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Effects of Interleukin-1b, Tumor Necrosis Factor-a and Interferon-g on the Nitric Oxide Production and Osteoclast Generation in the Culture of Mouse Bone Marrow Cells

김세원|고선일|권영만
대한구강생물학회 (Korean Academy Of Oral Biology)|2006.06|International Journal of Oral Biology|제31권 제2호|pp. 67-72

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주제분류치의학

초록

Abstract

Nitric oxide (NO) is a labile, uncharged, reactive radical that functions as a sensitive mediator of intercellular communication in diverse tissues. It has been reported that NO is produced by osteoblast and these results may suggest that NO is integrally involved in the regulation of osteoclast formation and osteoclast resorption activity by osteoblastic cells. We examined the effect of cytokines on NO release by mouse bone marrow cell. We also examined the effects of cytokines and sodium nitroprusside (SNP) on the formation of osteoclast-like cell from mouse bone marrow cells in culture. Cytokines stimulated NO production of mouse bone marrow cells, and N-nitro-L-arginine methyl ester, a specific inhibitor of NO synthase, suppressed the cytokine-induced NO production. SNP showed dual action in the generation of osteoclasts. The addition of 30 M SNP inhibited the formation of tartrate resistant acid phosphatase (TRAP)(+) multinucleated cell, whereas lower concentration (3 M) of SNP enhanced it. Although the precise action of NO remains to be elucidated in detail, the action of NO in osteoclast generation in our studies seems to be associated, at least in part, with bone metabolism and bone patho-physiology.

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