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Environmental Mercury and Its Toxic Effects

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Mercury exists naturally and as a man-made contaminant. The release of processed mercury can lead to a progressive increase in the amount of atmospheric mercury, which enters the atmospheric-soil-water distribution cycles where it can remain in circulation for years. Mercury poisoning is the result of exposure to mercury or mercury compounds resulting in various toxic effects depend on its chemical form and route of exposure. The major route of human exposure to methylmercury (MeHg) is largely through eating contaminated fish, seafood, and wildlife which have been exposed to mercury through ingestion of contaminated lower organisms. MeHg toxicity is associated with nervous system damage in adults and impaired neurological development in infants and children. Ingested mercury may undergo bioaccumulation leading to progressive increases in body burdens. This review addresses the systemic pathophysiologyof individual organ systems associated with mercury poisoning. Mercury has profound cellular, cardiovascular, hematological, pulmonary, renal, immunological, neurological, endocrine, reproductive, and embryonic toxicological effects.

Abstract

Mercury exists naturally and as a man-made contaminant. The release of processed mercury can lead to a progressive increase in the amount of atmospheric mercury, which enters the atmospheric-soil-water distribution cycles where it can remain in circulation for years. Mercury poisoning is the result of exposure to mercury or mercury compounds resulting in various toxic effects depend on its chemical form and route of exposure. The major route of human exposure to methylmercury (MeHg) is largely through eating contaminated fish, seafood, and wildlife which have been exposed to mercury through ingestion of contaminated lower organisms. MeHg toxicity is associated with nervous system damage in adults and impaired neurological development in infants and children. Ingested mercury may undergo bioaccumulation leading to progressive increases in body burdens. This review addresses the systemic pathophysiologyof individual organ systems associated with mercury poisoning. Mercury has profound cellular, cardiovascular, hematological, pulmonary, renal, immunological, neurological, endocrine, reproductive, and embryonic toxicological effects.

참고문헌 (93)

  1. Clifton JC, "Mercury exposure and public health", Pediatr Clin North Am, 54(2), pp.237~269 (2007)
  2. Public Health Service. Toxicological profile for mercury, "US Department of Health and Human Services", US Department of Health and Human Services, 1~600 (1999)
  3. Mercury study report to Congress, "Rice GE", US Environmental Protection Agency, 1.1~6.30 (1997)
  4. Davidson PW, "Mercury exposure and child development outcomes", Pediatrics, 113(4 Suppl), pp.1023~1029 (2004)
  5. Goldman LR, "American Academy of Pediatrics: Committee on Environmental Health. Technical report: mercury in the environment: implications for pediatricians", Pediatrics, 108(1), pp.197~205 (2001)
  6. Harada M, "Monitoring of mercury pollution in Tanzania: relation between head hair mercury and health", Sci Total Environ, 227(2-3), pp.249~256 (1999)
  7. Guzzi G, "Molecular mechanisms triggered by mercury", Toxicology, 244(1), pp.1~12 (2008)
  8. Chang LW, "Neurotoxic effects of mercury: a review", Environ Res, 14(3), pp.329~373 (1977)
  9. Friberg L, "Accumulation of methylmercury and inorganic mercury in the brain", Biol Trace Elem Res, 21, pp.201~206 (1989)
  10. Magos L, "Overview of the clinical toxicity of mercury", Ann Clin Biochem, 43(Pt 4), pp.257~268 (2006)
  11. Clarkson TW, "Mercury: major issues in environmental health", Environ Health Perspect, 100, pp.31~38 (1993)
  12. Clarkson TW, "The toxicology of mercury and its chemical compounds", Crit Rev Toxicol, 36(8), pp.609~662 (2006)
  13. Mahaffey KR, "Methylmercury: a new look at the risks", Public Health Rep, 114(5), pp.396~399 (1999)
  14. Mozaffarian D, "Fish intake, contaminants, and human health: evaluating the risks and the benefits", JAMA, 296(15), pp.1885~1899 (2006)
  15. Sarafian T, "Oxidative mechanisms underlying methyl mercury neurotoxicity", Int J Dev Neurosci, 9(2), pp.147~153 (1991)
  16. "Toxicological profile for mercury"[URL]
  17. Joshi D, "Therapeutic potential of N-acetyl cysteine with antioxidants (Zn and Se) supplementation against dimethylmercury toxicity in male albino rats", Exp Toxicol Pathol, 64(1), pp.103~108 (2012)
  18. Schoeman K, "Hair methylmercury: a new indication for therapeutic monitoring", Ther Drug Monit, pp.289~293 (2010)
  19. Gundacker C, "The relevance of the individual genetic background for the toxicokinetics of two significant neurodevelopmental toxicants: mercury and lead", Mutat Res, 705(2), pp.130~140 (2010)
  20. Naganuma A, "Investigation of intracellular factors involved in methylmercury toxicity", Tohoku J Exp Med, 196(2), pp.65~70 (2002)
  21. Wang L, "Progress in developmental toxicity of methylmercury", Wei Sheng Yan Jiu, 34(5), pp.633~635 (2005)
  22. Flora SJ, "Heavy metal induced oxidative stress & its possible reversal by chelation therapy", Indian J Med Res, 128(4), pp.501~523 (2008)
  23. Lund BO, "Studies on Hg(II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria", Biochem Pharmacol, 45(10), pp.2017~2024 (1993)
  24. Peraza MA, "Effects of micronutrients on metal toxicity", Environ Health Perspect, 106(Suppl 1), pp.203~216 (1998)
  25. Haffner HT, "Morphological and toxicological findings after intravenous injection of metallic mercury", Dtsch Med Wochenschr, 116(36), pp.1342~1346 (1991)
  26. Frustaci A, "Marked elevation of myocardial trace elements in idiopathic dilated cardiomyopathy compared with secondary cardiac dysfunction", J Am Coll Cardiol, 33(6), pp.1578~1583 (1999)
  27. Drescher O, "Methylmercury exposure, PON1 gene variants and serum paraoxonase activity in Eastern James Bay Cree adults", J Expo Sci Environ Epidemiol (2014)
  28. Pyszel A, "Effect of metals, benzene, pesticides and ethylene oxide on the haematopoietic system", Med Pr, 56(3), pp.249~255 (2005)
  29. Kinjo Y, "Cancer mortality in Minamata disease patients exposed to methylmercury through fish diet", J Epidemiol, 6(3), pp.134~138 (1996)
  30. Robinson MM, "Dermatitis medicamentosa simulating Hodgexpokin’s disease due to mercury compounds", Ann Allergy, 10(1), pp.21~23 (1952)
  31. Flanders RA, "Mercury in dental amalgam: a public health concern?", J Public Health Dent, 52(5), pp.303~311 (1992)
  32. Liang YX, "Psychological effects of low exposure to mercury vapor: application of a computer-administered neurobehavioral evaluation system", Environ Res, 60(2), pp.320~327 (1993)
  33. Heyer NJ, "Chronic low-level mercury exposure, BDNF polymorphism, and associations with self-reported symptoms and mood", Toxicol Sci, 81(2), pp.354~363 (2004)
  34. Hendry WF, "Was Young’s syndrome caused by exposure to mercury in childhood?", BMJ, 307(6919), pp.1579~1582 (1993)
  35. Tchounwou PB, "Environmental exposure to mercury and its toxicopathologic implications for public health", Environ Toxicol, 18(3), pp.149~175 (2003)
  36. Haddad JK, "Bronchitis due to acute mercury inhalation. Report of two cases", Am Rev Respir Dis, 88, pp.543~545 (1963)
  37. Vojdani A, "Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism", Int J Immunopathol Pharmacol, 16(3), pp.189~199 (2003)
  38. Summers AO, "Mercury released from dental “silver” fillings provokes an increase in mercury- and antibiotic-resistant bacteria in oral and intestinal floras of primates", Antimicrob Agents Chemother, 37(4), pp.825~834 (1993)
  39. Li SJ, "Mercury-induced membranous nephropathy: clinical and pathological features", Clin J Am Soc Nephrol, 5(3), pp.439~444 (2010)
  40. 박정덕, "Human Exposure and Health Effects of Inorganic and Elemental Mercury", 예방의학회지, 45(6), pp.344~352 (2012), 대한예방의학회
  41. Oliveira DB, "Membranous nephropathy caused by mercury-containing skin lightening cream", Postgrad Med J, 63(738), pp.303~304 (1987)
  42. Miller S, "Mercury-associated nephrotic syndrome: a case report and systematic review of the literature", Am J Kidney Dis, 62(1), pp.135~138 (2013)
  43. Wada H, "Suppressed adrenocortical responses and thyroid hormone levels in birds near a mercury-contaminated river", Environ Sci Technol, 43(15), pp.6031~6038 (2009)
  44. Shenker BJ, "Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. I. Suppression of T-cell activation", Immunopharmacol Immunotoxicol, 14(3), pp.539~553 (1992)
  45. Gardner RM, "Differential immunotoxic effects of inorganic and organic mercury species in vitro", Toxicol Lett, 198(2), pp.182~190 (2010)
  46. Warren HV, "Geology, trace elements and health", Soc Sci Med, 29(8), pp.923~926 (1989)
  47. Singh VK, "Phenotypic expression of autoimmune autistic disorder (AAD): a major subset of autism", Ann Clin Psychiatry, 21(3), pp.148~161 (2009)
  48. Schofield P., "Dementia associated with toxic causes and autoimmune disease", Int Psychogeriatr, 17(Suppl 1), pp.S129~S147 (2005)
  49. Johnson FO, "The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosis", Neurotoxicology, 30(5), pp.761~765 (2009)
  50. Hybenova M, "The role of environmental factors in autoimmune thyroiditis", Neuro Endocrinol Lett, 31(3), pp.283~289 (2010)
  51. Landrigan PJ, "What causes autism? Exploring the environmental contribution", Curr Opin Pediatr, 22(2), pp.219~225 (2010)
  52. Ceccatelli S, "Methylmercury-induced neurotoxicity and apoptosis", Chem Biol Interact, 188(2), pp.301~308 (2010)
  53. Kazantzis G, "Mercury exposure and early effects: an overview", Med Lav, 93(3), pp.139~147 (2002)
  54. Wu MF, "Cutaneous and auditory function in rats following methyl mercury poisoning", Toxicol Appl Pharmacol, 79(3), pp.377~388 (1985)
  55. Solt I, "Childhood vaccines and autism: much ado about nothing?", Harefuah, 149(4), pp.251~255 (2010)
  56. Bhardwaj A, "Electrical characteristics of PbSe nanoparticle", Si heterojunctions, 2009, pp.9(10), 5953~5957
  57. Minoia C, "Effects of mercury on the endocrine system", Crit Rev Toxicol, 39(6), pp.538~ (2009)
  58. Iavicoli I, "The effects of metals as endocrine disruptors", J Toxicol Environ Health B Crit Rev, 12(3), pp.206~223 (2009)
  59. Tan SW, "The endocrine effects of mercury in humans and wildlife", Crit Rev Toxicol, 39(3), pp.228~269 (2009)
  60. Nylander M, "Mercury and selenium concentrations and their interrelations in organs from dental staff and the general population", Br J Ind Med, 48(11), pp.729~734 (1991)
  61. McGregor AJ, "Occupational mercury vapour exposure and testicular, pituitary and thyroid endocrine function", Hum Exp Toxicol, 10(3), pp.199~203 (1991)
  62. Chen YW, "Methylmercury induces pancreatic beta-cell apoptosis and dysfunction", Chem Res Toxicol, 19(8), pp.1080~1085 (2006)
  63. Davis BJ, "O’Connor RW, Fernando R, Rowland AS, Morgan DL. Mercury vapor and female reproductive toxicity", Toxicol Sci, 59(2), pp.291~296 (2001)
  64. Schrag SD, "Occupational exposures associated with male reproductive dysfunction", Annu Rev Pharmacol Toxicol, 25, pp.567~592 (1985)
  65. Rowland AS, "The effect of occupational exposure to mercury vapour on the fertility of female dental assistants", Occup Environ Med, 51(1), pp.28~34 (1994)
  66. Colquitt PJ, "The effect of occupational exposure to mercury vapour on the fertility of female dental assistants", Occup Environ Med, 52(3), pp.214~ (1995)
  67. Dickman MD, "Hong Kong male subfertility links to mercury in human hair and fish", Sci Total Environ, 214, pp.165~174 (1998)
  68. Boujbiha MA, "Testicular toxicity in mercuric chloride treated rats: association with oxidative stress", Reprod Toxicol, 28(1), pp.81~89 (2009)
  69. Yoshida M, "Placental to fetal transfer of mercury and fetotoxicity", Tohoku J Exp Med, 196(2), pp.79~88 (2002)
  70. Castoldi AF, "Neurotoxicity and molecular effects of methylmercury", Brain Res Bull, 55(2), pp.197~203 (2001)
  71. Myers GJ, "Prenatal methylmercury exposure and children: neurologic, developmental, and behavioral research", Environ Health Perspect, 106(Suppl 3), pp.841~847 (1998)
  72. Burbacher TM, "Methylmercury exposure and reproductive dysfunction in the nonhuman primate", Toxicol Appl Pharmacol, 75(1), pp.18~24 (1984)
  73. Choi BH, "Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero", J Neuropathol Exp Neurol, 37(6), pp.719~733 (1978)
  74. Grandjean P, "Methylmercury: significance of intrauterine and postnatal exposures", Clin Chem, 40(7 Pt 2), pp.1395~1400 (1994)
  75. Bakir F, "Methylmercury poisoning in Iraq", Science, 181(4096) (1973)
  76. Mottet NK, "Health risks from increases in methylmercury exposure", Environ Health Perspect, 63, pp.133~140 (1985)
  77. Meacham CA, "Accumulation of methylmercury or polychlorinated biphenyls in in vitro models of rat neuronal tissue", Toxicol Appl Pharmacol, 205(2), pp.177~187 (2005)
  78. Zhao HL, "The short-lived Chinese emperors", J Am Geriatr Soc, 54(8), pp.1295~1296 (2006)
  79. Waldron HA, "Did the Mad Hatter have mercury poisoning?", Br Med J (Clin Res Ed), 287(6409), pp.1961~ (1983)
  80. Doherty MJ, "The quicksilver prize: mercury vapor poisoning aboard HMS Triumph and HMS Phipps", Neurology, 62(6), pp.963~966 (2004)
  81. Burnett W, "An account of the effect of mercurial vapours on the crew of his majesty’s ship triumph, in the year 1810", Philos Trans R Soc Lond, 113, pp.402~408 (1823)
  82. Westbrook JH, "Metallurgical and chemical applications of intermetallics", MRS Bull, 21(5), pp.37~43 (1996)
  83. Broussard LA, "The toxicology of mercury", Lab Med, 33(8), pp.614~625 (2002)
  84. Hyman HT, "Massive dose arsenotherapy of syphilis by the intravenous drip method: five-year observations", Am J Med Sci, 197(4), pp.480~484 (1939)
  85. Hunter D, "Poisoning by methylmercury compounds", Q J Med, 9(3), pp.193~226 (1940)
  86. Engler R, "Technology out of control", Nation, 240(16), pp.488~ (1985)
  87. Witt SF, "OSHA safety hazard information bulletin on dimethylmercury", US Department of Labor, Occupational Safety and Health Administration, 1~ (1991)
  88. "Colbert man dies from mercury poisoning; 2008 Apr 1"[URL]
  89. Hamann CR, "Spectrometric analysis of mercury content in 549 skin-lightening products: is mercury toxicity a hidden global health hazard?", J Am Acad Dermatol, 70(2), pp.281~287 (2014)
  90. Adawe A, "Skin-lightening practices and mercury exposure in the Somali community", Minn Med, 96(7), pp.48~49 (2013)
  91. Singer MB, "Enduring legacy of a toxic fan via episodic redistribution of California gold mining debris", Proc Natl Acad Sci U S A, 110(46), pp.18436~18441 (2013)
  92. Nunes E, "Children’s health risk and benefits of fish consumption: risk indices based on a diet diary follow-up of two weeks", J Toxicol Environ Health A, 77(1-3), pp.103~114 (2014)
  93. Rodriguez Martin-Doimeadios RC, "Comparative study of mercury speciation in commercial fishes of the Brazilian Amazon", Environ Sci Pollut Res Int (2014)

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