A Case of Deep Cutaneous Mycosis Caused by Purpureocillium lilacinum
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Purpureocillium lilacinum, previously known as Paecilomyces lilacinus, is a saprophytic fungus typically found in soil and decaying vegetation. Although it is infrequently pathogenic to humans, recent reports of P. lilacinum infections, primarily affecting the skin and eyes, have shown an increase. This report details a cutaneous infection caused by P. lilacinum in an 89-year-old woman. She presented with a 3-month history of an erythematous patch and nodule on her right forearm. A skin biopsy revealed inflammation, granuloma, and fungal organisms in the dermis. Periodic acid-Schiff (PAS) staining confirmed the presence of fungal elements. The fungal culture of the medium produced colonies with a velvety pink and brown hue. PCR testing on these cultured samples identified P. lilacinum. The patient received a 2-week course of oral itraconazole (200 mg/day), which improved her symptoms. However, ongoing antifungal treatment was necessary. Additionally, due to a recent myocardiac infarction, the patient required a statin. A MIC test was conducted to identify an antifungal drug compatible with statin therapy.
Abstract
Purpureocillium lilacinum, previously known as Paecilomyces lilacinus, is a saprophytic fungus typically found in soil and decaying vegetation. Although it is infrequently pathogenic to humans, recent reports of P. lilacinum infections, primarily affecting the skin and eyes, have shown an increase. This report details a cutaneous infection caused by P. lilacinum in an 89-year-old woman. She presented with a 3-month history of an erythematous patch and nodule on her right forearm. A skin biopsy revealed inflammation, granuloma, and fungal organisms in the dermis. Periodic acid-Schiff (PAS) staining confirmed the presence of fungal elements. The fungal culture of the medium produced colonies with a velvety pink and brown hue. PCR testing on these cultured samples identified P. lilacinum. The patient received a 2-week course of oral itraconazole (200 mg/day), which improved her symptoms. However, ongoing antifungal treatment was necessary. Additionally, due to a recent myocardiac infarction, the patient required a statin. A MIC test was conducted to identify an antifungal drug compatible with statin therapy.
참고문헌 (14)
- Lu KL, "Cutaneous infection caused by Purpureocillium lilacinum : Case reports and literature review of infections by Purpureocillium and Paecilomyces in Taiwan", J Dermatol, 50, pp.1088~1092 (2023)
- Kim HJ, "A case of deep cutaneous Purpureocillium lilacinum fungal infection in an immunocompetent patient", J Mycol Infect, 24, pp.52~57 (2019)
- Jung ES, "A case of cutaneous Purpureocillium lilacinum infection", J Mycol Infect, 26, pp.8~12 (2021)
- Corrêa-Moreira D, "Purpureocillium lilacinum an emergent pathogen : antifungal susceptibility of environmental and clinical strains", Lett Appl Microbiol, 75, pp.45~50 (2022)
- Cho GY, "Facial cutaneous mycosis by Paecilomyces lilacinus", Korean J Dermatol, 22, pp.89~93 (1984)
- Shin SB, "Cutaneous abscess caused by Paecilomyces lilacinus in a renal transplant patient", Korean J Dermatol, 3, pp.185~189 (1998)
- Ko WT, "A case of localized skin infection due to Paecilomyces lilacinus", Koran J Dermatol, 45, pp.930~933 (2007)
- Hwang SL, "A localized skin infection due to Paecilomyces lilacinus", Korean J Dermatol, 64, pp.255~ (2011)
- Jung MY, "A localized cutaneous Paecilomyces lilacinus infection treated with voriconazole", Korean J Dermatol, 51, pp.833~836 (2013)
- Kwak HB, "A case of localized skin infection due to Paecilomyces lilacinum", J Mycol Infect, 22, pp.42~49 (2017)
- Ha NG, "A case of cutaneous Purpureocillium lilacinum infection looking like psoriasis", J Mycol Infect, 26, pp.72~76 (2021)
- Kim JH, "Therapeutic use of posaconazole for cutaneous Purpureocillium lilacinum infection refractory to itraconazole", J Mycol Infect, 28, pp.79~83 (2023)
- Wang Y, "Case report : cutaneous mycosis caused by Purpureocillium lilacinum", Am J Trop Med Hyg, 108, pp.693~695 (2023)
- Burgos-Blasco B, "Purpureocillium lilacinum fungal keratitis : Confocal microscopy diagnosis and histopathology correlation", Med Clin(Barc), 157, pp.398~399 (2021)