Purpureocillium lilacinum 에 의한 국소피부감염증 1예
A Case of Localized Skin Infection due to Purpureocillium lilacinum
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초록
Purpureocillium lilacinum, formerly Paecilomyces lilacinus, is a saprophytic fungus found in soil and rotting vegetation and rarely pathogenic to humans. Only 4 cases of cutaneous infection caused by Purpureocillium lilacinum have been reported in the name of Paecilomyces lilacinus. Herein, we report a case of localized cutaneous infection due to Purpureocillium lilacinum. A healthy 81-year-old immunocompetent male presented with an erythematous scaly and pustular plaque on his left dorsal hand that had begun 3 months ago. Histopathologic examination showed suppurative granulomatous inflammation with hyphae and round spores in the dermis. Periodic acid-Schiff and methenamine silver stain revealed fungal spores. Fungus culture from the biopsy specimen revealed velvety pink to white colonies after 15 day-incubation period. The slide culture stained with lactophenol-cotton blue showed typical long hyphae and flask-shaped phialides with oval conidia in chains. The result of DNA sequencing from the colony was identical to that of Purpureocillium lilacinum.
Abstract
Purpureocillium lilacinum, formerly Paecilomyces lilacinus, is a saprophytic fungus found in soil and rotting vegetation and rarely pathogenic to humans. Only 4 cases of cutaneous infection caused by Purpureocillium lilacinum have been reported in the name of Paecilomyces lilacinus. Herein, we report a case of localized cutaneous infection due to Purpureocillium lilacinum. A healthy 81-year-old immunocompetent male presented with an erythematous scaly and pustular plaque on his left dorsal hand that had begun 3 months ago. Histopathologic examination showed suppurative granulomatous inflammation with hyphae and round spores in the dermis. Periodic acid-Schiff and methenamine silver stain revealed fungal spores. Fungus culture from the biopsy specimen revealed velvety pink to white colonies after 15 day-incubation period. The slide culture stained with lactophenol-cotton blue showed typical long hyphae and flask-shaped phialides with oval conidia in chains. The result of DNA sequencing from the colony was identical to that of Purpureocillium lilacinum.
참고문헌 (20)
- Clark NM, "Paecilomyces lilacinus infection in a heart transplant recipient and successful treatment with terbinafine", Clin Infect Dis, 28, pp.1169~1170 (1999)
- Luangsa-Ard J, "Purpureocillium, a new genus for the medically important Paecilomyces lilacinus", FEMS Microbiol Lett, 321, pp.141~149 (2011)
- Cho GY, "Facial cutaneous mycosis by Paecilomyces lilacinus", Korean J Dermatol, 22, pp.89~93 (1984)
- Shin SB, "Cutaneous abscess caused by Paecilomyces lilacinus in a renal transplant patient", Korean J Med Mycol, 3, pp.185~189 (1998)
- 고우태, "Paecilomyces lilacinus에 의한 국소 피부감염증 1예", 대한피부과학회지, 45(9), pp.930~933 (2007), 대한피부과학회
- 정미영, "Voriconazole로 치료한 Paecilomyces lilacinus 국소 피부 감염증", 대한피부과학회지, 51(10), pp.833~836 (2013), 대한피부과학회
- Van Schooneveld T, "Paecilomyces lilacinus infection in a liver transplant patient: Case report and review of the literature", Transpl Infect Dis, 10, pp.117~122 (2008)
- Sung GH, "Phylogenetic classification of Cordyceps and the clavicipitaceous fungi", Stud Mycol, 57, pp.5~59 (2007)
- Perdomo H, "Polyphasic analysis of Purpureocillium lilacinum isolates from different origins and proposal of the new species Purpureocillium lavendulum", Mycologia, 105, pp.151~161 (2013)
- Fenech FF, "Pleural effusion caused by Penicillium lilacinus", Br J Dis Chest, 66, pp.284~290 (1972)
- Pastor FJ, "Clinical manifestations, treatment and outcome of Paecilomyces lilacinus infection", Clin Microbiol Infect, 12, pp.948~960 (2006)
- Takayasu S, "Cutaneous mycosis caused by Paecilomyces lilacinus", Arch Dermatol, 113, pp.1687~1690 (1977)
- Gutierrez-Rodero F, "Cutaneous hyalohyphomycosis caused by Paecilomyces lilacinus in an immunocompetent host successfully treated with itraconazole:Case report and review", Eur J Clin Microbiol Infect Dis, 18, pp.814~818 (1999)
- 원재연, "전층각막이식 환자에서 발병한 Paecilomyces lilacinus 진균 각막염 1예", 대한안과학회지, 55(9), pp.1384~1387 (2014), 대한안과학회
- 정새롬, "패실로마이세스 각막염: 국내 증례 보고 및 해외 문헌 고찰", 대한안과학회지, 57(3), pp.390~398 (2016), 대한안과학회
- 김재력, "Purpureocillium lilacinum 에 의한 진균 각막염 1예: 국내 증례의 미생물학적 고찰", 대한의진균학회지, 21(3), pp.84~91 (2016), 대한의진균학회[DOI]
- Castro LG, "Hyalohyphomycosis by Paecilomyces lilacinus in a renal transplant patient and a review of human Paecilomyces species infections", J Med Vet Mycol, 28, pp.15~26 (1990)
- Keshtkar-Jahromi M, "Unusual case of cutaneous and synovial Paecilomyces lilacinus infection of hand successfully treated with voriconazole and review of published literature", Mycopathologia, 174, pp.255~258 (2012)
- Huang CY, "Cutaneous hyalohyphomycosis caused by Paecilomyces lilacinus successfully treated by oral voriconazole and nystatin packing", Mycopathologia, 172, pp.141~145 (2011)
- Ortoneda M, "In vitro interactions of approved and novel drugs against Paecilomyces spp", Antimicrob Agents Chemother, 48, pp.2727~2729 (2004)