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Effect of Gamma-Aminobutyric Acid on the Gustatory Nucleus Tractus Solitarius in Rats

정지연|박상원|김원재|방몽숙|정연진|박하옥|김선헌|김미원
대한구강생물학회 (Korean Academy Of Oral Biology)|2005.09|International Journal of Oral Biology|제30권 제3호|pp. 91-98

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참고문헌

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초록

Abstract

Gamma-aminobutyric acid (GABA) is known as an inhibitory neurotransmitter in the neurons of the central nervous system. However, its detailed action mechanisms in the rostral gustatory zone of the nucleus tractus solitarius (rNTS) have not been established. The present study was aimed to investigate the distribution, role and action mechanisms of GABA in rNTS. Membrane potentials were recorded by whole cell recordings in isolated brain slices of the rat medulla. Superfusion of GABA resulted in a concentration-dependent reduction in input resistance in the neurons in rNTS. The change in input resistance ws accompanied by response to a depolarizing pulse were diminished by GABA. Superfusion of the slices with either GABAA agonist, muscimol, GABAB agonist, baclofen or GABAc agonist, TACA, decreased input resistance and reduced the nerve activity in association with membrane hyperpolarization. It is suggested that inhibitory signals play a role in sensory processing by the rNTS, in that GABA actions occur through activation of GABAA, GABAB and GABAc receptor. These results suggest that GABA has an inhibitory effect on the rNTS through an activation of GABAA, GABAB and GABAc receptors and that the GABAergic inhibition probably plays an important role in sensory processing by the rNTS.

참고문헌 (36)

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