Moderate Hemophilia B Diagnosed by Massive Gastrointestinal Hemorrhage on the First Day of Life: A Case Report and Literature Review
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Gastrointestinal hemorrhage in neonates is commonly associated with necrotizing enterocolitis, cow’s milk protein allergy, and gastrointestinal malformation. Gastrointestinal bleeding on the first day of life, presenting as the first manifestation of a disorder, has rarely been reported associations with gastric ulceration, Salmonella infection, and allergic colitis. Hemophilia B is also a rare cause of gastrointestinal bleeding during the neonatal period. In the present case, a male infant developed repetitive hematemesis on the first day of life. His initial level of coagulation factor IX was 1.9%, and he was diagnosed with moderate hemophilia B. No further hematemesis or melena was observed during recombinant factor IX therapy. The infant did not have a family history of hemophilia. In conclusion, although gastrointestinal hemorrhage on the first day of life as the first manifestation of a disease is rare, infants who present with spontaneous gastrointestinal hemorrhage after birth and with unexplained prolonged activated partial thromboplastin time should be evaluated for coagulation factor deficiency regardless of whether they have any family history of hemophilia.
Abstract
Gastrointestinal hemorrhage in neonates is commonly associated with necrotizing enterocolitis, cow’s milk protein allergy, and gastrointestinal malformation. Gastrointestinal bleeding on the first day of life, presenting as the first manifestation of a disorder, has rarely been reported associations with gastric ulceration, Salmonella infection, and allergic colitis. Hemophilia B is also a rare cause of gastrointestinal bleeding during the neonatal period. In the present case, a male infant developed repetitive hematemesis on the first day of life. His initial level of coagulation factor IX was 1.9%, and he was diagnosed with moderate hemophilia B. No further hematemesis or melena was observed during recombinant factor IX therapy. The infant did not have a family history of hemophilia. In conclusion, although gastrointestinal hemorrhage on the first day of life as the first manifestation of a disease is rare, infants who present with spontaneous gastrointestinal hemorrhage after birth and with unexplained prolonged activated partial thromboplastin time should be evaluated for coagulation factor deficiency regardless of whether they have any family history of hemophilia.
참고문헌 (15)
- Reish O, "Hemophilia B in a neonate: unusual early spontaneous gastrointestinal bleeding", Am J Perinatol, 11, pp.192~193 (1994)
- Piccin A, "Severe gastrointestinal haemorrhage, first manifestation of neonatal haemophilia A", Haemophilia, 15, pp.17~19 (2009)
- Pugh RJ, "Fatal bleeding from gastric ulceration during first day of life-possible association with social stress", Arch Dis Child, 54, pp.146~148 (1979)
- Chhabra RS, "Salmonella infection presenting as hematochezia on the first day", Pediatrics, 94, pp.739~741 (1994)
- Kumar D, "Allergic collitis presenting in the first day of life: report of three cases", J Pediatr Gastroenterol Nutr, 31, pp.195~197 (2000)
- Richards M, "Neonatal bleeding in haemophilia: a European cohort study", Br J Haematol, 156, pp.374~382 (2012)
- Kulkarni R, "Sites of initial bleeding episodes, mode of delivery and age of diagnosis in babies with haemophilia diagnosed before the age of 2 years: a report from The Centers for Disease Control and Prevention’s (CDC) Universal Data Collection (UDC) project", Haemophilia, 15, pp.1281~1290 (2009)
- Baehner RL, "Hemophilia in the first year of life", N Engl J Med, 275, pp.24~28 (1996)
- Kliegman RM, "Nelson textbook of pediatrics" (2016), Elsevier Co.
- Chalmers EA, "Neonatal coagulation problems", Arch Dis Child Fetal Neonatal Ed, 89, pp.F475~F478 (2004)
- Baujard C, "Diagnosis and anaesthesia management of haemophilia during the neonatal period", Paediatr Anaesth, 8 (1998)
- Stonebraker JS, "A study of variations in the reported haemophilia B prevalence around the world", Haemophilia, 18, pp.e91~e94 (2012)
- Conway JH, "Initial presentations of pediatric hemophiliacs", Arch Pediatr Adolesc Med, 148, pp.589~594 (1994)
- Barkat A, "Hemophilia in a newborn with an unusual clinical presentation", Arch Pediatr, 16, pp.1068~1070 (2009)
- Srivastava A, "Guidelines for the management of hemophilia", 19, pp.e1~e47 (2013)