Sexual Life Cycle of Aspergillus fumigatus
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Aspergillus fumigatus, the major etiologic agent of invasive aspergillosis, is a bipolar heterothallic species that produces teleomorphs belonging to the genus Neosartorya. Unlike A. fischeri and other sexual species phylogenetically related to A. fumigatus, the discovery of a sexual state in A. fumigatus was unduly delayed due to its requirement of extraordinarily fastidious environmental conditions for the completion of the sexual life cycle compounded with low fertility of the species. A wide range in the degree of fertility and duration required for completion of the sexual life cycle appear to exist among clinical as well as environmental isolates. Discovery and characterization of a pair of opposite mating type strains with high fertility that could produce viable ascospores is urgently needed as a tool of recombinational analysis.
Abstract
Aspergillus fumigatus, the major etiologic agent of invasive aspergillosis, is a bipolar heterothallic species that produces teleomorphs belonging to the genus Neosartorya. Unlike A. fischeri and other sexual species phylogenetically related to A. fumigatus, the discovery of a sexual state in A. fumigatus was unduly delayed due to its requirement of extraordinarily fastidious environmental conditions for the completion of the sexual life cycle compounded with low fertility of the species. A wide range in the degree of fertility and duration required for completion of the sexual life cycle appear to exist among clinical as well as environmental isolates. Discovery and characterization of a pair of opposite mating type strains with high fertility that could produce viable ascospores is urgently needed as a tool of recombinational analysis.
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