progression from second- to third-degree heart block in neonatal lupus syndrome", J Pediatr, 113, pp.1049~1052 (1988)