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Methylation Status and Expression of E-cadherin in Oral Squamous Cell Carcinomas Compared to Benign Oral Epithelial Lesions

이동근|조의식|이석근|민명기|손현진|추정엽|조남표
대한구강생물학회 (Korean Academy Of Oral Biology)|2006.06|International Journal of Oral Biology|제31권 제2호|pp. 27-32

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초록

Abstract

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline mutations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast cancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methy-lation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma (SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign epithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

참고문헌 (26)

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관련 논문AI추천

구강 편평세포암에서 E-cadherin 유전자의 과메틸화이원, 김영실, 김창현, 박민규, 박지영, 표성운대한구강악안면외과학회 · 대한구강악안면외과학회지2008 · 제34권 제2호구강 편평세포암종에서 E-cadherin의 발현과 임상병리학적 지표와의 관계김영실, 김창현, 신재명, 표성운대한구강악안면외과학회 · 대한구강악안면외과학회지2005 · 제31권 제1호구강 편평상피암종에서 CDH-13 유전자의 promoter methylation에 대한 연구김경욱, 이문주, 한세진대한구강악안면외과학회 · 대한구강악안면외과학회지2008 · 제34권 제5호구강설 편평세포암종에서 E-Cadherin과 Matrix Metalloproteinase-2의 발현김민식, 선동일, 이근석, 이수진, 조승호대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2003 · 제46권 제8호Methylation of p16 and E-cadherin in ameloblastoma박상준, 박찬웅, 윤혜경대한구강악안면외과학회 · 대한구강악안면외과학회지2010 · 제36권 제6호The Role of E-cadherin/β-catenin Complex and Cyclin D1 in Head and Neck Squamous Cell Carcinoma도남용, 임성철, Sung Yong Park대한암학회 · Cancer Research and Treatment2004 · 제36권 제1호

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