Efficacy of Trichloroacetic Acid in Patients with Toenail Onychomycosis: Pilot Study with 14 Patients
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Background: Various methods have been employed for treatment of onychomycosis. These methodscan be categorized as topical, oral, or device-related. Among them, oral therapies have been regarded asthe gold standard for treatment. However, the efficacy of oral therapies on onychomycosis remains limitedand safety may be an issue, leaving many patients in need of alternative treatments. As an alternativetreatment for onychomycosis, topical therapies are under investigation with great interest. Objective: We conducted an investigation on the efficacy of trichloroacetic acid (TCA) as a newtherapeutic option in treatment of onychomycosis. Methods: Fourteen patients with onychomycosis in both great toenails, which was confirmed byfungal examination, were enrolled. About 0.1 ml of 100% TCA solution was applied on one great toenailof the patients eight times at an interval of one week. The other great toenail of the patients was treatedwith vehicle. Results: At the end of the treatment period, clinical improvement of TCA-treated great toenails withonychomycosis was observed in eleven out of 14 patients. By contrast, no clinical improvement wasobserved in vehicle-treated great toenails with onychomycosis. Irritant contact dermatitis of the periungualnail folds occurred in 29% as an adverse effect. Conclusions: Topical solution of TCA may become a new therapeutic option for treatment of patientswith onychomycosis who desire alternatives to oral antifungal agents.
Abstract
Background: Various methods have been employed for treatment of onychomycosis. These methodscan be categorized as topical, oral, or device-related. Among them, oral therapies have been regarded asthe gold standard for treatment. However, the efficacy of oral therapies on onychomycosis remains limitedand safety may be an issue, leaving many patients in need of alternative treatments. As an alternativetreatment for onychomycosis, topical therapies are under investigation with great interest. Objective: We conducted an investigation on the efficacy of trichloroacetic acid (TCA) as a newtherapeutic option in treatment of onychomycosis. Methods: Fourteen patients with onychomycosis in both great toenails, which was confirmed byfungal examination, were enrolled. About 0.1 ml of 100% TCA solution was applied on one great toenailof the patients eight times at an interval of one week. The other great toenail of the patients was treatedwith vehicle. Results: At the end of the treatment period, clinical improvement of TCA-treated great toenails withonychomycosis was observed in eleven out of 14 patients. By contrast, no clinical improvement wasobserved in vehicle-treated great toenails with onychomycosis. Irritant contact dermatitis of the periungualnail folds occurred in 29% as an adverse effect. Conclusions: Topical solution of TCA may become a new therapeutic option for treatment of patientswith onychomycosis who desire alternatives to oral antifungal agents.
참고문헌 (14)
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